We present the design and use of an ultrathin, stretchable sensor system capable of conformal lamination onto the skin, for precision measurement and spatial mapping of levels of hydration. This device, which we refer to as a class of ‘epidermal electronics’ due to its ‘skin-like’ construction and mode of intimate integration with the body, contains miniaturized arrays of impedance-measurement electrodes arranged in a differential configuration to compensate for common-mode disturbances. Experimental results obtained with different frequencies and sensor geometries demonstrate excellent precision and accuracy, as benchmarked against conventional, commercial devices. The reversible, non-invasive soft contact of this device with the skin makes its operation appealing for applications ranging from skin care, to athletic monitoring to health/wellness assessment.

1.
C
Blichmann
and
J
Serup
,
Contact Dermat
16
,
155
(
1987
).
2.
M
Boguniewicz
,
N
Nicol
,
K
Kelsay
and
DYM
Leung
,
Semin Cutan Med Surg
27
,
115
(
2008
).
3.
VM
Sharma
,
K
Sridharan
,
G
Pichan
and
MR
Panwar
,
Ergonomics
29
,
791
(
1986
).
5.
S
Verdier-Sévrain
and
F
Bonté
,
J Cosmet Dermatol
6
,
75
(
2007
).
6.
M
Zhang
and
AFT
Mak
,
Prosthet Orthot Int
23
,
135
(
1999
).
7.
Choi JW, Kwon SH, Huh CH, Park KC, Youn SW (2012) Skin Res Technol 0:1–7
8.
L-C
Gerhardt
,
V
Strässle
,
A
Lenz
,
ND
Spencer
and
S
Derler
,
J R Soc Interface
5
,
1317
(
2008
).
9.
T
Frodin
,
P
Helander
,
L
Molin
and
M
Skogh
,
Acta Derm Venereol
68
,
461
(
1988
).
10.
H
Tagami
,
M
Ohi
,
K
Iwatsuki
,
Y
Kanamaru
,
M
Yamada
and
B
Ichijo
,
J Investig Dermatol
75
,
500
(
1980
).
11.
M
Paye
,
D
Gaer
and
BM
Morrison
,
Skin Res Technol
1
,
123
(
1995
).
12.
S
Sasai
,
Y-X
Zhen
and
H
Tagami
,
Skin Res Technol
2
,
173
(
1996
).
13.
P
Xiao
,
LI
Ciortea
,
H
Singh
,
Y
Cui
,
EP
Berg
and
RE
Imhof
,
J Phys: Conf Ser
214
,
012026
(
2010
).
14.
EM
Attas
,
MG
Sowa
,
TB
Posthumus
,
BJ
Schattka
,
HH
Mantsch
and
SL
Zhang
,
Biopolymers
67
,
96
(
2002
).
15.
F
Kadlec
,
M
Berta
,
P
Kužel
,
F
Lopot
and
V
Polakovič
,
Phys Med Biol
53
,
7063
(
2008
).
16.
SI
Alekseev
,
I
Szabo
and
MC
Ziskin
,
Skin Res Technol
14
,
390
(
2008
).
18.
FM
Hendriks
,
D
Brokken
,
CWJ
Oomens
and
FPT
Baaijens
,
Skin Res Technol
10
,
231
(
2004
).
19.
L
Xing
and
SA
Boppart
,
IEEE Trans Biomed Eng
57
,
953
(
2010
).
20.
Hendriks FM (2005) Mechanical behaviour of human epidermal and dermal layers in vivo. Technische Universiteit Eindhoven
21.
G
Tan
,
P
Xu
,
LB
Lawson
,
J
He
,
LC
Freytag
,
JD
Clements
and
VT
John
,
J Pharm Sci
99
,
730
(
2010
).
22.
E
Alanen
,
J
Nuutinen
,
K
Nicklén
,
T
Lahtinen
and
J
Mönkkönen
,
Skin Res Technol
10
,
32
(
2004
).
23.
JW
Fluhr
,
M
Gloor
,
S
Lazzerini
,
P
Kleesz
,
R
Grieshaber
and
E
Berardesca
,
Skin Res Technol
5
,
161
(
1999
).
24.
AO
Barel
and
P
Clarys
,
Skin Res Technol
3
,
107
(
1997
).
25.
P
Clarys
,
AO
Barel
and
B
Gabard
,
Skin Res Technol
5
,
14
(
1999
).
26.
ØG
Martinsen
,
S
Grimnes
and
E
Haug
,
Skin Res Technol
5
,
179
(
1999
).
27.
D-H
Kim
,
N
Lu
,
R
Ma
,
Y-S
Kim
,
R-H
Kim
,
S
Wang
,
J
Wu
,
SM
Won
,
H
Tao
,
A
Islam
,
KJ
Yu
,
R
Chowdhury
,
M
Ying
,
L
Xu
,
M
Li
,
H-J
Chung
,
H
Keum
,
M
McCormick
,
P
Liu
,
Y-W
Zhang
,
FG
Omenetto
,
Y
Huang
,
T
Coleman
and
JA
Rogers
,
Science
333
,
838
(
2011
).
28.
JR
Matthie
,
Expert Rev Med Dev
5
,
239
(
2008
).
29.
A
Guimerà
,
E
Calderón
,
P
Los
and
AM
Christie
,
Physiol Meas
29
,
S279
(
2008
).
30.
T
Yamamoto
and
Y
Yamamoto
,
Med Biol Eng Comput
14
,
151
(
1976
).
31.
C
Gabriel
,
S
Gabriel
and
E
Corthout
,
Phys Med Biol
41
,
2231
(
1996
).
32.
C
Gabriel
,
A
Peyman
and
EH
Grant
,
Phys Med Biol
54
,
4863
(
2009
).
33.
T
Sunaga
,
H
Ikehira
,
S
Furukawa
,
H
Shinkai
,
H
Kobayashi
,
Y
Matsumoto
,
E
Yoshitome
,
T
Obata
,
S
Tanada
,
H
Murata
and
Y
Sasaki
,
Phys Med Biol
47
,
N11
(
2002
).
34.
V
Raicu
,
N
Kitagawa
and
A
Irimajiri
,
Phys Med Biol
45
,
L1
(
2000
).
36.
Hejjel L (2004) Med Sci Monit 10:MT6–MT13
37.
JW
Fluhr
,
M
Gloor
,
S
Lazzerini
,
P
Kleesz
,
R
Grieshaber
and
E
Berardesca
,
Skin Res Technol
5
,
171
(
1999
).
38.
AV
Mamishev
,
K
Sundara-Rajan
,
Y
Fumin
,
D
Yanqing
and
M
Zahn
,
Proc IEEE
92
,
808
(
2004
).
39.
JL
Leveque
and
JD
Rigal
,
J Cosmet Sci
34
,
419
(
1983
).
This content is only available via PDF.