Ultrasonic bone assessment: backscatter difference measurements of the femoral neck in vivo

Introduction: Ultrasonic backscatter techniques are being developed to detect changes in bone caused by osteoporosis. The goal of this study was to evaluate the clinical utility of backscatter difference measurements at the femoral neck. Methods: Backscatter signals were acquired from the left and right femoral necks of 97 human volunteers using an ultrasonic imaging system (Terason T3000). The signals were analyzed to measure the normalized mean of the backscatter difference (nMBD), a quantity that represents the power difference between two portions of the same backscatter signal. Also, a bone sonometer (GE Achilles EXPII) was used to measure the stiffness index (SI) of the left and right heel bones. Results: Linear regression analysis was used to compare nMBD measurement at the femoral neck to SI measurements at the heel. A statistically significant (R ≥ 0.2) correlation was observed between nMBD and SI. Conclusion: These results suggest that nMBD is sensitive to naturally occurring variations in bone tissue, and thus may be able to detect larger changes in bone caused by osteoporosis.