Transient‐evoked otoacoustic emissions (TEOE) disappear when hearing loss exceeds 40 dB in the range 1–4 kHz, due to impairment of cochlear outer hair cells. Early screening of sensorineural hearing losses is based on this finding. However, little is known as to the frequency specificity of TEOE abnormalities in a damaged cochlea. TEOE were recorded in 18 normally hearing guinea pigs in a range from 1.5 to 5 kHz before and after exposure to loud pure tones (3–10 kHz, 95–105 dB SPL, 1–10 min). The thresholds of eighth‐nerve compound action potentials (CAP) were monitored with a round‐window electrode; it was confirmed that acoustic overexposure resulted in typical high‐frequency threshold elevations (10 to 50 dB). Most TEOE components were found at lower frequencies at which CAP thresholds did not change. However, a significant linear regression was found between their amplitudes and the percentage of basal cochlea with unaltered CAP thresholds (r=0.69, p<0.0001). Two alternative hypotheses are proposed to account for this correlation. Either acoustic trauma induced some minute cochlear damage at places tuned to low frequencies and TEOE were more sensitive to it than CAP thresholds, or significant contributions to lower‐frequency TEOE came from the most damaged cochlear places tuned to much higher frequencies.
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May 1995
May 01 1995
Transient‐evoked otoacoustic emissions and high‐frequency acoustic trauma in the guinea pig
Paul Avan;
Paul Avan
Biophysics Laboratory, Faculty of Medicine, University of Auvergne, P.O. Box 38, 63001 Clermont‐Ferrand Cedex 1, France
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Pierre Bonfils;
Pierre Bonfils
E.N.T. Department, Hospital Boucicaut, University Paris V, 78 rue de la Convention, 75015 Paris, France
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Drystan Loth;
Drystan Loth
Biophysics Department, Hospital Lariboisière, University Paris VII, 2 rue A.Paré, 75010 Paris, France
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Michel Elbez;
Michel Elbez
E.N.T. Department, Hospital Boucicaut, University Paris V, 78 rue de la Convention, 75015 Paris, France
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Manuel Erminy
Manuel Erminy
E.N.T. Department, Hospital Boucicaut, University Paris V, 78 rue de la Convention, 75015 Paris, France
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J. Acoust. Soc. Am. 97, 3012–3020 (1995)
Article history
Received:
January 26 1994
Accepted:
January 13 1995
Citation
Paul Avan, Pierre Bonfils, Drystan Loth, Michel Elbez, Manuel Erminy; Transient‐evoked otoacoustic emissions and high‐frequency acoustic trauma in the guinea pig. J. Acoust. Soc. Am. 1 May 1995; 97 (5): 3012–3020. https://doi.org/10.1121/1.411866
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