Magnetic nanoparticle (MNP) induced magnetic hyperthermia has been demonstrated as a promising technique for the treatment of brain tumor. However, lower heating efficiency resulting from low intratumoral accumulation of magnetic nanomaterials is still one of the significant limitations for their thermotherapeutic efficacy. In this study, we have designed a nanobubble structure with MNPs decorated on the shell, which leads to the improvement of magnetocaloric performance under an alternating magnetic field. First, the phospholipid coupled with MNPs as the shell to be self-assembled magnetic nanobubbles (MNBs) was fabricated by a temperature-regulated repeated compression self-assembly approach. Then, the optimal magnetic heating concentration, electric current parameters for producing the magnetic field, and the number of magnetic heating times were investigated for tuning the better magnetoenergy conversion. Finally, the well-defined geometrical orientation of MNPs on the nanobubble structure enhanced hypothermia effect was investigated. The results demonstrate that the MNBs could promote the endocytosis of magnetic nanoparticles by glioma cells, resulting in better therapeutic effect. Therefore, the controlled assembly of MNPs into well-defined bubble structures could serve as a new hyperthermia agent for tumor therapy.
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Fine-tuned magnetic nanobubbles for magnetic hyperthermia treatment of glioma cells
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November 2022
Research Article|
November 11 2022
Fine-tuned magnetic nanobubbles for magnetic hyperthermia treatment of glioma cells

Special Collection:
Special Topic Collection: Biointerface Science in China
Bin Li;
Bin Li
(Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing)
1
State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Sciences and Medical Engineering, Southeast University
, Nanjing 210096, China
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Yuexia Han;
Yuexia Han
(Data curation, Investigation, Methodology, Writing – original draft, Writing – review & editing)
2
Technology and Engineering Center for Space Utilization, Chinese Academy of Sciences
, Beijing 100094, China
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Yang Liu;
Yang Liu
(Investigation, Methodology)
1
State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Sciences and Medical Engineering, Southeast University
, Nanjing 210096, China
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Fang Yang
Fang Yang
a)
(Conceptualization, Funding acquisition, Investigation, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing)
1
State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Sciences and Medical Engineering, Southeast University
, Nanjing 210096, China
a)Author to whom correspondence should be addressed: [email protected]
Search for other works by this author on:
1
State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Sciences and Medical Engineering, Southeast University
, Nanjing 210096, China
2
Technology and Engineering Center for Space Utilization, Chinese Academy of Sciences
, Beijing 100094, China
a)Author to whom correspondence should be addressed: [email protected]
Note: This paper is part of the Biointerphases Special Topic Collection on Biointerface Science in China.
Biointerphases 17, 061004 (2022)
Article history
Received:
July 27 2022
Accepted:
October 21 2022
Citation
Bin Li, Yuexia Han, Yang Liu, Fang Yang; Fine-tuned magnetic nanobubbles for magnetic hyperthermia treatment of glioma cells. Biointerphases 1 November 2022; 17 (6): 061004. https://doi.org/10.1116/6.0002110
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