An Mo2C nanosheet is an important two-dimensional nanomaterial with distinguished catalytic activity in biochemical applications. However, detailed information on Mo2C-induced changes in metabolic shifts, biosafety, and molecular mechanisms is insufficient. Integrated metabolomics (including aqueous metabolomics, lipidomics, and spatial metabolomics) has provided an excellent choice with massive bioinformation. In addition, the notion of “nanometabolomics” was first proposed and utilized to refer to these metabolomics studies on the biosafety, biocompatibility, and biological response of nanomaterials. Nanometabolomics innovatively combined nanoscience and metabolomics with massive bioinformation at the molecular level. For instance, in this work, nanometabolomics specialized in probing an Mo2C-induced metabolic shift of human umbilical vein endothelial cells (HUVECs) through integrated metabolomics. Furthermore, integrated metabolomics was used to examine the metabolic shift of HUVECs at the metabolome and lipidome levels, as well as the spatial distribution of different metabolites. The findings demonstrated that high doses (1 mg/ml) of an Mo2C nanosheet might produce an immediate improvement in HUVECs’ energy metabolism, which was closely related to the improved morphology and function of mitochondria. The integrated metabolomics outcomes of this unique “Mo2C-cell” system increased our understanding of an Mo2C nanosheet. The proposed new word “nanometabolomics” could also be considered an excellent notion in representing nanomaterial-involved metabolomics studies.
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November 2024
Research Article|
November 08 2024
Probing the biocompatibility of Mo2C nanosheet through an integrated metabolomics approach: Toward boosting energy metabolism
Dingkun Zhang
;
Dingkun Zhang
(Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Writing – original draft)
1
Department of Pain Management, Anesthesia & Operation Center, Laboratory of Clinical Proteomics and Metabolomics, Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University
, Chengdu 610041, People’s Republic of China
2
NHC Key Laboratory of Transplant Engineering and Immunology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University
, Chengdu 610041, China
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Xin Li;
Xin Li
(Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Writing – original draft)
1
Department of Pain Management, Anesthesia & Operation Center, Laboratory of Clinical Proteomics and Metabolomics, Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University
, Chengdu 610041, People’s Republic of China
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Wen Zheng;
Wen Zheng
(Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Writing – original draft)
1
Department of Pain Management, Anesthesia & Operation Center, Laboratory of Clinical Proteomics and Metabolomics, Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University
, Chengdu 610041, People’s Republic of China
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Luolan Gui;
Luolan Gui
(Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Writing – original draft)
1
Department of Pain Management, Anesthesia & Operation Center, Laboratory of Clinical Proteomics and Metabolomics, Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University
, Chengdu 610041, People’s Republic of China
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Wenjuan Zeng
;
Wenjuan Zeng
(Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Writing – original draft)
1
Department of Pain Management, Anesthesia & Operation Center, Laboratory of Clinical Proteomics and Metabolomics, Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University
, Chengdu 610041, People’s Republic of China
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Yu Zeng;
Yu Zeng
(Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Writing – original draft)
1
Department of Pain Management, Anesthesia & Operation Center, Laboratory of Clinical Proteomics and Metabolomics, Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University
, Chengdu 610041, People’s Republic of China
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Yin Yang;
Yin Yang
(Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Writing – original draft)
3
Department of Clinical Research Management, West China Hospital, Sichuan University
, Chengdu 610041, China
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Rong Fan
;
Rong Fan
(Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Writing – original draft)
4
Department of Mechanical Engineering, City University of Hong Kong
, Kowloon, Hong Kong
and Chengdu Research Institute, City University of Hong Kong
, Chengdu 999077, People’s Republic of China
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Yang Lu
;
Yang Lu
(Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Writing – original draft)
4
Department of Mechanical Engineering, City University of Hong Kong
, Kowloon, Hong Kong
and Chengdu Research Institute, City University of Hong Kong
, Chengdu 999077, People’s Republic of China
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Yueqiu Liu;
Yueqiu Liu
(Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Writing – original draft)
1
Department of Pain Management, Anesthesia & Operation Center, Laboratory of Clinical Proteomics and Metabolomics, Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University
, Chengdu 610041, People’s Republic of China
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Xinyi Hu;
Xinyi Hu
(Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Writing – original draft)
1
Department of Pain Management, Anesthesia & Operation Center, Laboratory of Clinical Proteomics and Metabolomics, Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University
, Chengdu 610041, People’s Republic of China
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Ning Mao;
Ning Mao
(Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Writing – original draft)
5
Institute for Disaster Management and Reconstruction, Sichuan University
, Chengdu 610055, China
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Junwen Guan;
Junwen Guan
(Funding acquisition, Supervision, Validation, Visualization, Writing – review & editing)
6
Department of Neurosurgery, West China Hospital, Sichuan University
, Chengdu 610041, China
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Tao Li
;
Tao Li
(Funding acquisition, Supervision, Validation, Visualization, Writing – review & editing)
7
Laboratory of Mitochondria and Metabolism, Department of Anesthesiology, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University
, Chengdu 610041, China
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Jingqiu Cheng;
Jingqiu Cheng
(Funding acquisition, Supervision, Validation, Visualization, Writing – review & editing)
1
Department of Pain Management, Anesthesia & Operation Center, Laboratory of Clinical Proteomics and Metabolomics, Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University
, Chengdu 610041, People’s Republic of China
2
NHC Key Laboratory of Transplant Engineering and Immunology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University
, Chengdu 610041, China
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Hao Yang
;
Hao Yang
(Funding acquisition, Supervision, Validation, Visualization, Writing – review & editing)
1
Department of Pain Management, Anesthesia & Operation Center, Laboratory of Clinical Proteomics and Metabolomics, Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University
, Chengdu 610041, People’s Republic of China
2
NHC Key Laboratory of Transplant Engineering and Immunology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University
, Chengdu 610041, China
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Meng Gong
Meng Gong
a)
(Funding acquisition, Supervision, Validation, Visualization, Writing – review & editing)
1
Department of Pain Management, Anesthesia & Operation Center, Laboratory of Clinical Proteomics and Metabolomics, Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University
, Chengdu 610041, People’s Republic of China
2
NHC Key Laboratory of Transplant Engineering and Immunology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University
, Chengdu 610041, China
a)Author to whom correspondence should be addressed: [email protected]
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a)Author to whom correspondence should be addressed: [email protected]
Biointerphases 19, 061002 (2024)
Article history
Received:
July 02 2024
Accepted:
October 18 2024
Citation
Dingkun Zhang, Xin Li, Wen Zheng, Luolan Gui, Wenjuan Zeng, Yu Zeng, Yin Yang, Rong Fan, Yang Lu, Yueqiu Liu, Xinyi Hu, Ning Mao, Junwen Guan, Tao Li, Jingqiu Cheng, Hao Yang, Meng Gong; Probing the biocompatibility of Mo2C nanosheet through an integrated metabolomics approach: Toward boosting energy metabolism. Biointerphases 1 November 2024; 19 (6): 061002. https://doi.org/10.1116/6.0003872
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