A study of the transdermal delivery of Cyclosporine A by atmospheric plasma irradiation was realized on the epidermal layer of the Hairless Yucatan micropig. Drug flux and the amount of drug penetrated through the skin were determined by a Franz cell diffusion experiment. After treatment of the skin by atmospheric plasma jet or microplasma dielectric barrier discharge, an increase in the permeability of the skin was observed. The authors did not observe drug penetration for samples that were not treated with plasma. There was no significant difference between treatments of skin by plasma jet or microplasma dielectric barrier discharge. Drug flux increased to its maximal value up to 3 h after the drug application, and then it decreased. This phenomenon could indicate a temporal effect of plasma on skin. A pharmacokinetic two-compartment model was developed to estimate the possibility of using plasma drug delivery of Cyclosporine A in medical praxis. Our model showed that it is possible to use this technique if a suitable treatment area and concentration of applied drug are chosen.

1.
F. L.
Lopez
,
T. B.
Ernest
,
C.
Tuleu
, and
M. O.
Gul
,
Expert Opin. Drug Delivery
12
,
1727
(
2015
).
2.
N.
Spomer
,
V.
Klingmann
,
I.
Stoltenberg
,
C.
Lerch
,
T.
Meissner
, and
J.
Breitkreutz
,
Arch. Dis. Child.
97
,
283
(
2012
).
3.
J. H.
Lin
,
M.
Chiba
, and
T. A.
Baille
,
Pharmacolog. Rev.
51
,
135
(
1999
).
4.
D.
Josephson
, “
Patient preparation and site selection for peripheral IV infusion therapy
,” in
Intravenous Infusion Therapy for Nurses: Principles and Practice
, 2nd ed. (
Thomson Delmare Learning
,
New York
,
2004
).
5.
K. L.
Stoner
,
H.
Harder
,
L. J.
Fallowfield
, and
V. A.
Jemkins
,
Patient
8
,
145
(
2015
).
7.
B. W.
Barry
,
J. Controlled Release
6
,
85
(
1987
).
8.
A. K.
Levang
,
K.
Zhao
, and
J.
Singh
,
Int. J. Pharm.
181
,
255
(
1999
).
9.
T. M.
Suhonen
,
J. A.
Bouwstra
, and
A.
Urtti
,
J. Controlled Release
59
,
149
(
1999
).
10.
N. G.
Turner
,
L.
Ferry
,
M.
Price
,
Ch.
Cullander
, and
R. H.
Guy
,
Pharm. Res.
14
,
1322
(
1997
).
11.
C.
Lombry
,
N.
Dujardin
, and
V.
Preat
,
Pharm. Res.
17
,
32
(
2000
).
12.
E.
Krueger
,
J. L. C.
Junior
,
E. M.
Scheeren
,
E. B.
Neves
,
E.
Mulinari
, and
P.
Nohama
,
Fisioter. Mov.
27
,
469
(
2014
).
13.
M. R.
Prausnitz
and
R.
Langer
,
Nat. Biotechnol.
26
,
1261
(
2008
).
14.
K.
Shimizu
,
An. N.
Tran
, and
M.
Blajan
,
Jpn. J. App. Phys., Part 1
55
,
07LG01
(
2016
).
15.
S.
Kalghatgi
,
C.
Tsai
,
R.
Gray
, and
D.
Pappas
,
22nd International Symposium on Plasma Chemistry
, Antwerp, Belgium, 5–10 July (
2015
), p.
O-22-6
.
16.
K.
Shimizu
,
K.
Hayashida
, and
M.
Blajan
,
Biointerphases
10
,
029517
(
2015
).
17.
E. J.
Szili
,
J. W.
Bradley
, and
R. D.
Short
,
J. Phys. D: Appl. Phys.
47
,
152002
(
2014
).
18.
K.
Kartaschew
,
M.
Mischo
,
S.
Baldus
,
E.
Bründermann
,
P.
Awakowicz
, and
M.
Havenith
,
Biointerphases
10
,
029516
(
2015
).
19.
M.
Marschewski
,
J.
Hirschberg
,
T.
Omairi
,
W.
Viol
,
S.
Emmert
, and
W.
Maus-Friedrichs
,
Exp. Dermatol.
21
,
921
(
2012
).
20.
J.
Van der Paal
,
S.
Aernouts
,
A. C. T.
van Duin
,
E. C.
Neyts
, and
A.
Bogaerts
,
J. Phys. D: Appl. Phys.
46
,
395201
(
2013
).
21.
J.
Van der Paal
,
C. C.
Verlackt
,
M.
Yusupov
,
E. C.
Neyts
, and
A.
Bogaerts
,
J. Phys. D: Appl. Phys.
48
,
155202
(
2015
).
22.
R.
Tero
,
Y.
Suda
,
R.
Kato
,
H.
Tanoue
, and
H.
Takikawa
,
Appl. Phys. Express.
7
,
077001
(
2014
).
23.
Y.
Suda
,
R.
Tero
,
R.
Yamashita
,
K.
Yusa
, and
H.
Takikawa
,
Jpn. J. Appl. Phys., Part 1
55
,
03DF05
(
2016
).
24.
K.
Shimizu
,
A. N.
Tran
,
J.
Kristof
, and
M.
Blajan
,
Proceedings of the 2016 Electrostatics Joint Conference
, Lafayette, 13–18 June (
2016
), p.
I4
.
25.
J.
Kristof
,
A. N.
Tran
,
M. G.
Blajan
, and
K.
Shimizu
,
Adv. Intell. Syst. Comput.
519
,
167
(
2016
).
26.
K.
Shimizu
,
N. A.
Tran
,
K.
Hayashida
, and
M.
Blajan
,
J. Phys. D: Appl. Phys.
49
,
315201
(
2016
).
27.
B. D.
Kahan
,
New Engl. J. Med.
321
,
1725
(
1989
).
28.
J. D.
Bos
and
M. M.
Meinardi
,
Exp. Dermatol.
9
,
165
(
2000
).
29.
L. B.
Lopes
,
J. H.
Collett
, and
M. V. L. B.
Bentley
,
Eur. J. Pharma. Biopharma.
60
,
25
(
2005
).
30.
J.
Guo
,
Q.
Ping
,
G.
Sun
, and
C.
Jiao
, Int. J. Pharm.
194
,
201
(
2000
).
31.
H. K.
Choi
,
G. L.
Fflynn
, and
G. L.
Amidon
,
J. Pharm. Sci.
84
,
581
(
1995
).
32.
N. P.
Chau
,
J. Pharmacokinet. Biopharm.
5
,
391
(
1977
).
33.
34.
R. A.
Ronfeld
and
L. Z.
Benet
,
J. Pharm. Sci.
66
,
178
(
1977
).
35.
G. F.
Cooney
,
K.
Habucky
, and
K.
Hoppu
,
Clin. Pharmacokinet.
32
,
481
(
1997
).
36.
S. C. L. M.
Cremers
,
E. M.
Scholten
,
R. C.
Schoemaker
,
E. G. W. M.
Lentjes
,
P.
Vermeij
,
L. C.
Paul
,
J.
den Hartigh
, and
J. W.
de Fijter
,
Nephrol., Dial., Transplant.
18
,
1201
(
2003
).
37.
A. J.
Willemze
,
S. C.
Cremers
,
R. C.
Schoemaker
,
A. C.
Lankester
,
J.
Den Hartigh
,
J.
Burggraaf
, and
J. M.
Vossen
,
Br. J. Clin. Pharmacol.
66
,
539
(
2008
).
38.
L. A.
Bauer
,
Applied Clinical Pharmacokinetics
(
McGraw-Hill Professional
,
New York and Columbus, OH
,
2008
).
39.
D.-P.
Wang
,
Ch.-Y.
Lin
,
D.-L.
Chu
, and
L.-Ch.
Chang
,
Drug Dev. Ind. Pharm.
23
,
99
(
1997
).
40.
H.
Pinkus
,
J. Invest. Dermatol.
16
,
383
(
1951
).
41.
S.
Wang
,
M.
Kara
, and
T. R.
Krishnan
,
J. Controlled Release
50
,
61
(
1998
).
42.
H.
Liu
,
S.
Li
,
W.
Pan
,
Y.
Wang
,
F.
Han
, and
H.
Yao
,
Int. J. Pharm.
326
,
32
(
2006
).
43.
H.
Liu
,
S.
Li
,
Y.
Wang
,
H.
Yao
, and
Y.
Zhang
, Int. J. Pharm.
311
,
182
(
2006
).
44.
H.
Liu
,
Y.
Wang
,
F.
Han
,
H.
Yao
, and
S.
Li
,
J. Pharm. Sci.
96
,
3000
(
2007
).
45.
B.
Steffansen
,
B.
Brodin
, and
C. U.
Nielsen
, “
Passive diffusion of drug substances: The concepts of flux and permeability
,” in
Molecular Biopharmaceutics
(
Pharmaceutical
,
London
,
2009
).
46.
A. P.
Raphael
,
S. C.
Meliga
,
X.
Chen
,
G. J. P.
Fernando
,
Ch.
Flaim
, and
M. A. F.
Kendallet
,
J. Controlled Release
166
,
87
(
2013
).
47.
A. Z.
Alkilani
,
M. T. C.
McCrudden
, and
R. F.
Donnelly
,
Pharmaceutics
7
,
438
(
2015
).
48.
H.
Takruri
, U.S. patent 20150352176 A1 (10 December
2015
).
49.
P.
Augustijns
and
M.
Brewster
,
Solvent Systems: Their Selection in Pharmaceutics and Biopharmaceutics
(
Springer Science & Business Media
,
New York
,
2007
).
50.
Y.
Ran
,
L.
Zhao
,
Q.
Xu
, and
S. H.
Yalkowsky
,
AAPS PharmSciTech
2
,
23
(
2001
).
51.
H.
Tanojo
,
J. A.
Bouwstra
,
H. E.
Junginger
, and
H. E.
Bodde
,
J. Therm. Anal. Calorim.
57
,
313
(
1999
).
52.
S. J.
Jiang
,
Y. K.
Kim
, and
S. H.
Lee
,
Ann. Dermatol.
10
,
153
(
1998
).
53.
K. K.
Petersen
,
M. L.
Rousing
,
C.
Jensen
,
L.
Arendt-Nielsen
, and
P.
Gazerani
,
Int. J. Physiol. Pathophysiol. Pharmacol.
3
,
236
(
2011
).
54.
D. G.
Wood
,
M. B.
Brown
, and
S. A.
Jones
,
Eur. J. Pharm. Biopharm.
81
,
642
(
2012
).
55.
A. R.
Ragab
,
M. K.
Al-Mazroua
, and
S.
Abd-Elziz Al-Dakrory
,
J. Clin. Toxicol.
3
,
154
(
2013
).
56.
M. N.
Pastore
,
Y. N.
Kalia
,
M.
Horstmann
, and
M. S.
Roberts
,
Br. J. Pharmacol.
172
,
2179
(
2015
).
58.
B.
Al-Qallaf
,
D.
Mori
,
L.
Olatunji
,
D. B.
Das
, and
Z.
Cui
,
Int. J. Chem. React. Eng.
7
,
1
(
2009
).
59.
A. E. M.
Vickers
,
W. A.
Biggi
,
R.
Dannecker
, and
V.
Fischer
,
Life Sci.
57
,
215
(
1995
).
60.
A. M.
Romgens
,
D. L.
Bader
,
J. A.
Bouwstra
,
F. P. T.
Baaijens
, and
C. W. J.
Oomens
,
J. Mech. Behav. Biomed. Mater.
50
,
215
(
2015
).
61.
B.
Koch
,
I.
Rubino
,
F.-S.
Quan
,
B.
Yoo
, and
H.-J.
Choi
,
Materials
9
,
646
(
2016
).
62.
D.
Carvalho
,
S.
Ghosh
,
R.
Banerjee
, and
P.
Ayyub
,
Nanotechnology
19
,
445713
(
2008
).
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