Radiological clips are commonly used to track and identify lesions in breast cancer patients receiving neoadjuvant chemotherapy. Available radiological clips often suffer degradation of visibility in ultrasound during the course of treatment, thus requiring more involved localization procedures to identify regions prior to resection. Furthermore, upon localization, additional markers are placed to aid surgeons during resection. We describe a biocompatible electronic device which transmits a unique identification signal when imaged with ultrasound pulse inversion,i.e., ultrasound identification (USID). The USID clip provides better localization and visualization of the clip compared to passive clips. Furthermore, the ultrasound systems can be programmed to produce an audible indicator of a specific clip’s presence and proximity to the probe, thereby eliminating the need for insertion of additional markers. This concept is tested using a microcontroller and a direct digital synthesis board connected to two sonomicrocrystals, a Verasonics research system, and tissue mimicking phantoms. Clips with six different USID tags were successfully visualized at 10 dB above the background signal. Localization and identification are demonstrated using pulse inversion and image processing techniques.
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April 01 2022
Design of an electronic radiological clip for improved breast cancer imaging with ultrasound
J. Acoust. Soc. Am. 151, A245 (2022)
Jenna Cario, Michael L. Oelze; Design of an electronic radiological clip for improved breast cancer imaging with ultrasound. J. Acoust. Soc. Am. 1 April 2022; 151 (4_Supplement): A245. https://doi.org/10.1121/10.0011207
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