Applications of ultrasonics in neurosurgery involve the production of lesions of a specified size at a specified location, and in a reproducible fashion. Control of the dosage required for a given lesion depends on the geometry of the focal region, the exact determination of focal intensity and the relation between irradiation parameters and biological effect. From an analysis of these factors an optimum frequency for each focal depth is determined and an empirical dosage relationship based on ultrasonically produced paralysis in mice is stated. The mechanism of cell destruction by ultrasound is shown to be a temperature‐dependent mechanical effect originating at weak points in the tissue. The difficulties in extrapolating results obtained with experimental animals to applications in human neurosurgery are pointed out.

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