We present the conducting polymer poly (3,4-ethylenedioxythiophene) (PEDOT) doped with an algal-derived glycan extract, Phycotrix™ [xylorhamno-uronic glycan (XRU84)], as an innovative electrically conductive material capable of providing beneficial biological and electrical cues for the promotion of favorable wound healing processes. Increased loading of the algal XRU84 into PEDOT resulted in a reduced surface nanoroughness and interfacial surface area and an increased static water contact angle. PEDOT-XRU84 films demonstrated good electrical stability and charge storage capacity and a reduced impedance relative to the control gold electrode. A quartz crystal microbalance with dissipation monitoring study of protein adsorption (transferrin, fibrinogen, and collagen) showed that collagen adsorption increased significantly with increased XRU84 loading, while transferrin adsorption was significantly reduced. The viscoelastic properties of adsorbed protein, characterized using the ΔD/Δf ratio, showed that for transferrin and fibrinogen, a rigid, dehydrated layer was formed at low XRU84 loadings. Cell studies using human dermal fibroblasts demonstrated excellent cell viability, with fluorescent staining of the cell cytoskeleton illustrating all polymers to present excellent cell adhesion and spreading after 24 h.
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March 2021
Research Article|
March 22 2021
Fibrinogen, collagen, and transferrin adsorption to poly(3,4-ethylenedioxythiophene)-xylorhamno-uronic glycan composite conducting polymer biomaterials for wound healing applications
Paul J. Molino
;
Paul J. Molino
a)
1
ARC Centre of Excellence for Electromaterials Science (ACES), Intelligent Polymer Research Institute, University of Wollongong
, Wollongong, Australia
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John Will;
John Will
2
Department of Bioengineering, The University of Texas at Dallas
, Richardson, Texas 75080, USA
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Luciana Yumiko Daikuara;
Luciana Yumiko Daikuara
1
ARC Centre of Excellence for Electromaterials Science (ACES), Intelligent Polymer Research Institute, University of Wollongong
, Wollongong, Australia
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Alexander R. Harris
;
Alexander R. Harris
3
ARC Centre of Excellence for Electromaterials Science (ACES), Department of Medicine, Dentistry and Health Sciences, University of Melbourne
, Melbourne, Australia
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Zhilian Yue;
Zhilian Yue
1
ARC Centre of Excellence for Electromaterials Science (ACES), Intelligent Polymer Research Institute, University of Wollongong
, Wollongong, Australia
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Jeremy Dinoro;
Jeremy Dinoro
1
ARC Centre of Excellence for Electromaterials Science (ACES), Intelligent Polymer Research Institute, University of Wollongong
, Wollongong, Australia
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Pia Winberg
;
Pia Winberg
4
Venus Shell Systems Pty. Ltd
, 1 Scallop St, Huskisson, Australia and School of Medicine, University of Wollongong, Wollongong, Australia
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Gordon G. Wallace
Gordon G. Wallace
b)
1
ARC Centre of Excellence for Electromaterials Science (ACES), Intelligent Polymer Research Institute, University of Wollongong
, Wollongong, Australia
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a)
Electronic mail: pmolino@uow.edu.au
b)
Electronic mail: gwallace@uow.edu.au
Note: This paper is part of the Special Topic Collection on Quartz Crystal Microbalance in Biological Surface Science and Soft Matter.
Biointerphases 16, 021003 (2021)
Article history
Received:
October 11 2020
Accepted:
February 25 2021
Citation
Paul J. Molino, John Will, Luciana Yumiko Daikuara, Alexander R. Harris, Zhilian Yue, Jeremy Dinoro, Pia Winberg, Gordon G. Wallace; Fibrinogen, collagen, and transferrin adsorption to poly(3,4-ethylenedioxythiophene)-xylorhamno-uronic glycan composite conducting polymer biomaterials for wound healing applications. Biointerphases 1 March 2021; 16 (2): 021003. https://doi.org/10.1116/6.0000708
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