The following biological systems and physiologic processes were influenced by a variety of low-output lasers:

  1. Repeated laser irradiation of the skin

  2. Hair growth in depilated mice

  3. Phagocytosis of bacteria by human and rat leukocytes

  4. Spontaneous activity of jejunal villi in dogs

  5. Neurotransmitter release following ruby laser exposure in guinea-pig ileum

  6. DNA and RNA content in ruby laser irradiated Escherichia coli cultures

  7. Laser irradiation on Ehrlich’s ascites tumor cells

  8. Remote effect of laser irradiation on vessel formation in rabbit cornea

  9. Low-output laser irradiation and wound healing:

    • electronmicroscopy of granulation tissue: collagen production in fibroblasts

    • enzymatic events in the early stages of wound healing

    • regeneration of microcirculation in rabbit ear

    • regeneration of muscle fiber

    • tensile strength of He-Ne laser-irradiated wounds in rat’s skin

    • immunosuppressive effect of laser-irradiation:

      • skin allotransplant survival time in rat

      • blast formation of phytohemagglutine stimulated lumphocytes

      • effect of noncoherent light sources on T and B lymphocytes

    • prostaglandin content in wounded dorsal skin of the rat

Biostimulatory effects of low-output laser irradiation have been demonstrated at a variety of molecular and cellular levels, as well as at whole organ and tissue levels. Under certain circumstances, syner-gistic effects with laser irradiation have been demonstrated; e.g. an effect on the immune system. Evidence exists which indicate that effects remote to the irradiated site occur, suggesting the presence of a circulatory active substance. Furthermore, the biostimulatory effects of low-output laser irradiation are dose dependent and, with sufficient intensity, the stimulatory effect disappears and inhibition occurs.

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