The field of acoustofluidics studies the effects of acoustic waves transferred from piezoelectric solids to small volumes of fluid. The phenomenon of acoustofluidic atomization has been studied for several decades now, and one of its major proposed applications is in pulmonary drug delivery. It is well known that droplets in the 1 to 5 μm range are optimal for lung delivery. High-frequency, oriface-free, acoustic vibration has been shown to produce droplets in narrow size distributions including this range. Until now, this technology has not been practical for point-of-care. We have created the first portable acoustofluidic nebulizer as a proof of concept for this application. This device has been enabled by improved transducer design that can now be driven by standard COTS (commercial off-the-shelf) integrated circuits for efficient frequency-synthesis and power-delivery in the 5-25 MHz, 0.5–2 W range. We use a thickness mode transducer with reduced dimensions and incorporate an on-board resonance search algorithm in order to obtain a true thickness mode acoustic wave. We supply fluid from a wick in contact with the edge of the transducer and promote wetting of the surface via fine abrasion in order to obtain continuous atomization from a thin film. Our device nebulizes 0.1 ml/min of water in the critical 1 to 5 μm diameter range using a standard 3.7 V, rechargeable, lithium-ion battery.