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Microfluidics, Circulating Biomarkers and Cancer
Recent advances in cancer research suggest that rich diagnostic and prognostic information can be present in blood-based biomarkers including circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), and exosomes. The field of microfluidics has advanced significantly and is poised to address these challenges, making a significant impact on the development of liquid-biopsy technologies for cancer diagnostics and management. This special issue features research on microfluidic approaches for isolation and detection of cancer-relevant circulating biomarkers.
Guest Editors: Siva Vanapalli and Claire Hur

EDITORIALS
Siva A. Vanapalli; Soojung Clair Hur
REGULAR ARTICLES
Microfluidic device for on-chip isolation and detection of circulating exosomes in blood of breast cancer patients
Available to Purchase
Wenwen Chen; Hongjing Li; Wentao Su; Jianhua Qin
REVIEW ARTICLES
Nanjing Hao; John X. J. Zhang
REGULAR ARTICLES
A microfluidic device for label-free isolation of tumor cell clusters from unprocessed blood samples
Available to Purchase
Nabiollah Kamyabi; Jonathan Huang; Jaewon J. Lee; Vincent Bernard; Alexander Semaan; Bret Stephens; Mark W. Hurd; Siva A. Vanapalli; Anirban Maitra; Paola A. Guerrero
REVIEW ARTICLES
Recent advances in microfluidic methods in cancer liquid biopsy
Available to Purchase
Florina S. Iliescu; Daniel P. Poenar; Fang Yu; Ming Ni; Kiat Hwa Chan; Irina Cima; Hayden K. Taylor; Igor Cima; Ciprian Iliescu
REGULAR ARTICLES
On the transport of particles/cells in high-throughput deterministic lateral displacement devices: Implications for circulating tumor cell separation
Available to Purchase
Arian Aghilinejad; Mohammad Aghaamoo; Xiaolin Chen
REGULAR ARTICLES
On-chip isolation and enrichment of circulating cell-free DNA using microfluidic device
Available to Purchase
Hogyeong Gwak; Junmoo Kim; Sunyeong Cha; Yong–Pil Cheon; Seung-Il Kim; Bongseop Kwak; Kyung-A Hyun; Hyo-Il Jung