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biomarker discovery
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in Quantitative Imaging in Lung Cancer
> Quantitative Imaging in MedicineApplications and Clinical Translation
Published: November 2021
FIG. 8.1 Volumetric CT technique in tissue biomarker discovery. (a) An EGFR mutant NSCLC at baseline, and (b) at 20-day post-therapy. Computer-delineated tumor contours and diameter lines are superimposed on one image from each study date. 3D view of each segmented tumor is displayed at the upper left corner of each panel. A significant change is detected by volume measurement (−52.4%) but not by unidimensional (1D) measurement (−4.4%). (c) AUROCs for the ability of each measurement method to distinguish tumors based on the presence or the absence of a sensitizing mutation. Volumetric (3D) measurement change had better diagnostic accuracy than 1D measurement change ( Zhao et al., 2010 ). More about this image found in Volumetric CT technique in tissue biomarker discovery. (a) An EGFR mutant N...
Book Chapter
Series: AIPP Books, Principles
Published: November 2022
10.1063/9780735424470_001
EISBN: 978-0-7354-2447-0
ISBN: 978-0-7354-2444-9
..., they developed a mathematical model that describes the action potential and its propagation as a function of the lipid membrane capacitance, currents from sodium and potassium voltage-gated ion channels, and current from leak channels. Their discovery earned them the Nobel prize in Physiology and Medicine...
Book Chapter
Series: AIPP Books, Principles
Published: November 2022
10.1063/9780735424470_009
EISBN: 978-0-7354-2447-0
ISBN: 978-0-7354-2444-9
... for a fundamental understanding of biological processes and for developing therapies for human disease. Cell-based assays are a valuable compromise between high throughput molecular interaction studies and low throughput animal experiments, playing an important role in the drug discovery process. Multiple assay...
Book
Series: AIPP Books, Principles
Published: November 2022
10.1063/9780735424470
EISBN: 978-0-7354-2447-0
ISBN: 978-0-7354-2444-9
Book Chapter
Series: AIPP Books, Methods
Published: August 2022
0
EISBN: 978-0-7354-2491-3
ISBN: 978-0-7354-2488-3
... , New York, NY , 2010 ), pp. 995 – 1020 , Chap. 44. Vilar , S. , Cozza , G. , and Moro , S. , “ Medicinal chemistry and the molecular operating environment (MOE): Application of QSAR and molecular docking to drug discovery ,” Curr. Top. Med. Chem. 8 ( 18 ), 1555 – 1572 ( 2008...
Book
Series: AIPP Books, Principles
Published: September 2022
10.1063/9780735424555
EISBN: 978-0-7354-2455-5
ISBN: 978-0-7354-2452-4
Book Chapter
Series: AIPP Books, Methods
Published: August 2022
10.1063/9780735424913_002
EISBN: 978-0-7354-2491-3
ISBN: 978-0-7354-2488-3
.... Krieger ( Elsevier Science , New York, NY , 2010 ), pp. 995 – 1020 , Chap. 44. Vilar , S. , Cozza , G. , and Moro , S. , “ Medicinal chemistry and the molecular operating environment (MOE): Application of QSAR and molecular docking to drug discovery ,” Curr. Top. Med. Chem. 8...
Book
Series: AIPP Books, Methods
Published: September 2022
10.1063/9780735424357
EISBN: 978-0-7354-2435-7
ISBN: 978-0-7354-2432-6
Book
Series: AIPP Books, Methods
Published: August 2022
10.1063/9780735424913
EISBN: 978-0-7354-2491-3
ISBN: 978-0-7354-2488-3
Book Chapter
Series: AIPP Books, Principles
Published: May 2022
0
EISBN: 978-0-7354-2467-8
ISBN: 978-0-7354-2464-7
... vessel vasculitis: Current status and future prospects ,” Autoimmun. Rev. 17 ( 7 ), 715 – 726 ( 2018 ). 10.1016/j.autrev.2018.02.006 Johnson , C. H. , Ivanisevic , J. , and Siuzdak , G. , “ Metabolomics: Beyond biomarkers and towards mechanisms ,” Nat. Rev. Mol. Cell Biol. 17...
Book Chapter
Series: AIPP Books, Principles
Published: May 2022
10.1063/9780735424678_001
EISBN: 978-0-7354-2467-8
ISBN: 978-0-7354-2464-7
... the eye color of Drosophila ( Morgan, 1910 ). These serial discoveries indicate that chromosome in cells is the physical material that carries the heredity substance and genetic information, instructing the representation of traits. The chromosome theory of inheritance, thus, provides...
Book Chapter
Series: AIPP Books, Principles
Published: May 2022
10.1063/9780735424678_009
EISBN: 978-0-7354-2467-8
ISBN: 978-0-7354-2464-7
..., the system can significantly improve the diagnostic accuracy of high-grade squamous intraepithelial lesions. Mapping Genomic Markers, Cytomic Compositions, and Connectomes in the Optically Cleared Tissues Since the discovery of DNA, modern genomics and genetics have made great progress in the past several...
Book Chapter
Series: AIPP Books, Principles
Published: May 2022
10.1063/9780735424678_010
EISBN: 978-0-7354-2467-8
ISBN: 978-0-7354-2464-7
... states. Therefore, oxygen levels can serve as a biomarker of physiological behaviors, metabolic status, and viability. The microelectrode is an invasive method to measure oxygen levels in vivo, despite its perfect accuracy and immediate readout. The insertion of electrodes may cause inflammation...
Book
Series: AIPP Books, Principles
Published: May 2022
10.1063/9780735424678
EISBN: 978-0-7354-2467-8
ISBN: 978-0-7354-2464-7
Book Chapter
Series: AIPP Books, Principles
Published: November 2021
0
EISBN: 978-0-7354-2355-8
ISBN: 978-0-7354-2352-7
...References References Biomarkers Definitions Working Group , “ Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework ,” Clin. Pharmacol. Ther. 69 ( 3 ), 89 – 95 ( 2001 ). 10.1067/mcp.2001.113989 Boone , J. M. , “ Radiological interpretation 2020...
Book Chapter
Series: AIPP Books, Principles
Published: November 2021
10.1063/9780735423558_008
EISBN: 978-0-7354-2355-8
ISBN: 978-0-7354-2352-7
... in tissue biomarker discovery. (a) An EGFR mutant NSCLC at baseline, and (b) at 20-day post-therapy. Computer-delineated tumor contours and diameter lines are superimposed on one image from each study date. 3D view of each segmented tumor is displayed at the upper left corner of each panel. A significant...
Book Chapter
Series: AIPP Books, Principles
Published: November 2021
10.1063/9780735423558_012
EISBN: 978-0-7354-2355-8
ISBN: 978-0-7354-2352-7
... proposed by the Institute of Medicine (IOM) to consist of three basic steps ( Teutsch et al., 2009 ; and Hayes et al., 2013 ): discovery of a biomarker of interest; development of a biomarker test that has analytical validity and clinical or biological validity; evaluation...
Book Chapter
Series: AIPP Books, Principles
Published: September 2021
10.1063/9780735423473_003
EISBN: 978-0-7354-2347-3
ISBN: 978-0-7354-2344-2
...biomarker discovery medical imaging phantoms medical physics non-surgical procedure medical signs electronic medical physics world biological physics Introduction A better understanding of the molecular mechanisms surrounding disease has led to the practice of precision medicine as we know...
Book Chapter
Series: AIPP Books, Perspectives
Published: December 2021
10.1063/9780735423954_006
EISBN: 978-0-7354-2395-4
ISBN: 978-0-7354-2392-3
..., and electrochemical transduction. The use of sensors has increased exponentially in various sectors, sometimes even beyond the periphery of healthcare and diagnosis in activities like study of gene expression, protein–ligand interaction, drug discovery, pharmacophore analysis, drug delivery, forensic tests...
Book Chapter
Series: AIPP Books, Principles
Published: November 2021
0
EISBN: 978-0-7354-2355-8
ISBN: 978-0-7354-2352-7
... ). 10.1118/1.3528204 Arshad , M. A. , “ Discovery of pre-therapy 2-deoxy-2-(18)F-fluoro-D-glucose positron emission tomography-based radiomics classifiers of survival outcome in non-small-cell lung cancer patients ,” Eur. J. Nucl. Med. Mol. Imaging 46 ( 2 ), 455 – 466 ( 2019 ). 10.1007...
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