Pathogenesis of acute ocular hypertension after laser trabeculoplasty Available to Purchase

The effects of indomethacin on the acute rise of intraocular pressure (IOP) following argon laser irradiation of the iris and trabecular meshwork in pigmented rabbits have been studied. Acute pressure elevation of at least 12 mm Hg was noted in the experimental eye 15 minutes after photocoagulating either the iris or the angle meshwork. The pressure elevations lasted for more than two hours and were followed by a delayed hypotony at 24 hours. Prior treatment (1 hour) with indomethacin (30 mg/kg, IP) prevented the acute pressure rise following irradiation of the iris, but only partially blocked the pressor response after lasering the angle meshwork. These results suggest that prostaglandins (PG’s) are involved in mediating the IOP rise following iridotomy. In contrast, the role of PG’s in mediating the rise in IOP after lasering the trabecular meshwork in the rabbit remains unclear.