A better understanding of immunological donor-recipient incompatibility has encouraged the use of blood and its components. In 1985, an estimated 10 million units of whole blood were processed by over 800 blood banks in the United States and 14 million units of blood components were transfused. This increase reflects major advances in managing trauma, hemorrhagic and neoplastic disorders, and recipients of bone marrow or solid organ transplants. Use of blood products still involves significant risk to the recipient because of the potential for transmitting infectious agents. Hepatitis B virus (HBV); cytomegalovirus (CMV); Epstein-Barr virus (EBV); human T cell lymphotropic virus, type 1 (HTLV-1); non-A, non-B (NANB) hepatitis virus; human immunodeficiency virus (HIV); malaria; and trypanosomes can be transmitted by blood transfusion. Screening of donors and serologic testing reduce the risk, but these precautions still provide insufficient protection since detectable HIV antibody may not be present during the early stage of infection.

1.
Fuller
,
T.C.
,
C.E.
Huggins
and
P.S.
Russel
1975
. Book of Abstracts.
XIV Congress of the International Society of Blood Transfusion
.
Helsinki, Finland
, p
63
.
2.
Personal communication
1987
.
American Association of Blood Banks
,
National Office
,
Arlington, VA
, to Dr. Alain Marengo-Rowe, BUMC.
3.
Colli
,
W.
1979
. Chagas’ disease. In
The Membrane Pathology of Tropical Disease
. ed.
Wallach
,
D.F.H.
, pp.
131
153
.
Basel
,
Schwabe
.
4.
Alter
,
H.J.
,
P.V.
Holland
,
R.H.
Purcell
, et al
1972
.
Posttransfusion hepatitis after exclusion of commercial and hepatitis-B antigen-positive donors
.
ANN INTERN MED
77
:
691
699
.
5.
Feinstone
,
S.M.
,
A.Z.
Kapikian
,
R.H.
Purcell
, et al
1975
.
Transfusion-associated hepatitis not due to viral hepatitis type A or B
.
N ENGL J MED
292
:
767
770
.
6.
Prince
,
A.M.
,
W.
Szmumess
,
S.J.
Millian
, et al
1971
.
A serologic study of cytomegalovirus infections associated with blood transfusion
.
N ENGL J MED
284
:
1125
1131
.
7.
Gerber
,
P.
,
J.H.
Walsh
,
E.N.
Rosenblum
, et al
1969
.
Association of EB-virus infection with the post-perfusion syndrome
.
LANCET
1
:
593
595
.
8.
Enck
,
R.E.
,
M.R.
Brown
,
R.F.
Betts
, et al
1979
.
Viral serology (hepatitis B virus, cytomegalovirus, Epstein-Barr virus) and abnormal liver tests in transfused patients with hereditary hemorrhagic diseases
.
TRANSFUSION
19
:
32
38
.
9.
Curran
,
J.W.
,
D.N.
Lawrence
and
H.
Jaffe
1984
.
Acquired immunodeficiency syndrome (AIDS) associated with transfusions
.
N ENGL J MED
310
:
69
75
.
10.
Goldfield
,
M.
1975
. Some epidemiologic studies of transfusion-associated hepatitis. In
Transmissible Disease and Blood Transfusion
. eds.
Greenwalt
T.J.
,
G.A.
Jamieson
.
Grune and Stratton
,
New York City
, pp
141
151
.
11.
Junet
,
R.
and
W.
Junet
1938
.
Ictere infectieux transmis par un donneur de sang
.
REVUE MEDICAL de la SUISSE ROMANDE
58
:
537
546
.
12.
Groopman
,
J.E.
,
P.I.
Hartzband
,
L.
Shulman
, et al
1985
.
Antibody seronegative human T-lymphotrophic virus type III (HTLV-III)-infected patients with acquired immunodeficiency syndrome related disorders
.
BLOOD
66
:
742
744
.
13.
Dougherty
,
T.J.
1983
. Photoradiation therapy: Clinical and drug advances. BLOOD 66: 742-744. In
PHOTOSENSITIZATION
, eds.
Kessel
D.
,
T.J.
Dougherty
.
Plenum Press
,
New York City
, pp
3
13
.
14.
Weishaupt
,
K.R
,
L.J.
Gomer
and
T.J.
Dougherty
1976
.
Identification of singlet oxygen as the cytotoxic agent in photoinactivation of a murine tumor
.
CANCER RES
36
:
2326
2329
.
15.
Newman
,
J.T.
,
J.L.
Matthews
,
F.
Sogandares-Bemal
,
M.M.
Judy
,
H.L.
Skiles
,
J.E.
Leveson
,
A.J.
Marengo-Rowe
,
T.C.
Chanh
and
G.
Dreesman
1988
.
Photodynamic inactivation of viruses and its application for blood banking
.
BUMC PROCEEDINGS
1
(
2
):
3
14
.
16.
Skiles
,
H.
,
M.M.
Judy
and
J.T.
Newman
1985
. Photodynamic inactivation of viruses with hematoporphyrin derivative, Abstract,
American Society for Microbiology
,
Washington, D.C.
, A38, p. 37.
17.
Sogandares-Bemal
,
F.
,
J.L.
Matthews
,
H.L.
Skiles
,
M.M.
Judy
and
J.T.
Newman
1987
. Photoinactivation of herpes simplex virus by Photofrin II and light in a flow cell system, Abstract,
American Society for Microbiology
,
Washington, D.C.
, A95, p.
16
.
18.
Matthews
,
J.L.
,
J.T.
Newman
,
F.
Sogandares-Bernal
, et al
1988
.
Photodynamic therapy of viral contaminants with potential for blood banking applications
,
TRANSFUSION
28
(
1
):
82
.
19.
Matthews
,
J.L.
,
F.
Sogandares-Bernal
,
M.M.
Judy
,
A.J.
Marengo-Rowe
,
H.L.
Skiles
,
J.E.
Leveson
,
T.C.
Chanh
and
J.T.
Newman
1988
.
Photodynamic inactivation of human immunodeficiency virus in blood
, Abstract,
American Association of Blood Banks
. In press.
20.
Schmidt
,
N.J.
1979
. Cell culture techniques for diagnostic virology.
In Diagnostic Procedures for Viral. Rickettsial and Chlamydial Infections
, eds.
Lennette
E.H.
,
J.J.
Schmidt
. 5th ed.
American Public Health Association
,
Washington, DC
. pp
104
110
.
21.
Chanh
,
T.
,
G.
Dreesman
,
P.
Kanda
, et al
1986
.
Induction of anti-HIV neutralizing antibodies by synthetic peptides
.
EMBO J
5
:
3065
3071
.
22.
Clauss
,
A.
1957
.
Rapid physiological coagulation method in determination of fibrinogen
.
ACTA HAEMATOLOGICA
17
:
237
246
.
23.
Dacie
,
J.V.
and
S.M.
Lewis
1975
. Laboratory methods used in investigation of haemolytic anaemias. II. Hereditary anaemia. In
Practical Haematology
, 5th ed.
Churchill Livingstone
,
London and New York City
, pp
202
235
.
24.
Dacie
,
J.V.
and
S.M.
Lewis
1975
. Laboratory methods used in investigation of haemolytic anaemias. V. Paroxysmal nocturnal hemoglobinuria (PNH). In
Practical Haematology
. 5th ed.
Churchill Livingstone
,
London and New York City
, pp
304
313
.
25.
Blough
,
H.A.
and
J.M.
Tiffany
1980
. Composition and function of viral lipids. In CELL MEMBRANES AND VIRAL ENVELOPES 2. eds.
Blough
,
H.A.
,
J.M.
Tiffany
.
Academic Press
,
New York City
, pp
459
493
.
26.
Ho
,
D.D.
,
R.J.
Pomerantz
and
J.C.
Kaplan
1987
.
Pathogenesis of infection with human immunodeficiency virus
.
N ENGL J MED
317
:
278
286
.
27.
Folks
,
T.
,
D.M.
Powell
,
M.M.
Lightfoote
, et al
1986
.
Induction of HTLV-III/LAV from a nonvirus-producing T cell line: Implication for latency
.
SCIENCE
231
:
600
602
.
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