The use of low energy lasers to accelerate wound healing continues to produce controversies. Some studies using cellular in vitro systems and animal models suggest that non-thermal laser irradiation can stimulate certain biochemical processes or physiological phenomena that might be related to wound healing. At the same time negative results are obtained in other studies using similar systems. The available information seems to indicate that the stimulation phenomena may occur for limited ranges of laser exposures and at specific sets of experimental parameters. At the same time, evaluation of the material reporting biostimulation phenomena is severely hampered by insufficient information on the protocols used, in particular on the exposure parameters. These deficiencies make it very difficult to objectively evaluate the status of the area of laser biostimulation.

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1988
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