The demand for new biomaterials in several biomedical applications, such as regenerative engineering and drug delivery, has increased over the past two decades due to emerging technological advances in biomedicine. Degradable polymeric biomaterials continue to play a significant role as scaffolding materials and drug devices. Polyphosphazene platform is a subject of broad interest, as it presents an avenue for attaining versatile polymeric materials with excellent structure and property tunability, and high functional diversity. Macromolecular substitution enables the facile attachment of different organic groups and drug molecules to the polyphosphazene backbone for the development of a broad class of materials. These materials are more biocompatible than traditional biomaterials, mixable with other clinically relevant polymers to obtain new materials and exhibit unique erosion with near-neutral degradation products. Hence, polyphosphazene represents the next generation of biomaterials. In this review, the authors systematically discuss the synthetic design, structure-property relationships, and the promising potentials of polyphosphazenes in regenerative engineering and drug delivery.
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Review Article|
April 09 2020
Polyphosphazene polymers: The next generation of biomaterials for regenerative engineering and therapeutic drug delivery
Kenneth S. Ogueri
;
Kenneth S. Ogueri
1
Department of Materials Science and Engineering, University of Connecticut
, Storrs, Connecticut 062692
Connecticut Convergence Institute for Translation in Regenerative Engineering, University of Connecticut Health Center
, Farmington, Connecticut 06030
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Kennedy S. Ogueri
;
Kennedy S. Ogueri
3
Department of Chemistry, The Pennsylvania State University
, University Park, Pennsylvania 16802
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Harry R. Allcock
;
Harry R. Allcock
3
Department of Chemistry, The Pennsylvania State University
, University Park, Pennsylvania 16802
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Cato T. Laurencin
Cato T. Laurencin
a)
1
Department of Materials Science and Engineering, University of Connecticut
, Storrs, Connecticut 062692
Connecticut Convergence Institute for Translation in Regenerative Engineering, University of Connecticut Health Center
, Farmington, Connecticut 060304
Department of Orthopaedic Surgery, University of Connecticut Health Center
, Farmington, Connecticut 060305
Department of Chemical and Biomolecular Engineering, University of Connecticut
, Storrs, Connecticut 062696
Department of Biomedical Engineering, University of Connecticut
, Storrs, Connecticut 06296
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a)
Electronic mail: [email protected]
Note: This paper is part of the Special Collection of Papers from 10th International Symposium on Clusters and Nanomaterials (ISCAN - 2019).
J. Vac. Sci. Technol. B 38, 030801 (2020)
Article history
Received:
January 30 2020
Accepted:
March 23 2020
Citation
Kenneth S. Ogueri, Kennedy S. Ogueri, Harry R. Allcock, Cato T. Laurencin; Polyphosphazene polymers: The next generation of biomaterials for regenerative engineering and therapeutic drug delivery. J. Vac. Sci. Technol. B 1 May 2020; 38 (3): 030801. https://doi.org/10.1116/6.0000055
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