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Nonlinear Science of Living Systems: From Cellular Mechanisms to Functions

Living systems are complex, inherently nonlinear, and subject to various kinds of interactions with internal and external fluctuations. Articles in this Focus Issue cover many applications of nonlinear science to biological systems and phenomena on different levels and include topics ranging from intracellular communication and single cell dynamics to communication within large, networked populations of biological entities.

Guest Editors: Epaminondas Rosa, Svetlana Postnova, Martin Huber, Alexander Neiman and Sonya Bahar

FOCUS ISSUE: NONLINEAR SCIENCE OF LIVING SYSTEMS: FROM CELLULAR MECHANISMS TO FUNCTIONS

Introduction to Focus Issue: Nonlinear science of living systems: From cellular mechanisms to functions

Epaminondas Rosa; Svetlana Postnova; Martin Huber; Alexander Neiman; Sonya Bahar

10.1063/1.5065367

FOCUS ISSUE: NONLINEAR SCIENCE OF LIVING SYSTEMS: FROM CELLULAR MECHANISMS TO FUNCTIONS

Activity patterns with silent states in a heterogeneous network of gap-junction coupled Huber-Braun model neurons

Aubin Tchaptchet

10.1063/1.5040266

FOCUS ISSUE: NONLINEAR SCIENCE OF LIVING SYSTEMS: FROM CELLULAR MECHANISMS TO FUNCTIONS

Noise-sustained patterns in a model of volume-coupled neural tissue

A. Yu. Verisokin; D. V. Verveyko; E. A. Kuryshovav; D. E. Postnov

10.1063/1.5039854

FOCUS ISSUE: NONLINEAR SCIENCE OF LIVING SYSTEMS: FROM CELLULAR MECHANISMS TO FUNCTIONS

Cooling reverses pathological bifurcations to spontaneous firing caused by mild traumatic injury

B. M. Barlow; B. Joos; A. K. Trinh; A. Longtin

10.1063/1.5040288

FOCUS ISSUE: NONLINEAR SCIENCE OF LIVING SYSTEMS: FROM CELLULAR MECHANISMS TO FUNCTIONS

From mind to molecules and back to mind—Metatheoretical limits and options for systems neuropsychiatry

Felix Tretter

10.1063/1.5040174

FOCUS ISSUE: NONLINEAR SCIENCE OF LIVING SYSTEMS: FROM CELLULAR MECHANISMS TO FUNCTIONS

Global firing rate contrast enhancement in E/I neuronal networks by recurrent synchronized inhibition

Fang Han; Xiaochun Gu; Zhijie Wang; Hong Fan; Jinfeng Cao; Qishao Lu

10.1063/1.5037207

FOCUS ISSUE: NONLINEAR SCIENCE OF LIVING SYSTEMS: FROM CELLULAR MECHANISMS TO FUNCTIONS

Modeling effects of neural fluctuations and inter-scale interactions

Hans Liljenström

10.1063/1.5044510

FOCUS ISSUE: NONLINEAR SCIENCE OF LIVING SYSTEMS: FROM CELLULAR MECHANISMS TO FUNCTIONS

Astrocyte calcium signaling: Interplay between structural and dynamical patterns

A. R. Brazhe; D. E. Postnov; O. Sosnovtseva

10.1063/1.5037153

FOCUS ISSUE: NONLINEAR SCIENCE OF LIVING SYSTEMS: FROM CELLULAR MECHANISMS TO FUNCTIONS

Attractor dynamics of a Boolean model of a brain circuit controlled by multiple parameters

Jérémie Cabessa; Alessandro E. P. Villa

10.1063/1.5042312

FOCUS ISSUE: NONLINEAR SCIENCE OF LIVING SYSTEMS: FROM CELLULAR MECHANISMS TO FUNCTIONS

Describing dynamics of driven multistable oscillators with phase transfer curves

Evgeny Grines; Grigory Osipov; Arkady Pikovsky

10.1063/1.5037290

FOCUS ISSUE: NONLINEAR SCIENCE OF LIVING SYSTEMS: FROM CELLULAR MECHANISMS TO FUNCTIONS

Effects of brain-derived neurotrophic factor and noise on transitions in temporal lobe epilepsy in a hippocampal network

Liyuan Zhang; Denggui Fan; Qingyun Wang; Gerold Baier

10.1063/1.5036690

FOCUS ISSUE: NONLINEAR SCIENCE OF LIVING SYSTEMS: FROM CELLULAR MECHANISMS TO FUNCTIONS

Chaos versus noise as drivers of multistability in neural networks

Patricio Orio; Marilyn Gatica; Rubén Herzog; Jean Paul Maidana; Samy Castro; Kesheng Xu

10.1063/1.5043447

FOCUS ISSUE: NONLINEAR SCIENCE OF LIVING SYSTEMS: FROM CELLULAR MECHANISMS TO FUNCTIONS

Synchronous tonic-to-bursting transitions in a neuronal hub motif

Rosangela Follmann; Annabelle Shaffer; Zachary Mobille; George Rutherford; Epaminondas Rosa

10.1063/1.5039880

FOCUS ISSUE: NONLINEAR SCIENCE OF LIVING SYSTEMS: FROM CELLULAR MECHANISMS TO FUNCTIONS

Front-propagation in bacterial inter-colony communication

Vera Bettenworth; Matthew McIntosh; Anke Becker; Bruno Eckhardt

10.1063/1.5040068

FOCUS ISSUE: NONLINEAR SCIENCE OF LIVING SYSTEMS: FROM CELLULAR MECHANISMS TO FUNCTIONS

Bottom-up approach to torus bifurcation in neuron models

Huiwen Ju; Alexander B. Neiman; Andrey L. Shilnikov

10.1063/1.5042078

FOCUS ISSUE: NONLINEAR SCIENCE OF LIVING SYSTEMS: FROM CELLULAR MECHANISMS TO FUNCTIONS

Is dynamic desaturation better than a static index to quantify the mortality risk in heart failure patients with Cheyne-Stokes respiration?

Philine Granitza; Jan F. Kraemer; Christoph Schoebel; Thomas Penzel; Jürgen Kurths; Niels Wessel

10.1063/1.5039601

FOCUS ISSUE: NONLINEAR SCIENCE OF LIVING SYSTEMS: FROM CELLULAR MECHANISMS TO FUNCTIONS

Recurrence-based information processing in gene regulatory networks

Marçal Gabalda-Sagarra; Lucas B. Carey; Jordi Garcia-Ojalvo

10.1063/1.5039861

FOCUS ISSUE: NONLINEAR SCIENCE OF LIVING SYSTEMS: FROM CELLULAR MECHANISMS TO FUNCTIONS

Spiking patterns and synchronization of thalamic neurons along the sleep-wake cycle

Noah Holmgren Hopkins; Paula Sanz-Leon; Dibyendu Roy; Svetlana Postnova

10.1063/1.5039754

FOCUS ISSUE: NONLINEAR SCIENCE OF LIVING SYSTEMS: FROM CELLULAR MECHANISMS TO FUNCTIONS

Calcium movement in smooth muscle and evaluation of graded functional intercellular coupling

R. Patejdl; T. Noack

10.1063/1.5035168

FOCUS ISSUE: NONLINEAR SCIENCE OF LIVING SYSTEMS: FROM CELLULAR MECHANISMS TO FUNCTIONS

Harnessing stochasticity: How do organisms make choices?

Raymond Noble; Denis Noble

10.1063/1.5039668

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Nonlinear Science of Living Systems: From Cellular Mechanisms to Functions

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Nonlinear Science of Living Systems: From Cellular Mechanisms to Functions

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