The present invention describes a novel flexible nanosensor for the electrochemical detection of uric acid (UA) present in urine. The synthesized graphite-boron nanocomposite with an average thickness of ∼32 nm was grown up on a flexible polyvinylidene fluoride film with an average thickness of ∼50 μm and it acts as a nonenzymatic sensor for UA. The developed flexible sensor showed a prominent reduction peak in cyclic voltammetry and amperometric response with the presence of different concentrations of aqueous UA solution. In the electrochemical study, the redox peak was generated near ∼−0.42 V with a detection limit of around ∼2.09 μM as the bottom level. The high robustness of the developed sensor originated from the polymeric film base and the rapid response time of ∼0.5 s for detecting UA present in human urine. The interference property of the sensor was confirmed in the presence of bilirubin and creatinine as an eventual reference toward selectivity. The phase and morphology of the sensor surface were extensively observed before and after sensing to comprehend the electrochemical interaction between the sensor and target molecules. The generated quantitative results of the integrated system were verified by testing known and unknown concentrations of UA solutions.
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July 2023
Research Article|
August 18 2023
Ultraflexible polyvinylidene fluoride film based amperometric enzyme-free sensor for selective detection of uric acid in a trace level
Abhisek Maikap
;
Abhisek Maikap
a)
(Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing)
1
Department of Mechanical Engineering, Indian Institute of Technology Kharagpur
, Kharagpur 721302, India
2
Department of Physics, NIT Durgapur
, Durgapur 713209, India
a)Authors to whom correspondence should be addressed: abhishekmaikap@gmail.com, ajit.meikap@phy.nitdgp.ac.in, and ss2chem@gmail.com
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Riju Karmakar;
Riju Karmakar
(Data curation, Formal analysis, Methodology, Software, Validation, Visualization)
2
Department of Physics, NIT Durgapur
, Durgapur 713209, India
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Ajit Kumar Meikap
;
Ajit Kumar Meikap
a)
(Conceptualization, Formal analysis, Funding acquisition, Investigation, Software, Supervision, Validation, Visualization, Writing – review & editing)
2
Department of Physics, NIT Durgapur
, Durgapur 713209, India
a)Authors to whom correspondence should be addressed: abhishekmaikap@gmail.com, ajit.meikap@phy.nitdgp.ac.in, and ss2chem@gmail.com
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Subhra Samanta
Subhra Samanta
a)
(Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Software, Supervision, Validation, Visualization, Writing – review & editing)
3
MPML Division, CSIR-Central Mechanical Engineering Research Institute
, Durgapur 713209, India
a)Authors to whom correspondence should be addressed: abhishekmaikap@gmail.com, ajit.meikap@phy.nitdgp.ac.in, and ss2chem@gmail.com
Search for other works by this author on:
a)Authors to whom correspondence should be addressed: abhishekmaikap@gmail.com, ajit.meikap@phy.nitdgp.ac.in, and ss2chem@gmail.com
Biointerphases 18, 041003 (2023)
Article history
Received:
April 29 2023
Accepted:
August 02 2023
Citation
Abhisek Maikap, Riju Karmakar, Ajit Kumar Meikap, Subhra Samanta; Ultraflexible polyvinylidene fluoride film based amperometric enzyme-free sensor for selective detection of uric acid in a trace level. Biointerphases 1 July 2023; 18 (4): 041003. https://doi.org/10.1116/6.0002792
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