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Microphysiological Systems

In recognition of the importance of this growing field, Associate Editor Roger Kamm and Guest Editors Dan Huh and James Hickman present a collection of papers that highlight the current and future capabilities of microphysiological systems over a wide range of topics, from basic research to translation into practice.

Guest Editors: Roger Kamm, Dan Huh, and James Hickman

ARTICLES

Remodeling of an in vitro microvessel exposed to cyclic mechanical stretch

Soheila Zeinali; Emily K. Thompson; Holger Gerhardt; Thomas Geiser; Olivier T. Guenat

https://doi.org/10.1063/5.0010159

ARTICLES

AAV-mediated gene therapy targeting TRPV4 mechanotransduction for inhibition of pulmonary vascular leakage

Juan Li; Amy M. Wen; Ratnakar Potla; Ezekiel Benshirim; Ariel Seebarran; Maximilian A. Benz; Olivier Y. F. Henry; Benjamin D. Matthews; Rachelle Prantil-Baun; Sarah E. Gilpin; Oren Levy; Donald E. Ingber

https://doi.org/10.1063/1.5122967

REVIEWS

Microphysiological systems modeling acute respiratory distress syndrome that capture mechanical force-induced injury-inflammation-repair

Hannah Viola; Jonathan Chang; Jocelyn R. Grunwell; Louise Hecker; Rabindra Tirouvanziam; James B. Grotberg; Shuichi Takayama

https://doi.org/10.1063/1.5111549

Editorial

Microphysiological systems

James J. Hickman; Dongeun Huh; Roger D. Kamm

https://doi.org/10.1063/1.5130170

ARTICLES

A human in vitro platform for the evaluation of pharmacology strategies in cardiac ischemia

Carlota Oleaga; Golareh Jalilvand; Gregg Legters; Candace Martin; Gail Ekman; Christopher W. McAleer; Christopher J. Long; James J. Hickman

https://doi.org/10.1063/1.5089237

ARTICLES

Balance of interstitial flow magnitude and vascular endothelial growth factor concentration modulates three-dimensional microvascular network formation

Yoshinori Abe; Masafumi Watanabe; Seok Chung; Roger D. Kamm; Kazuo Tanishita; Ryo Sudo

https://doi.org/10.1063/1.5094735

ARTICLES

Microfluidics-based skin irritation test using in vitro 3D angiogenesis platform

Norhana Jusoh; Jihoon Ko; Noo Li Jeon

https://doi.org/10.1063/1.5093975

ARTICLES

An omentum-inspired 3D PEG hydrogel for identifying ECM-drivers of drug resistant ovarian cancer

Elizabeth A. Brooks; Maria F. Gencoglu; Daniel C. Corbett; Kelly R. Stevens; Shelly R. Peyton

https://doi.org/10.1063/1.5091713

ARTICLES

Scalable microphysiological system to model three-dimensional blood vessels

Mees N. S. de Graaf; Amy Cochrane; Francijna E. van den Hil; Wesley Buijsman; Andries D. van der Meer; Albert van den Berg; Christine L. Mummery; Valeria V. Orlova

https://doi.org/10.1063/1.5090986

REVIEWS