Our goal is an office-based, handheld ultrasound system to target, detach, break, and/or expel stones and stone fragments from the urinary collecting system to facilitate natural clearance. Repositioning of stones in humans (maximum 2.5 MPa, and 3-second bursts) and breaking of stones in a porcine model (maximum 50 cycles, 20 Hz repetition, 30 minutes, and 7 MPa peak negative pressure) have been demonstrated using the same 350-kHz probe. Repositioning in humans was conducted during surgery with a ureteroscope in the kidney to film stone movement. Independent video review confirmed stone movements (≥ 3 mm) in 15 of 16 kidneys (94%). No serious or unanticipated adverse events were reported. Experiments of burst wave lithotripsy (BWL) effectiveness on breaking human stones implanted in the porcine bladder and kidney demonstrated fragmentation of 7 of 7 stones on post mortem dissection. A 1-week survival study with the BWL exposures and 10 specific pathogen-free pigs, showed all findings were within normal limits on clinical pathology, hematology, and urinalysis. These results demonstrate that repositioning of stones with ultrasonic propulsion and breaking of stones with BWL are safe and effective.
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5 November 2018
176th Meeting of Acoustical Society of America 2018 Acoustics Week in Canada
5–9 Nov 2018
Victoria, Canada
Biomedical Acoustics: Paper 2pBAa1
December 21 2018
Update on clinical trials of kidney stone repositioning and preclinical results of stone breaking with one system
Michael R. Bailey;
Michael R. Bailey
1Center for Industrial and Medical Ultrasound, Applied Physics Laboratory,
University of Washington
, Seattle, WA, 98105, USA
; bailey@apl.washington.edu
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Yak-Nam Wang;
Yak-Nam Wang
2Applied Physics Laboratory, Center for Industrial and Medical Ultrasound,
University of Washington
, Seattle, WA, 98105, USA
; ynwang@uw.edu; wkreider@uw.edu, bwc@uw.edu, mrbean@uw.edu
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Wayne Kreider;
Wayne Kreider
2Applied Physics Laboratory, Center for Industrial and Medical Ultrasound,
University of Washington
, Seattle, WA, 98105, USA
; ynwang@uw.edu; wkreider@uw.edu, bwc@uw.edu, mrbean@uw.edu
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Jessica C. Dai;
Jessica C. Dai
3Department of Urology,
University of Washington School of Medicine
, Seattle, WA, 98195, USA
; jcdai@uw.edu, jdharper@uw.edu, helenachang@gmail.com, amax38@uw.edu
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Bryan W. Cunitz;
Bryan W. Cunitz
2Applied Physics Laboratory, Center for Industrial and Medical Ultrasound,
University of Washington
, Seattle, WA, 98105, USA
; ynwang@uw.edu; wkreider@uw.edu, bwc@uw.edu, mrbean@uw.edu
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Jonathan D. Harper;
Jonathan D. Harper
3Department of Urology,
University of Washington School of Medicine
, Seattle, WA, 98195, USA
; jcdai@uw.edu, jdharper@uw.edu, helenachang@gmail.com, amax38@uw.edu
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Helena Chang;
Helena Chang
3Department of Urology,
University of Washington School of Medicine
, Seattle, WA, 98195, USA
; jcdai@uw.edu, jdharper@uw.edu, helenachang@gmail.com, amax38@uw.edu
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Mathew D. Sorensen;
Mathew D. Sorensen
4Division of Urology,
Department of Veteran Affairs Medical Center
, Seattle, WA, 98108, USA
; mathews@uw.edu
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Ziyue Liu;
Ziyue Liu
5Department of Biostatistics,
Indiana University-Purdue University
, Indianapolis, IN, 46202, USA
; ziliu@iu.edu
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Barbrina Dunmire;
Barbrina Dunmire
2Applied Physics Laboratory, Center for Industrial and Medical Ultrasound,
University of Washington
, Seattle, WA, 98105, USA
; ynwang@uw.edu; wkreider@uw.edu, bwc@uw.edu, mrbean@uw.edu
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Adam D. Maxwell
Adam D. Maxwell
3Department of Urology,
University of Washington School of Medicine
, Seattle, WA, 98195, USA
; jcdai@uw.edu, jdharper@uw.edu, helenachang@gmail.com, amax38@uw.edu
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Proc. Mtgs. Acoust. 35, 020004 (2018)
Article history
Received:
December 11 2018
Accepted:
December 16 2018
Connected Content
Citation
Michael R. Bailey, Yak-Nam Wang, Wayne Kreider, Jessica C. Dai, Bryan W. Cunitz, Jonathan D. Harper, Helena Chang, Mathew D. Sorensen, Ziyue Liu, Oren Levy, Barbrina Dunmire, Adam D. Maxwell; Update on clinical trials of kidney stone repositioning and preclinical results of stone breaking with one system. Proc. Mtgs. Acoust. 5 November 2018; 35 (1): 020004. https://doi.org/10.1121/2.0000949
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