Photonic-crystal slab for biodetection

The public-health and biosecurity communities need biosensors that are sensitive, operate in real time, and can be easily deployed. Many approaches are being pursued, including one by a group from Lawrence Livermore National Laboratory that uses a photonic crystal (PC) slab connected to two waveguides. The idea is for viruses or other tiny pathogens to randomly infiltrate the pores of a silicon PC, whose optical properties—specifically, the in-plane transmission spectrum’s band edge—change accordingly. First, the researchers used simulations to determine a PC geometry suitable for a specific virus, vaccinia, and for their laser’s wavelength. They then fabricated an appropriate 17 × 17 array of 280-nm pores and exposed it to a flux of polystyrene beads with two different sizes; those with 260-nm diameter entered the pores (see the figure, with empty and filled pores enlarged) while 320-nm ones did not. The measured band-edge redshifts were then used to calibrate...