The astrocytoma tumor-exclusive genotype encodes for increased cell communication via the canonical Notch pathway in support of transformation via the Ras, Shh, and hominin-specific Notch pathways. The astrocytoma genotype is depicted in a diagram of the WGS technology-filled in Notch pathway (yellow) in addition to the microarray-described Ras and Shh pathways, which include CNAs unrecognized in GBM prior to the discovery of the GBM pattern (violet). Explicitly shown are amplifications (red) and deletions (green) of genes and transcript variants (rectangles), either GBM- and LGA-shared (black) or GBM-specific (blue), and relationships that directly or indirectly lead to increased (arrows) or decreased (bars) activities of the genes and transcripts, the tumor suppressor proteins p53, Rb, and Ptch1, and the oncoproteins Notch1, Notch2, and Notch2nl (circles).