The expressome, featured as the Molecule of the Month in January 2021, is a structure that tells an entire story. The complex shows the “Central Dogma” of molecular biology, with a small piece of DNA being unwound and transcribed into mRNA by RNA polymerase and an associated ribosome aligning tRNA and translating the mRNA into protein. Two small transcription factors, NusA and NusG, hold the whole assembly in place. Reproduced with permission from D. S. Goodsell, “Epressome,” in PDB-101 (2021). Copyright 2021 Author, licensed under a Creative Commons CC-BY-4.0 license.