Low-power laser therapy (LLLT) has become a common practice in medicine, particularly in physical medicine and rehabilitation. The purpose of this review study was to evaluate the effect of low-level laser therapy on neurological disorders such as peripheral nerve regeneration, spinal cord injury, stroke, and neurodegenerative diseases. Laser therapy increases ATP synthesis and reduces oxidative stress by improving the efficiency of the electron transport chain in the mitochondria. It also activates transcription factors, suppresses inflammatory factors, and influences neurotrophic factors such as brain-derived neurotrophic factor and nerve growth factor. This review study affirms the beneficial effect of LLLT on neurorehabilitation since LLLT produced a significant amount of structural and cellular change. The results of this review suggest that laser therapy may be a viable approaches for treatment the neurological disorders.

1.
M. B.
Alahri
,
R.
Arshadizadeh
,
M.
Raeisi
,
M.
Khatami
,
M. S.
Sajadi
,
W. K.
Abdelbasset
,
R.
Akhmadeev
, and,
S.
Iravani
, “
Theranostic applications of metal-organic frameworks (MOFs)-based materials in brain disorders: Recent advances and challenges
,”
Inorg. Chem. Commun.
134
,
108997
(
2021
).
2.
V. L.
Feigin
,
T.
Vos
,
E.
Nichols
 et al., “
The global burden of neurological disorders: Translating evidence into policy
,”
Lancet Neurol.
19
,
255
265
(
2020
).
3.
A. R.
Filous
and
J. M.
Schwab
, “
Determinants of axon growth, plasticity, and regeneration in the context of spinal cord injury
,”
Am. J. Pathol.
188
,
53
62
(
2018
).
4.
G.
Mohammad-Bagher
,
A.
Arash
,
B.-R.
Morteza
,
M.-S.
Naser
, and
M.
Ali
, “
Synergistic effects of acetyl-l-carnitine and adipose-derived stromal cells on improving regenerative capacity of acellular nerve allograft in sciatic nerve defect
,”
J. Pharmacol. Exp. Ther.
368
,
490
502
(
2019
).
5.
R.
Polania
,
M. A.
Nitsche
, and
C. C.
Ruff
, “
Studying and modifying brain function with non-invasive brain stimulation
,”
Nat. Neurosci.
21
,
174
187
(
2018
).
6.
A.
Guerra
,
V.
López-Alonso
,
B.
Cheeran
, and
A.
Suppa
, “
Variability in non-invasive brain stimulation studies: Reasons and results
,”
Neurosci. Lett.
719
,
133330
(
2020
).
7.
R.
Cassani
,
G. S.
Novak
,
T. H.
Falk
, and
A. A.
Oliveira
, “
Virtual reality and non-invasive brain stimulation for rehabilitation applications: A systematic review
,”
J. Neuroeng. Rehabilitation
17
,
1
16
(
2020
).
8.
R. A.
Mussttaf
,
D. F.
Jenkins
, and
A. N.
Jha
, “
Assessing the impact of low level laser therapy (LLLT) on biological systems: A review
,”
Int. J. Radiat. Biol.
95
,
120
143
(
2019
).
9.
G. d. C. R.
Poiani
,
A. L.
Zaninotto
,
A. M. C.
Carneiro
 et al., “
Photobiomodulation using low-level laser therapy (LLLT) for patients with chronic traumatic brain injury: A randomized controlled trial study protocol
,”
Trials
19
,
1
8
(
2018
).
10.
F.
Salehpour
,
J.
Mahmoudi
,
F.
Kamari
,
S.
Sadigh-Eteghad
,
S. H.
Rasta
, and
M. R.
Hamblin
, “
Brain photobiomodulation therapy: A narrative review
,”
Mol. Neurobiol.
55
,
6601
6636
(
2018
).
11.
M.
Rosso
,
D.
Buchaim
,
N.
Kawano
,
G.
Furlanette
,
K.
Pomini
, and
R.
Buchaim
, “
Photobiomodulation therapy (PBMT) in peripheral nerve regeneration: A systematic review
,”
Bioengineering
5
,
44
56
(
2018
).
12.
G.
Shayeganrad
, “
An introduction to laser
,” in
Lasers in Oral and Maxillofacial Surgery
(
Springer
,
New York
,
2020
), pp.
9
23
.
13.
I.
Shivakoti
,
G.
Kibria
,
R.
Cep
,
B. B.
Pradhan
, and
A.
Sharma
, “
Laser surface texturing for biomedical applications: A review
,”
Coatings
11
,
124
139
(
2021
).
14.
S. Y.
Tam
,
V. C.
Tam
,
S.
Ramkumar
,
M. L.
Khaw
,
H. K.
Law
, and
S. W.
Lee
, “
Review on the cellular mechanisms of low-level laser therapy use in oncology
,”
Front. Oncol.
10
,
1255
1265
(
2020
).
15.
X.
Gao
,
W.
Zhang
,
F.
Yang
,
W.
Ma
, and
B.
Cai
, “
Photobiomodulation regulation as one promising therapeutic approach for myocardial infarction
,”
Oxid. Med. Cell. Longevity
2021
,
9962922
(
2021
).
16.
Q.
Peng
,
A.
Juzeniene
,
J.
Chen
,
L. O.
Svaasand
,
T.
Warloe
,
K.-E.
Giercksky
, and
J.
Moan
, “
Lasers in medicine
,”
Rep. Prog. Phys.
71
,
056701
(
2008
).
17.
X. C.
Muniz
,
A. C. C.
de Assis
,
B. S. A.
de Oliveira
,
L. F. R.
Ferreira
,
M.
Bilal
,
H. M.
Iqbal
and
R. N.
Soriano
, “
Efficacy of low-level laser therapy in nerve injury repair—A new era in therapeutic agents and regenerative treatments
,”
Neurol. Sci.
40
,
4029
4043
(
2021
).
18.
Avci,
Pinar
, et al., “
Low-level laser (light) therapy (LLLT) for treatment of hair loss
,”
Lasers Surg. and Med.
46
(
2
),
144
151
(
2014
).
19.
E.
Andreasson
and
S.
Lindgren
, Fysioterapeuters subjektiva upplevelse och erfarenhet av LLLT som behandlingsmetod vid muskelskada: En tvärsnittsstudie (Lulea Tekniska University publication, Swedish, 2021).
20.
A. L. C.
Martimbianco
,
R. E. S.
Ferreira
,
C. O. C.
Latorraca
,
S. K.
Bussadori
,
R. L.
Pacheco
, and
R.
Riera
, “
Photobiomodulation with low-level laser therapy for treating Achilles tendinopathy: A systematic review and meta-analysis
,”
Clin. Rehabilitation
34
,
713
722
(
2020
).
21.
S.
Farivar
,
T.
Malekshahabi
, and
R.
Shiari
, “
Biological effects of low level laser therapy
,”
J. Lasers Med. Sci.
5
,
58
62
(
2014
).
22.
A.
Fallah
,
A.
Mirzaei
,
N.
Gutknecht
, and
A. S.
Demneh
, “
Clinical effectiveness of low-level laser treatment on peripheral somatosensory neuropathy
,”
Lasers Med. Sci.
32
,
721
728
(
2017
).
23.
K. M.
AlGhamdi
,
A.
Kumar
, and
N. A.
Moussa
, “
Low-level laser therapy: A useful technique for enhancing the proliferation of various cultured cells
,”
Lasers Med. Sci.
27
,
237
249
(
2012
).
24.
da Silva
Câmara CN
,
M. V. H.
Brito
,
E. L.
Silveira
,
D. S. G.
da Silva
,
V. R. F.
Simões
, and
R. W. F.
Pontes
, “
Histological analysis of low-intensity laser therapy effects in peripheral nerve regeneration in Wistar rats
,”
Acta Cir. Bras.
26
,
12
18
(
2011
).
25.
M.
Rosso
,
D.
Buchaim
,
G.
Rosa Junior
,
J.
Andreo
,
K.
Pomini
, and
R.
Buchaim
, “
Low-level laser therapy (LLLT) improves the repair process of peripheral nerve injuries: A mini review
,”
Int. J. Neurorehabil.
4
,
1000260
(
2017
).
26.
Y.
Yuca
,
T.
Yucesoy
,
O. E.
Tok
, and
A.
Alkan
, “
The efficiency of ozone therapy and low-level laser therapy in rat facial nerve injury
,”
J. Cranio-Maxillofac. Surg.
48
,
308
314
(
2020
).
27.
P. d. T. C. d.
Carvalho
,
N.
Mazzer
,
F. A. d.
Reis
,
A. C. G.
Belchior
, and
I. S.
Silva
, “
Analysis of the influence of low-power HeNe laser on the healing of skin wounds in diabetic and non-diabetic rats
,”
Acta Cir. Bras.
21
,
177
183
(
2006
).
28.
F. d. P.
Eduardo
,
D. F.
Bueno
,
P. M.
de Freitas
,
M. M.
Marques
,
M. R.
Passos-Bueno
,
C. d. P.
Eduardo
, and
M.
Zatz
, “
Stem cell proliferation under low intensity laser irradiation: A preliminary study
,”
Lasers Surg. Med.
40
,
433
438
(
2008
).
29.
X.
Gao
and
D.
Xing
, “
Molecular mechanisms of cell proliferation induced by low power laser irradiation
,”
J. Biomed. Sci.
16
,
1
16
(
2009
).
30.
P. C.
Silveira
,
E. L.
Streck
, and
R. A.
Pinho
, “
Evaluation of mitochondrial respiratory chain activity in wound healing by low-level laser therapy
,”
J. Photochem. Photobiol. B
86
,
279
282
(
2007
).
31.
P. C.
Silveira
,
L. A. d.
Silva
,
D. B.
Fraga
,
T. P.
Freitas
,
E. L.
Streck
, and
R.
Pinho
, “
Evaluation of mitochondrial respiratory chain activity in muscle healing by low-level laser therapy
,”
J. Photochem. Photobiol. B
95
,
89
92
(
2009
).
32.
M. R.
Hamblin
, “
Mechanisms and mitochondrial redox signaling in photobiomodulation
,”
Photochemi. Photobiol.
94
,
199
212
(
2018
).
33.
Y. R.
Lee
,
H. K.
Joo
, and
B. H.
Jeon
, “
The biological role of apurinic/apyrimidinic endonuclease1/redox factor-1 as a therapeutic target for vascular inflammation and as a serologic biomarker
,”
Biomedicines
8
,
57
69
(
2020
).
34.
L. E. A.
Gomes
,
E. M.
Dalmarco
, and
E. S.
André
, “
The brain-derived neurotrophic factor, nerve growth factor, neurotrophin-3, and induced nitric oxide synthase expressions after low-level laser therapy in an axonotmesis experimental model
,”
Photomed. Laser Surg.
30
,
642
647
(
2012
).
35.
H.
Lian
,
Y.
Song
,
Y.
Jinglin
,
H.
Yang
,
Y.
Luo
, and
D.
Hongyan
, “
Effects of subthreshold micropulse yellow laser (577 nm) on VEGF, NGF and chemerin expressions in retina of early stage diabetic rats
,”
Recent Adv. Ophthalmol.
37
,
723
727
(
2017
).
36.
I.
Saygun
,
N.
Nizam
,
A. U.
Ural
,
M. A.
Serdar
,
F.
Avcu
, and
T. F.
Tözüm
, “
Low-level laser irradiation affects the release of basic fibroblast growth factor (bFGF), insulin-like growth factor-I (IGF-I), and receptor of IGF-I (IGFBP3) from osteoblasts
,”
Photomed. Laser Surg.
30
,
149
154
(
2012
).
37.
J.-S.
Kim
and
M.-H.
Rho
, “
Activation of IL-1β, IGF-1 and IGF-2 in injured rat skeletal muscle by low power He-Ne IR laser and electrical stimulation
,”
J. Korea Contents Assoc.
8
,
251
262
(
2008
).
38.
P. V.
Peplow
,
T.-Y.
Chung
,
B.
Ryan
, and
G. D.
Baxter
, “
Laser photobiomodulation of gene expression and release of growth factors and cytokines from cells in culture: A review of human and animal studies
,”
Photomed. Laser Surg.
29
,
285
304
(
2011
).
39.
A.
Amaroli
,
S.
Ferrando
, and
S.
Benedicenti
, “
Photobiomodulation affects key cellular pathways of all life-forms: Considerations on old and new laser light targets and the calcium issue
,”
Photochem. Photobiol.
95
,
455
459
(
2019
).
40.
T. Y.
Fukuda
,
M. M.
Tanji
,
S. R.
Silva
,
M. N.
Sato
, and
H.
Plapler
, “
Infrared low-level diode laser on inflammatory process modulation in mice: Pro-and anti-inflammatory cytokines
,”
Lasers Med. Sci.
28
,
1305
1313
(
2013
).
41.
H. M.
Ahmed
,
E.
Abu Taleb
, and
F. H.
Ameen
, “
High intensity laser therapy on pain in patients with myofascial trigger points
,”
Egypt. J. Phys. Ther.
3
,
1
8
(
2020
).
42.
M. S.
Al Musawi
and
B. T.
Al-Gailani
, “
ATP level in red blood cells improves by altering the low-level DPSS laser irradiation condition
,”
Appl. Nanosci.
28
,
1
7
(
2021
).
43.
H. B.
Cotler
,
R. T.
Chow
,
M. R.
Hamblin
, and
J.
Carroll
, “
The use of low level laser therapy (LLLT) for musculoskeletal pain
,”
MOJ Orthop. Rheumatol.
2
,
00068
(
2015
).
44.
M. B.
Ghayour
,
A.
Abdolmaleki
, and
M.
Behnam-Rassouli
, “
The effect of Riluzole on functional recovery of locomotion in the rat sciatic nerve crush model
,”
Eur. J. Trauma Emerg. Surg.
43
,
691
699
(
2017
).
45.
B. S.
Mietto
,
K.
Mostacada
, and
A. M. B.
Martinez
, “
Neurotrauma and inflammation: CNS and PNS responses
,”
Mediators Inflamm.
2015
,
1
14
(
2015
).
46.
E. A.
Huebner
and
S. M.
Strittmatter
, “
Axon regeneration in the peripheral and central nervous systems
,”
Cell Biol. Axon
48
,
305
360
(
2009
).
47.
M. B.
Ghayour
,
A.
Abdolmaleki
, and
M. B.
Rassouli
, “
Neuroprotective effect of Lovastatin on motor deficit induced by sciatic nerve crush in the rat
,”
Eur. J. Pharmacol.
812
,
121
127
(
2017
).
48.
C. C.
Medalha
,
G. C.
Di Gangi
,
C. B.
Barbosa
,
M.
Fernandes
,
O.
Aguiar
,
F.
Faloppa
,
V. M.
Leite
, and
A. N. C. M.
Renno
, “
Low-level laser therapy improves repair following complete resection of the sciatic nerve in rats
,”
Lasers Med. Sci.
27
,
629
635
(
2012
).
49.
S.
Rochkind
,
L.
Leider-Trejo
,
M.
Nissan
,
M. H.
Shamir
,
O.
Kharenko
, and
M.
Alon
, “
Efficacy of 780-nm laser phototherapy on peripheral nerve regeneration after neurotube reconstruction procedure (double-blind randomized study)
,”
Photomed. Laser Surg.
25
,
137
143
(
2007
).
50.
F. J.
Dias
,
V. P. S.
Fazan
,
D. P.
Cury
,
S. R. Y.
de Almeida
,
E.
Borie
,
R.
Fuentes
,
J.
Coutinho-Netto
, and
L.-S.
Watanbe
, “
Growth factors expression and ultrastructural morphology after application of low-level laser and natural latex protein on a sciatic nerve crush-type injury
,”
PLoS One
14
,
e0210211
(
2019
).
51.
M.
Mashhoudi Barez
,
M.
Tajziehchi
,
M. H.
Heidari
,
A.
Bushehri
,
F.
Moayer
,
N.
Mansouri
,
N. S.
Naini
, and
A.
Movafagh
, “
Stimulation effect of low level laser therapy on sciatic nerve regeneration in rat
,”
J. Lasers Med. Sci.
8
,
S32
S37
(
2017
).
52.
A. M.
Al-Shammari
,
Y.
Syhood
, and
A. S.
Al-Khafaji
, “
Use of low-power He-Ne laser therapy to accelerate regeneration processes of injured sciatic nerve in rabbit
,”
Egypt. J. Neurol. Psychiatry Neurosurg.
55
,
1
7
(
2019
).
53.
C.-Z.
Wang
,
Y.-J.
Chen
,
Y.-H.
Wang
 et al., “
Low-level laser irradiation improves functional recovery and nerve regeneration in sciatic nerve crush rat injury model
,”
PLoS One.
9
,
e103348
(
2014
).
54.
G. R. F.
Bertolini
,
E. L.
Artifon
,
T. S.
da Silva
,
D. M.
Cunha
, and
P. R.
Vigo
, “
Low-level laser therapy, at 830 nm, for pain reduction in experimental model of rats with sciatica
,”
Arq. Neuro-psiquiatr.
69
,
356
359
(
2011
).
55.
C.-C.
Shen
,
Y.-C.
Yang
,
T.-B.
Huang
,
S.-C.
Chan
, and
B.-S.
Liu
, “
Low-level laser-accelerated peripheral nerve regeneration within a reinforced nerve conduit across a large gap of the transected sciatic nerve in rats
,”
Evid Based Complement. Alternat. Med.
2013
,
175629
(
2013
).
56.
A.
Sarveazad
,
A.
Janzadeh
,
G.
Taheripak
,
S.
Dameni
,
M.
Yousefifard
, and
F.
Nasirinezhad
, “
Co-administration of human adipose-derived stem cells and low-level laser to alleviate neuropathic pain after experimental spinal cord injury
,”
Stem Cell Res. Ther.
10
,
183
(
2019
).
57.
J. W.
Song
,
K.
Li
,
Z. W.
Liang
 et al., “
Low-level laser facilitates alternatively activated macrophage/microglia polarization and promotes functional recovery after crush spinal cord injury in rats
,”
Sci. Rep.
7
,
1
13
(
2017
).
58.
B.
Biglari
,
T.
Swing
,
C.
Child
 et al., “
A pilot study on temporal changes in IL-1β and TNF-α serum levels after spinal cord injury: The serum level of TNF-α in acute SCI patients as a possible marker for neurological remission
,”
Spinal Cord
53
,
510
514
(
2015
).
59.
Y.
Li
,
H.
Qiu
,
S.
Yao
 et al., “
Geniposide exerts protective effects on spinal cord injury in rats by inhibiting the IKKs/NF-κB signaling pathway
,”
Int. Immunopharmacol.
100
,
108158
(
2021
).
60.
S.
Veronez
,
L.
Assis
,
P.
Del Campo
,
F.
de Oliveira
,
G.
de Castro
,
A. C. M.
Renno
and
C. C.
Medalha
, “
Effects of different fluences of low-level laser therapy in an experimental model of spinal cord injury in rats
,”
Lasers Med. Sci.
32
,
343
349
(
2017
).
61.
Y.
Gong
,
S.
Wang
,
Z.
Liang
 et al., “
Label-free spectral imaging unveils biochemical mechanisms of low-level laser therapy on spinal cord injury
,”
Cell. Physiol. Biochemi.
49
,
1168
1183
(
2018
).
62.
J.
Kim
,
E.-H.
Kim
,
K.
Lee
,
B.
Kim
,
Y.
Kim
,
S. H.
Na
and
Y. W.
Yoon
, “
Low-level laser irradiation improves motor recovery after contusive spinal cord injury in rats
,”
Tissue Eng. Regen. Med.
14
,
57
64
(
2017
).
63.
J.
Zhang
,
J.
Sun
,
Q.
Zheng
 et al., “
Low-level laser therapy 810-nm up-regulates macrophage secretion of neurotrophic factors via PKA-CREB and promotes neuronal axon regeneration in vitro
,”
J. Cell. Mol. Med.
24
,
476
487
(
2020
).
64.
A.
Sotoudeh
,
A.
Jahanshahi
,
S.
Zareiy
,
M.
Darvishi
,
N.
Roodbari
, and
A.
Bazzazan
, “
The influence of low-level laser irradiation on spinal cord injuries following ischemia-reperfusion in rats
,”
Acta Cir. Bras.
30
,
611
616
(
2015
).
65.
U.
Raghavendra
,
A.
Gudigar
,
V.
Vidhya
 et al., “
Novel and accurate non-linear index for the automated detection of haemorrhagic brain stroke using CT images
,”
Complex Intell. Syst.
7
,
929
940
(
2021
).
66.
D.
Mozaffarian
,
E. J.
Benjamin
,
A. S.
Go
 et al., “
Heart disease and stroke statistics-2016 update: A report from the American Heart Association
,”
Circulation
133
,
e38
e360
(
2016
).
67.
F.
Ashrafi
,
A.
Rezaei
,
A.
Azhideh
 et al., “
Effectiveness of extremely low frequency electromagnetic field and pulsed low level laser therapy in acute stroke treatment
,”
Int. Clin. Neurosci. J.
7
,
127
131
(
2020
).
68.
N.
Hakimiha
,
M. M.
Dehghan
,
H.
Manaheji
,
J.
Zaringhalam
,
S.
Farzad-Mohajeri
,
R.
Fekrazad
, and
N.
Moslemi
, “
Recovery of inferior alveolar nerve by photobiomodulation therapy using two laser wavelengths: A behavioral and immunological study in rat
,”
J. Photochem. Photobiol. B
204
,
111785
(
2020
).
69.
J.
Jittiwat
, “
Laser acupuncture at GV20 improves brain damage and oxidative stress in animal model of focal ischemic stroke
,”
J. Acupunct. Meridian Stud.
10
,
324
330
(
2017
).
70.
Y.
Lampl
,
J. A.
Zivin
,
M.
Fisher
 et al., “
Infrared laser therapy for ischemic stroke: A new treatment strategy: Results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1)
,”
Stroke
38
,
1843
1849
(
2007
).
71.
K.
Yip
,
S.
Lo
,
M.
Leung
,
K.
So
,
C. Y.
Tang
, and
D.
Poon
, “
The effect of low-energy laser irradiation on apoptotic factors following experimentally induced transient cerebral ischemia
,”
Neuroscience
190
,
301
306
(
2011
).
72.
S.
Song
,
F.
Zhou
, and
W. R.
Chen
, “
Low-level laser therapy regulates microglial function through Src-mediated signaling pathways: Implications for neurodegenerative diseases
,”
J. Neuroinflammation
9
,
1
17
(
2012
).
73.
L.
Shen
, “
Gut, oral and nasal microbiota and Parkinson’s disease
,”
Microb. Cell Fact.
19
,
50
(
2020
).
74.
J.
Jankovic
, “
Parkinson’s disease: Clinical features and diagnosis
,”
J. Neurol. Neurosurg. Psychiatry
79
,
368
376
(
2008
).
75.
K. F.
Winklhofer
and
C.
Haass
, “
Mitochondrial dysfunction in Parkinson’s disease
,”
Biochim. Biophys. Acta Mol. Basis Dis.
1802
,
29
44
(
2010
).
76.
A. S. C.
Foo
,
T. W.
Soong
,
T. T.
Yeo
, and
K.-L.
Lim
, “
Mitochondrial dysfunction and Parkinson’s disease—Near-infrared photobiomodulation as a potential therapeutic strategy
,”
Front. Aging Neurosci.
12
,
89
102
(
2020
).
77.
P. A.
Trimmer
,
K. M.
Schwartz
,
M. K.
Borland
,
L.
De Taboada
,
J.
Streeter
, and
U.
Oron
, “
Reduced axonal transport in Parkinson’s disease cybrid neurites is restored by light therapy
,”
Mol. Neurodegener.
4
,
1
11
(
2009
).
78.
F.
Salehpour
and
M. R.
Hamblin
, “
Photobiomodulation for Parkinson’s disease in animal models: A systematic review
,”
Biomolecules
10
,
610
629
(
2020
).
79.
G.
Hassanshahi
,
M. A.
Roohi
,
S.-A.
Esmaeili
,
H.
Pourghadamyari
, and
R.
Nosratabadi
, “
Involvement of various chemokine/chemokine receptor axes in trafficking and oriented locomotion of mesenchymal stem cells in multiple sclerosis patients
,”
Cytokine
148
,
155706
(
2021
).
80.
R.
Dobson
and
G.
Giovannoni
, “
Multiple sclerosis–A review
,”
Eur. J. Neurol.
26
,
27
40
(
2019
).
81.
A.
Bar-Or
,
M. P.
Pender
,
R.
Khanna
 et al., “
Epstein–Barr virus in multiple sclerosis: Theory and emerging immunotherapies
,”
Trends Mol. Med.
26
,
296
310
(
2020
).
82.
E. D.
Gonçalves
,
P. S.
Souza
,
V.
Lieberknecht
,
G. S.
Fidelis
,
R. I.
Barbosa
,
P. C.
Silveira
,
R. A.
de Pinho
, and
R. C.
Dutra
, “
Low-level laser therapy ameliorates disease progression in a mouse model of multiple sclerosis
,”
Autoimmunity
49
,
132
142
(
2016
).
83.
H.
Inojosa
,
D.
Schriefer
, and
T.
Ziemssen
, “
Clinical outcome measures in multiple sclerosis: A review
,”
Autoimmun. Rev.
19
,
102512
(
2020
).
84.
G. K.
Pramanik
, Cortical Hyperactivity Beyond Immune Attack: Pivotal Role of TNF-alpha in Early Multiple Sclerosis (Johannes Gutenberg, Mainz, 2017).
85.
K. C. N.
Duarte
,
T. T.
Soares
,
A. M. P.
Magri
,
L. A.
Garcia
,
L.
Le Sueur-Maluf
,
A. C. M.
Renno
, and
G. M.
de Castro
, “
Low-level laser therapy modulates demyelination in mice
,”
J. Photochem. Photobiol. B
189
,
55
65
(
2018
).
86.
T.
Silva
,
Y. D.
Fragoso
,
M. F. S.
Destro Rodrigues
 et al., “
Effects of photobiomodulation on interleukin-10 and nitrites in individuals with relapsing-remitting multiple sclerosis—Randomized clinical trial
,”
PLoS One
15
,
e0230551
(
2020
).
87.
R. E.
von Leden
,
S. J.
Cooney
,
T. M.
Ferrara
 et al., “
808 nm wavelength light induces a dose-dependent alteration in microglial polarization and resultant microglial induced neurite growth
,”
Lasers Surg. Med.
45
,
253
263
(
2013
).
88.
A.
Serrano-Pozo
,
M. P.
Frosch
,
E.
Masliah
, and
B. T.
Hyman
, “
Neuropathological alterations in Alzheimer disease
,”
Cold Spring Harbor Perspect. Med.
1
,
a006189
(
2011
).
89.
O.
Kaidanovich-Beilin
and
J. R.
Woodgett
, “
Glycogen synthase kinase-3 in neurological diseases
,” in
Protein Kinase Technologies
(Humana Press, Totowa, NJ,
2012
), pp.
153
188
.
90.
D.-Y.
Tian
,
Y.
Cheng
,
Z.-Q.
Zhuang
 et al., “
Physiological clearance of amyloid-beta by the kidney and its therapeutic potential for Alzheimer’s disease
,”
Mol. Psychiatry
130
,
487
499
(
2021
).
91.
L.
Vaillant-Beuchot
,
A.
Mary
,
R.
Pardossi-Piquard
 et al., “
Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer’s disease models and human brains
,”
Acta Neuropathol.
141
,
39
65
(
2021
).
92.
Y.
Lu
,
R.
Wang
,
Y.
Dong
 et al., “
Low-level laser therapy for beta amyloid toxicity in rat hippocampus
,”
Neurobiol. Aging
49
,
165
182
(
2017
).
93.
F. d. S.
Cardoso
,
R. Á. B.
Lopes Martins
, and
S.
Gomes da Silva
, “
Therapeutic potential of photobiomodulation in Alzheimer’s disease: A systematic review
,”
J. Lasers Med. Sci.
11
,
S16
S22
(
2020
).
94.
L.
De Taboada
,
J.
Yu
,
S.
El-Amouri
,
S.
Gattoni-Celli
,
S.
Richieri
,
T.
McCarthy
,
J.
Streeter
, and
M. K.
Kindy
, “
Transcranial laser therapy attenuates amyloid-β peptide neuropathology in amyloid-β protein precursor transgenic mice
,”
J. Alzheimer’s Dis.
23
,
521
535
(
2011
).
95.
A.
Oron
and
U.
Oron
, “
Low-level laser therapy to the bone marrow: A new therapeutic approach to neurodegenerative diseases
,” in
Photobiomodulation in the Brain
(
Elsevier
,
New York
,
2019
), pp.
213
217
.
96.
Z.
Zhang
,
Q.
Shen
,
X.
Wu
,
D.
Zhang
, and
D.
Xing
, “
Activation of PKA/SIRT1 signaling pathway by photobiomodulation therapy reduces Aβ levels in Alzheimer’s disease models
,”
Aging Cell
19
,
e13054
(
2020
).
97.
Q.
Shen
,
L.
Liu
,
X.
Gu
, and
D.
Xing
, “
Photobiomodulation suppresses JNK3 by activation of ERK/MKP7 to attenuate AMPA receptor endocytosis in Alzheimer’s disease
,”
Aging Cell
20
,
e13289
(
2021
).
98.
C.
Meng
,
Z.
He
, and
D.
Xing
, “
Low-level laser therapy rescues dendrite atrophy via upregulating BDNF expression: Implications for Alzheimer’s disease
,”
J. Neurosci.
33
,
13505
13517
(
2013
).
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