For many years, the Optical Radiation Branch of the Air Force Research Laboratory has conducted research to develop a greater understanding of the transient effects of visible laser exposures on human vision. Although laser warning signs instruct people to avoid eye exposure and to not stare into the beam, for our studies we often require human subjects to disregard this advice. With carefully planned and controlled laser exposure conditions, the eye can safely view laser light without any expectation of injury. In order to comply with the federal policy for the protection of human subjects, and conduct this research safely, there are many factors that need to be considered. While generic human research issues such as informed consent and risk-benefit analysis are not unique to laser research, other aspects such as the laser safety calculations and eye examination requirements are more specific. This paper will discuss these matters in the context of exposing human subjects to lasers for non-therapeutic research.
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