Nanowires transport biomolecular cargo

Biological and medical researchers have long sought to study or control cellular function by inserting biomolecular probes inside the cell. But those probes, which include peptides and nucleic acids, must first cross the cell’s highly selective membrane. Traditional approaches to breaching that barrier are to chemically modify the probe or membrane and to pack the probe into a virus, which fuses to a cell’s membrane before depositing its load; both methods induce unwanted side effects and are limited to delivering specific molecular cargo. Now a team of US and South Korean scientists, led by Harvard University’s Hongkun Park, has developed a minimally invasive delivery method that exploits the ability of silicon nanowires to physically penetrate the cell’s membrane. The researchers prepared vertically aligned nanowire arrays with a density of roughly 25 million nanowires/cm² and altered their surface chemistries to enable noncovalent binding of a broad spectrum of molecules. With...