Biological threshold retinal injury is believed to be caused by the predictable denaturization of protein. A retinal thermal computer model which calculates temperature rises and predicts single-pulsed threshold injury based on a 50-percent denaturization of the available proteins is studied to determine if it can match measured biological thresholds for repetitive pulsed lasers.
REFERENCES
1.
Allen
R.G.
(1980
) Retinal thermal injury
in (Sliney
D.H.
and Wolbarsht
M.L.
, eds.) Ocular Effects of Nonionizing Radiation, Proc
. SPIE
, 229
:81
–86
.2.
Barnes
F.S.
(1974
) Biological damage resulting from thermal pulses, in (M.L.
Wolbarsht
, ed.) Laser Applications in Medicine and Biology
, Vol 2
, pp 205
–221
, New York
, Plenum Press
.3.
Birngruber
R.
, Hillenkamp
F.
, Gabel
V.P.
(1985
) Theoretical investigations of laser thermal retinal injury
, Health Phys
, 48
:781
–796
.4.
Chan
G.
, Berry
E.R.
, Geeraets
W.J.
(1963
) Alterations of soluble retinal proteins due to thermal injury
, Acta Ophthalmolgica
(Supppl.) 76
:101
–108
.5.
Clarke
A.M.
, Geeraets
W.J.
, Ham
W.T.
(1969
) An equilibrium thermal model for retinal injury
, Appl Opt
, 8
:1051
–1054
.6.
Gabay
S.
, Kremer
I.
, Ben-Sira
I.
, Erez
G.
(1988
) Retinal thermal response to copper-vapor laser exposure
, Lasers Surg Med
, 8
:418
–427
.7.
Hayes
J.R.
, Wolbarsht
M.L.
(1968
) Thermal model for retinal damage induced by pulsed lasers
, Aerospace Med
, 39
:474
–480
.8.
Henriques
F.C.
(1947
) Studies of thermal injury, the predictability and the significance of thermally induced rate processes leading to irreversible epidermal injury
. Arch Pathol
, 43
:489
–502
.9.
Hillenkamp
F.
(1989
) Laser radiation tissue interaction
, Health Phys
, 56
(5
):613
–616
.10.
Mainster
M.A.
, White
T.J.
, Tips
J.H.
, Wilson
P.W.
(1970a
) Transient thermal behavior in biological systems
, Bull Math Biophys
, 32
:303
–314
.11.
Mainster
M.A.
, White
T.J.
, Tips
J.H.
, Wilson
P.W.
(1970b
) Retinal-temperature increases produced by intense light sources
, J Opt Soc Am
60
:264
–270
.12.
Mellerio
J.
(1966
) The thermal nature of retinal laser photocoagulation
, Exp Eye Res
5
:242
–248
.13.
Roulier
A.
(1970
) Calculations of temperature increase in the eye produced by intense light
, Bull Math Biophys
, 32
:403
–427
.14.
Stuck
B.E.
(1978
) “Repetitive Pulse Laser Data and Permissible Exposure Limits
,” Institute Report No. 58
, Division of Non-Ionizing Radiation, Letterman Army Institute of Research
, San Francisco, California
.15.
Vassiliadis
A.
(1971
) Ocular damage from laser radiation, in (M.L.
Wolbarsht
, ed.) Laser Applications in Medicine and Biology
, Vol 1
, pp 125
–162
, New York
, Plenum Press.
SECTION 4-22 Nov
. 1990 ILSC16.
Vos
J.J.
(1962
) A theory of retinal burns
, Bull Math Biophys
, 24
:115
–128
.17.
Welch
A.J.
(1984
) Thermal response of laser-irradiated tissue
, IEEE J Quant Electr
, QE-20
: 1471
–1481
.18.
Welch
A.J.
, Priebe
L.A.
, Forster
L.D.
, Gilbert
R.
, Lee
C.
, Drake
P.
(1979
) “Experimental Validation of Thermal Retinal Models of Damage from Laser Radiation
,” Report SAM-TR-79-9
, USAF School of Aerospace Medicine
, Brooks AFB, TX 78235
.19.
White
T.J.
, Mainster
M.A.
, Tips
J.H.
, Wilson
P.W.
(1970
) Chorioretinal thermal behavior
, Bul Math Biophys
, 32
:315
–322
.
This content is only available via PDF.
© 1991 Laser Institute of America.
1991
Laser Institute of America
You do not currently have access to this content.