Surface modification of biomaterials is a strategy used to improve cellular and in vivo outcomes. However, most studies do not evaluate the lifetime of the introduced surface layer, which is an important aspect affecting how a biomaterial will interact with a cellular environment both in the short and in the long term. This study evaluated the surface layer stability in vitro in buffer solution of materials produced from poly(lactic-co-glycolic acid) (50:50) and polycaprolactone modified by hydrolysis and/or grafting of hydrophilic polymers using grafting from approaches. The data presented in this study highlight the shortcomings of using model substrates (e.g., spun-coated films) rather than disks, particles, and scaffolds. It also illustrates how similar surface modification strategies in some cases result in very different lifetimes of the surface layer, thus emphasizing the need for these studies as analogies cannot always be drawn.
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November 2020
Research Article|
December 04 2020
Evaluation of surface layer stability of surface-modified polyester biomaterials
Hamish Poli
;
Hamish Poli
1
School of Chemistry and Molecular Biosciences, The University of Queensland
, St Lucia 4072, Australia
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Alexandra L. Mutch
;
Alexandra L. Mutch
1
School of Chemistry and Molecular Biosciences, The University of Queensland
, St Lucia 4072, Australia
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Anitha A
;
Anitha A
1
School of Chemistry and Molecular Biosciences, The University of Queensland
, St Lucia 4072, Australia
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Saso Ivanovski
;
Saso Ivanovski
2
School of Dentistry, The University of Queensland
, Herston 4006, Australia
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Cedryck Vaquette
;
Cedryck Vaquette
2
School of Dentistry, The University of Queensland
, Herston 4006, Australia
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David G. Castner;
David G. Castner
3
Department of Bioengineering and Department of Chemical Engineering, National ESCA and Surface Analysis Center for Biomedical Problems, University of Washington
, Seattle, Washington 98195
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María Natividad Gómez-Cerezo
;
María Natividad Gómez-Cerezo
a)
2
School of Dentistry, The University of Queensland
, Herston 4006, Australia
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Lisbeth Grøndahl
Lisbeth Grøndahl
b)
1
School of Chemistry and Molecular Biosciences, The University of Queensland
, St Lucia 4072, Australia
4
The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland
, St Lucia 4072, Australia
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a)
Electronic mail: m.gomezcerezo@uq.edu.au
b)
Electronic mail: l.grondahl@uq.edu.au
Note: This paper is part of the Biointerphases Special Topic Collection on Biointerface Science in Australia 2020 - An issue in celebration of Hans Griesser's career.
Biointerphases 15, 061010 (2020)
Article history
Received:
October 01 2020
Accepted:
November 05 2020
Citation
Hamish Poli, Alexandra L. Mutch, Anitha A, Saso Ivanovski, Cedryck Vaquette, David G. Castner, María Natividad Gómez-Cerezo, Lisbeth Grøndahl; Evaluation of surface layer stability of surface-modified polyester biomaterials. Biointerphases 1 November 2020; 15 (6): 061010. https://doi.org/10.1116/6.0000687
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