Mechanobiology of the Cell Nucleus
The cell nucleus houses genomic DNA and serves as the cell's central command center. Intriguingly, a rapidly growing body of research suggests that the mechanical properties of the nucleus and physical forces acting on the cell nucleus can directly modulate nuclear function, including gene expression, chromatin organization, and maintenance of genomic integrity. This Special Topic highlights our understanding of "nuclear mechanobiology" as it is increasingly recognized to play important roles in development, tissue homeostasis, and numerous diseases, ranging from muscular dystrophy to heart disease to cancer.
Guest Editors: Jan Lammerding, Adam J. Engler, and Roger Dale Kamm