The main problem on HIFU (High Intensity Focused Ultrasound) therapy is the difficulty to locate HIFU focus precisely onto the focal lesion, which is located in the moving organ such as livers/kidneys, due to the deformation and rotation, which is caused by respiration. Furthermore, rib bones frequently block the acoustic path to the lesion. The acoustic shadow, which is generated by the rib bone, is observed in the ultrasound images and the lesion is hidden in the shadow. To cope with this problem, we have developed a novel method to track, follow, and monitor the lesion by utilizing the contour information of the organ, which incorporate the lesion under those difficult conditions. As for the tracking method, the contour of the organ, which is deformed and rotated in accordance with respiration, is extracted automatically in 2-D ultrasound images. The missing contour information in the acoustic shadow area is estimated and compensated by the surrounding contours, which are successfully extracted. To confirm the effectiveness of the proposed method, we compared the proposed method with the conventional method in terms of the tracking performance of the stone. As a result, we achieved the tracking performance (the average servo error is 2.3 mm) by the proposed method, while the average servo error is 3.57 mm by the conventional method. This shows the validity of our novel proposed method.