Products incorporating stone-targeting microbubbles have recently entered human clinical trials as a new minimally-invasive approach to treat urinary stones. Lipid-shell, gas-core microbubbles can be introduced into the urinary tract through a catheter. Calcium-binding moieties incorporated into the lipid shell can facilitate binding to stones. The microbubbles can be excited by an extracorporeal source of low-intensity ultrasound. Alternatively, the microbubbles can be excited by an intraluminal source, such as a fiber-optic laser. With either excitation technique, stone-targeting microbubbles can significantly increase rates of erosion, pitting, and fragmentation of stones, as has recently been reported for in-vitro experiments with synthetic stones [Wiener et al., J. Urology, v.199, no.4S, e322 (2018)]. We report here on new experiments using high-speed photography to characterize microbubbles expansion of cracks within a stone and resultant breaking-off of stone fragments. Numerical modeling shows that the direction of microjets produced by collapsing stone-bound microbubbles depends strongly on bubble shape and stand-off distance. For a wide range of stand-off distances and bubble shapes, microbubble collapse is associated with pressure increases of some two orders of magnitude compared to the excitation source pressures. This in-vitro study provides key insights into the use of stone-targeting microbubbles in treatment of urinary stones.
Skip Nav Destination
Article navigation
Meeting abstract. No PDF available.
September 01 2018
Experimental observations and numerical modeling of lipid-shell microbubbles with stone targeting moieties for minimally-invasive treatment of urinary stones
Yuri A. Pishchalnikov;
Yuri A. Pishchalnikov
Applaud Medical Inc., 953 Indiana St., San Francisco, CA 94107, yurapish@gmail.com
Search for other works by this author on:
William Behnke-Parks;
William Behnke-Parks
Applaud Medical Inc., 953 Indiana St., San Francisco, CA 94107, yurapish@gmail.com
Search for other works by this author on:
Kazuki Maeda;
Kazuki Maeda
Dept. of Mech. Eng., Univ. of Washington, Seattle, WA
Search for other works by this author on:
Tim Colonius;
Tim Colonius
Dept. of Mech. and Civil Eng., California Inst. of Technol., Pasadena, CA
Search for other works by this author on:
Matt Mellema;
Matt Mellema
Applaud Medical Inc., San Francisco, CA
Search for other works by this author on:
Matt Hopcroft;
Matt Hopcroft
Applaud Medical Inc., San Francisco, CA
Search for other works by this author on:
Alice Luong;
Alice Luong
Applaud Medical Inc., San Francisco, CA
Search for other works by this author on:
Scott Wiener;
Scott Wiener
Dept. of Urology, Univ. of California, San Francisco, CA
Search for other works by this author on:
Marshall Stoller;
Marshall Stoller
Dept. of Urology, Univ. of California, San Francisco, CA
Search for other works by this author on:
Thomas Kenny;
Thomas Kenny
Dept. of Mech. Eng., Stanford Univ., Stanford, CA
Search for other works by this author on:
Daniel Laser
Daniel Laser
Applaud Medical Inc., San Francisco, CA
Search for other works by this author on:
J. Acoust. Soc. Am. 144, 1781 (2018)
Citation
Yuri A. Pishchalnikov, William Behnke-Parks, Kazuki Maeda, Tim Colonius, Matt Mellema, Matt Hopcroft, Alice Luong, Scott Wiener, Marshall Stoller, Thomas Kenny, Daniel Laser; Experimental observations and numerical modeling of lipid-shell microbubbles with stone targeting moieties for minimally-invasive treatment of urinary stones. J. Acoust. Soc. Am. 1 September 2018; 144 (3_Supplement): 1781. https://doi.org/10.1121/1.5067871
Download citation file:
10
Views
Citing articles via
Related Content
Experimental observations and numerical modeling of lipid-shell microbubbles with calcium-adhering moieties for minimally-invasive treatment of urinary stones
Proc. Mtgs. Acoust. (November 2018)
Urinary stone erosion and fragmentation under low-intensity quasi-collimated ultrasound using gas-filled microbubbles with stone-targeting lipid shells
J Acoust Soc Am (March 2018)
Urinary pH as a Risk Factor for Stone Type
AIP Conference Proceedings (April 2007)
Implications of Biofilm Formation on Urological Devices
AIP Conference Proceedings (September 2008)
Infrared Spectral Studies of Urinary Stones Resected from Urinary Bladder
AIP Conference Proceedings (November 2008)