In order to explore the alternative use of cynomolgus (Macaca fasicularis) as a substitute for the ubiquitous rhesus monkey (Macaca mulatta) as a model for retinal damage, a series of “bridging” experiments utilizing visible lasers (413 nm, 532 nm and 647 nm) has been initiated. Exposure conditions conducive to both photochemical and photothermal damage mechanisms have been explored with parameters that were similar to those used in previous studies which had employed the rhesus model. The damage threshold results of past and current studies around these three wavelengths are compared here and recommendations for additional studies are indicated.
REFERENCES
1.
D.B.
Tata
, D. J.
Stolarski
, K. J.
Schuster
, M. L.
Imholte
, H. M.
Hodnett
, J. W.
Frakes
, V.
Carothers
and B. A.
Rockwell
, “Photochemical and Thermal Retinal Damage Thresholds from an Extended (413nm) Krypton Laser Source
,” in International Laser Safety Conference
, pp. 36
–41
(2005
).2.
P. W.
Lappin
, “Ocular Damage Thresholds for the Helium-Neon Laser
,” Archives of Environmental Health
20
(177
–183
(1970
)3.
Y.
Onda
and T.
Kameda
, “Studies of Laser Hazards and Safety Standards (Part 2: Retinal Damage Thresholds for Helium-Neon Lasers)
,” U. S. Army Intelligence and Information Agency
(1980
).4.
W. T.
Ham
, H. A.
Mueller
, J. J.
Ruffolo
and A. M.
Clarke
, “Sensitivity of the Retina to Radiation Damage as a Function of Wavelength
,” Photochemistry and Photobiology
29
(735
–743
(1979
)5.
M. L.
Denton
, C. D.
Clark
, M. S.
Foltz
, K. J.
Schuster
, G. D.
Noojin
, L. E.
Estlack
and R. J.
Thomas
, “In-vitro retinal model reveals a sharp transition between laser damage mechanisms
,” J Biomed Opt
15
(3
), 030512
(2009
)6.
J.
Zuclich
, J.
Yates
, A.
Nawrocki
, W.
Bowie
and R.
Lemberger
, “Research on the ocular effects of laser radiation
,” (1977
)7.
Y.
Onda
and T.
Kameda
, “Studies of Laser Hazards and Safety Standards (Part 3: Retinal Damage Thresholds for Argon Lasers)
,” U. S. Army Intelligence and Information Agency
(1980
).8.
A.
Vassiliadis
, R. C.
Rosan
and H. C.
Zweng
, “Research on Ocular Laser Thresholds
,” Stanford Research Institute
(1969
).9.
J. S.
Connolly
, H. W.
Hemstreet
and D. E.
Egbert
, “Ocular hazards of picosecond and repetitive pulsed lasers, Vol II: Argon-Ion laser (514.5nm)
,” USAF School of Aerospace Medicine
(1978
).10.
11.
J. A.
Zuclich
and M. F.
Blankenstein
, “Additivity of retinal damage for multiple-pulse laser exposures
,” USAF School of Aerospace Medicine
(1988
).12.
D. J.
Lund
, P. R.
Edsall
, D.
R. Fuller
and S.
W. Hoxie
, “Ocular Hazards of Tunable Continuous-Wave Near-Infrared Laser Sources,” in Progress in Biomedical Optics (BiOS)
B.
E. Stuck
and M.
Belkin
, Eds., pp. 53
–61
, SPIE
, San Jose, CA
(1996
).13.
D. J.
Lund
, D. R.
Fuller
, S. W.
Hoxie
and P. R.
Edsall
, “Variation of retinal ED50 with exposure duration for near-IR sources,” in Laser and Noncoherent Ocular Effects: Epidemiology, Prevention, and Treatment
B. E.
Stuck
and M.
Belkin
, Eds., pp. 51
–59
, SPIE
, San Jose, CA
(1997
).14.
W. T.
Ham
, W. J.
Geeraets
, H. A.
Mueller
, R. C.
Williams
, A. M.
Clarke
and S. F.
Cleary
, “Retinal burn thresholds for the helium-neon laser in the rhesus monkey
.,” Archives of Ophthalmology
84
(797
–809
(1970
)15.
W. D.
Gibbons
and R. G.
Allen
, “Retinal damage from long-term exposure to laser radiation
,” Investigative Ophthalmology and Visual Science
16
(6
), 521
–529
(1977
)16.
T.
Davis
, W.
Mautner
, EG and G. I. L. A. C. S. M. DIV., “HELIUM NEON LASER EFFECTS ON THE EYE
,” Defense Technical Information Center
(1969
).17.
18.
J.
Oliver
, D.
Stolarski
, G.
Noojin
, H.
Hodnett
, M.
Imholte
, B.
Rockwell
, S.
Kumru
and A. F. R. L. B. A T. O. RADIATION, “Visible lesion laser thresholds in cynomolgus (Macaca fascicularis) retina with a 1064-nm, 12-ns pulsed laser
,” (2007
)
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