A smart deoxyribose nucleic acid nanogel coated polydopamine nanosphere hybrid was designed for chemo-photothermal therapy of cancer. The nanohybrid showed good colloid stability, narrow size distribution, high drug loading, good biocompatibility, and high photothermal conversion efficiency, and could release the drug on desired tumor sites.
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See the supplementary material at https://www.scitation.org/doi/suppl/10.1116/6.0002170 for information on the sequence used in the experiment, the UV-vis-NIR absorption spectra of PDA@DNAgel nanohybrids with different concentrations, photographs of the PDA@DNAgel nanohybrids after their dispersion in different solutions for 48 h, temperature elevation of water and PDA@DNAgel nanohybrids with different concentrations as a function of irradiation time, temperature evaluation of the PDA@DNAgel nanohybrids over three NIR laser on/off irradiation cycles, the photothermal response of the PDA@DNAgel nanohybrids (200 μg/ml) with a 808 nm NIR laser irradiation (2 W/cm) for 600 s, the linear time data versus –lnθ, the Vis-NIR absorption spectra of Dox and PDA@DNAgel in aqueous solution, the Dox loading efficiency at different Dox: PDA@DNAgel NPs ratios, and the in vitro drug-release profiles of PDA@DNAgel-Dox NPs in media with different pH values, and with and without NIR laser irradiations, respectively.
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