The past two decades have seen explosive growth in research on structural molecular biology. High-throughput techniques for determining biological structures are yielding large amounts of information about atomic-, cellular-, and tissue-scale organization. Advances are driven by modern high-brilliance synchrotron sources, synchrotron-based full-field x-ray microscopy and tomography, free-electron lasers, and cryoelectron microscopy facilities. The scientific landscape is changing at a remarkable pace with increasing emphasis being placed on interdisciplinary and multi-technique approaches. Neutron scattering facilities around the globe are expanding their capabilities to provide unique and complementary insights about biological systems.1
Neutron-based techniques have become increasingly powerful and sophisticated tools for structural biology research. Recent improvements in sources, instrumentation, and sample preparation have revolutionized the scope of biological neutron scattering. Although such methods have been used to probe macromolecules2 since the 1960s, their application to the study of biological systems was limited because data acquisition was technically difficult and...