Here, we present results from experiments using histotripsy pulses backscattered off of therapy-generated bubble clouds to perform point-by-point aberration correction and bubble cloud localization transcranially over large steering ranges to demonstrate the efficacy of these methods at improving treatment efficiency and mapping volumetric treatments. Histotripsy pulses were delivered through an ex vivo human skullcap mounted centrally within a 500 kHz, 256-element histotripsy transducer with transmit-receive capable elements. Electronic focal steering was used to steer the therapy focus through individual points spanning a 30 mm diameter volume centered about the transducer's geometric focus. Backscatter signals from the generated bubble clouds were collected using array elements as receivers. Separate algorithms, based on time-domain information extracted from the collected signals, were used to perform aberration correction and localize the generated bubble clouds, respectively. The effectiveness of the aberration correction and localization results were assessed via comparison to hydrophone measurements of the focal pressure amplitude and location taken before and after backscatter aberration correction and localization were applied. Backscatter aberration correction results showed increased focal pressure amplitudes at all steering locations tested. Localization results were in good agreement with hydrophone measurements, but were seen to display preferential bias in the pre-focal direction at larger steering distances.
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Transcranial histotripsy acoustic-backscatter localization and aberration correction for volume treatments
Jonathan R. Sukovich, Zhen Xu, Timothy L. Hall, Jonathan J. Macoskey, Charles A. Cain; Transcranial histotripsy acoustic-backscatter localization and aberration correction for volume treatments. J. Acoust. Soc. Am. 1 May 2017; 141 (5_Supplement): 3490. https://doi.org/10.1121/1.4987285
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