Functional surface coatings are a key option for biomedical applications, from polymeric supports for tissue engineering to smart matrices for controlled drug delivery. Therefore, the synthesis of new materials for biological applications and developments is promising. Hence, biocompatible and stimuli-responsive polymers are interesting materials, especially when they present conductive properties. PEDOT-co-PDLLA graft copolymer exhibits physicochemical and mechanical characteristics required for biomedical purposes, associated with electroactive, biocompatible, and partially biodegradable properties. Herein, the study of fibronectin (FN) adsorption onto PEDOT-co-PDLLA carried out by an electrochemical quartz crystal microbalance with dissipation is reported. The amount of FN adsorbed onto PEDOT-co-PDLLA was higher than that adsorbed onto the Au surface, with a significant increase when electrical stimulation was applied (either at +0.5 or −0.125 V). Additionally, FN binds to the copolymer interface in an unfolded conformation, which can promote better NIH-3T3 fibroblast cell adhesion and later cell development.
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Electrochemical quartz crystal microbalance with dissipation investigation of fibronectin adsorption dynamics driven by electrical stimulation onto a conducting and partially biodegradable copolymer
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March 2020
Research Article|
March 20 2020
Electrochemical quartz crystal microbalance with dissipation investigation of fibronectin adsorption dynamics driven by electrical stimulation onto a conducting and partially biodegradable copolymer

Aruã C. da Silva;
Aruã C. da Silva
1
Departamento de Química Fundamental, Instituto de Química, Universidade de São Paulo
, Av. Prof. Lineu Prestes, 748, CP 26077, 05508-000 São Paulo, Brazil
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Rubens A. da Silva;
Rubens A. da Silva
1
Departamento de Química Fundamental, Instituto de Química, Universidade de São Paulo
, Av. Prof. Lineu Prestes, 748, CP 26077, 05508-000 São Paulo, Brazil
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Maria J. P. G. Souza;
Maria J. P. G. Souza
1
Departamento de Química Fundamental, Instituto de Química, Universidade de São Paulo
, Av. Prof. Lineu Prestes, 748, CP 26077, 05508-000 São Paulo, Brazil
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Paula M. Montoya;
Paula M. Montoya
2
Centro de Investigación, Innovación y Desarrollo de Materiales—CIDEMAT, Universidad de Antioquia UdeA
, Calle 70 No. 52-21, Medellín Apartado Aéreo 1226, Colombia
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Ricardo Bentini;
Ricardo Bentini
1
Departamento de Química Fundamental, Instituto de Química, Universidade de São Paulo
, Av. Prof. Lineu Prestes, 748, CP 26077, 05508-000 São Paulo, Brazil
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Tatiana Augusto;
Tatiana Augusto
1
Departamento de Química Fundamental, Instituto de Química, Universidade de São Paulo
, Av. Prof. Lineu Prestes, 748, CP 26077, 05508-000 São Paulo, Brazil
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Roberto M. Torresi
;
Roberto M. Torresi
1
Departamento de Química Fundamental, Instituto de Química, Universidade de São Paulo
, Av. Prof. Lineu Prestes, 748, CP 26077, 05508-000 São Paulo, Brazil
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Luiz H. Catalani;
Luiz H. Catalani
1
Departamento de Química Fundamental, Instituto de Química, Universidade de São Paulo
, Av. Prof. Lineu Prestes, 748, CP 26077, 05508-000 São Paulo, Brazil
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Susana I. Córdoba de Torresi
Susana I. Córdoba de Torresi
a)
1
Departamento de Química Fundamental, Instituto de Química, Universidade de São Paulo
, Av. Prof. Lineu Prestes, 748, CP 26077, 05508-000 São Paulo, Brazil
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a)
Electronic mail: [email protected]
Note: This paper is part of the Special Topic Collection on Quartz Crystal Microbalance in Biological Surface Science and Soft Matter.
Biointerphases 15, 021003 (2020)
Article history
Received:
January 13 2020
Accepted:
February 21 2020
Connected Content
A companion article has been published:
Electrical stimulation affects adsorption dynamics in a conductive, biocompatible polymer
Citation
Aruã C. da Silva, Rubens A. da Silva, Maria J. P. G. Souza, Paula M. Montoya, Ricardo Bentini, Tatiana Augusto, Roberto M. Torresi, Luiz H. Catalani, Susana I. Córdoba de Torresi; Electrochemical quartz crystal microbalance with dissipation investigation of fibronectin adsorption dynamics driven by electrical stimulation onto a conducting and partially biodegradable copolymer. Biointerphases 1 March 2020; 15 (2): 021003. https://doi.org/10.1116/1.5144983
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