Edwin Carstensen made significant contributions to the understanding of the interactions between ultrasound and biological tissues. He was especially interested in how acoustically-excited bubbles interact with biological systems. In his experiments, sources of these in vivo bubbles included gas in respiratory tubules of fruit fly larvae, ultrasound contrast agents, and gas in murine lung and intestine. While much of Ed’s work was experimental, he had keen insight and a unique perspective for understanding the mechanisms of the bioeffects. He realized that the shear strains in the vicinity of an oscillating bubble could be much greater than they would be if the bubble were not present. Not only was Ed a remarkable scientist, he was also a great mentor. When I first arrived at the University of Rochester, Ed introduced me to the field of biomedical ultrasound and the many outstanding researchers working in the area. It has been a great pleasure and rewarding experience to collaborate with Edwin Carstensen and his student, then close colleague, Diane Dalecki over that last 30 years. This paper will present some of our collaborative work on investigating the response of acoustically-excited bubbles and the stresses and strains induced in the surrounding media.