Products incorporating stone-targeting microbubbles have recently entered human clinical trials as a new minimally-invasive approach to treat urinary stones. Lipid-shell, gas-core microbubbles can be introduced into the urinary tract through a catheter. Calcium-binding moieties incorporated into the lipid shell can facilitate binding to stones. The microbubbles can be excited by an extracorporeal source of low-intensity ultrasound. Alternatively, the microbubbles can be excited by an intraluminal source, such as a fiber-optic laser. With either excitation technique, stone-targeting microbubbles can significantly increase rates of erosion, pitting, and fragmentation of stones, as has recently been reported for in-vitro experiments with synthetic stones [Wiener et al., J. Urology, v.199, no.4S, e322 (2018)]. We report here on new experiments using high-speed photography to characterize microbubbles expansion of cracks within a stone and resultant breaking-off of stone fragments. Numerical modeling shows that the direction of microjets produced by collapsing stone-bound microbubbles depends strongly on bubble shape and stand-off distance. For a wide range of stand-off distances and bubble shapes, microbubble collapse is associated with pressure increases of some two orders of magnitude compared to the excitation source pressures. This in-vitro study provides key insights into the use of stone-targeting microbubbles in treatment of urinary stones.
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September 2018
Meeting abstract. No PDF available.
September 01 2018
Experimental observations and numerical modeling of lipid-shell microbubbles with stone targeting moieties for minimally-invasive treatment of urinary stones
Yuri A. Pishchalnikov;
Yuri A. Pishchalnikov
Applaud Medical Inc., 953 Indiana St., San Francisco, CA 94107, [email protected]
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William Behnke-Parks;
William Behnke-Parks
Applaud Medical Inc., 953 Indiana St., San Francisco, CA 94107, [email protected]
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Kazuki Maeda;
Kazuki Maeda
Dept. of Mech. Eng., Univ. of Washington, Seattle, WA
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Tim Colonius;
Tim Colonius
Dept. of Mech. and Civil Eng., California Inst. of Technol., Pasadena, CA
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Matt Mellema;
Matt Mellema
Applaud Medical Inc., San Francisco, CA
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Matt Hopcroft;
Matt Hopcroft
Applaud Medical Inc., San Francisco, CA
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Alice Luong;
Alice Luong
Applaud Medical Inc., San Francisco, CA
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Scott Wiener;
Scott Wiener
Dept. of Urology, Univ. of California, San Francisco, CA
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Marshall Stoller;
Marshall Stoller
Dept. of Urology, Univ. of California, San Francisco, CA
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Thomas Kenny;
Thomas Kenny
Dept. of Mech. Eng., Stanford Univ., Stanford, CA
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Daniel Laser
Daniel Laser
Applaud Medical Inc., San Francisco, CA
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Yuri A. Pishchalnikov
William Behnke-Parks
Kazuki Maeda
Tim Colonius
Matt Mellema
Matt Hopcroft
Alice Luong
Scott Wiener
Marshall Stoller
Thomas Kenny
Daniel Laser
Applaud Medical Inc., 953 Indiana St., San Francisco, CA 94107, [email protected]
J. Acoust. Soc. Am. 144, 1781 (2018)
Connected Content
A companion article has been published:
Experimental observations and numerical modeling of lipid-shell microbubbles with calcium-adhering moieties for minimally-invasive treatment of urinary stones
Citation
Yuri A. Pishchalnikov, William Behnke-Parks, Kazuki Maeda, Tim Colonius, Matt Mellema, Matt Hopcroft, Alice Luong, Scott Wiener, Marshall Stoller, Thomas Kenny, Daniel Laser; Experimental observations and numerical modeling of lipid-shell microbubbles with stone targeting moieties for minimally-invasive treatment of urinary stones. J. Acoust. Soc. Am. 1 September 2018; 144 (3_Supplement): 1781. https://doi.org/10.1121/1.5067871
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