Surface modification of biomaterials is a strategy used to improve cellular and in vivo outcomes. However, most studies do not evaluate the lifetime of the introduced surface layer, which is an important aspect affecting how a biomaterial will interact with a cellular environment both in the short and in the long term. This study evaluated the surface layer stability in vitro in buffer solution of materials produced from poly(lactic-co-glycolic acid) (50:50) and polycaprolactone modified by hydrolysis and/or grafting of hydrophilic polymers using grafting from approaches. The data presented in this study highlight the shortcomings of using model substrates (e.g., spun-coated films) rather than disks, particles, and scaffolds. It also illustrates how similar surface modification strategies in some cases result in very different lifetimes of the surface layer, thus emphasizing the need for these studies as analogies cannot always be drawn.
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See supplementary material at http://dx.doi.org/10.1116/6.0000687 for DLS intensity based particle size distributions (Figure S1 and S2); AFM data for thickness estimation of PLGA film (Figure S3); XPS data of PLGA film (Figure S4); PCL film and disk AFM and SEM data (Figure S5); XPS of grafted PCL films and disks (Figure S6); XPS data of PCL scaffold samples (Figure S7); SEM data of PCL scaffold samples (Figure S8).
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