Phase aberration induced by soft tissue inhomogeneities often complicates high-intensity focused ultrasound (HIFU) therapies by distorting the field and, previously, we designed and fabricated a bilayer gel phantom to reproducibly mimic that effect. A surface pattern containing size scales relevant to inhomogeneities of a porcine body wall was introduced between gel materials with fat- and muscle-like acoustic properties—ballistic and polyvinyl alcohol gels. Here, the phantom design was refined to achieve relevant values of ultrasound absorption and scattering and make it more robust, facilitating frequent handling and use in various experimental arrangements. The fidelity of the interfacial surface of the fabricated phantom to the design was confirmed by three-dimensional ultrasound imaging. The HIFU field distortions—displacement of the focus, enlargement of the focal region, and reduction of focal pressure—produced by the phantom were characterized using hydrophone measurements with a 1.5 MHz 256-element HIFU array and found to be similar to those induced by an ex vivo porcine body wall. A phase correction approach was used to mitigate the aberration effect on nonlinear focal waveforms and enable boiling histotripsy treatments through the phantom or body wall. The refined phantom represents a practical tool to explore HIFU therapy systems capabilities.
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May 04 2022
Robust and durable aberrative and absorptive phantom for therapeutic ultrasound applications Available to Purchase
Alex T. Peek;
Alex T. Peek
1
Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington
, 1013 NE 40th Street, Seattle, Washington 98105, USA
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Gilles P. L. Thomas;
Gilles P. L. Thomas
1
Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington
, 1013 NE 40th Street, Seattle, Washington 98105, USA
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Daniel F. Leotta;
Daniel F. Leotta
1
Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington
, 1013 NE 40th Street, Seattle, Washington 98105, USA
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Petr V. Yuldashev;
Petr V. Yuldashev
2
Physics Faculty, Moscow State University
, Moscow 119991, Russia
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Vera A. Khokhlova;
Vera A. Khokhlova
a)
1
Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington
, 1013 NE 40th Street, Seattle, Washington 98105, USA
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Tatiana D. Khokhlova
Tatiana D. Khokhlova
b)
3
Division of Gastroenterology, Department of Medicine, University of Washington
, Seattle, Washington 98125, USA
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Alex T. Peek
1
Gilles P. L. Thomas
1
Daniel F. Leotta
1
Petr V. Yuldashev
2
Vera A. Khokhlova
1,a)
Tatiana D. Khokhlova
3,b)
1
Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington
, 1013 NE 40th Street, Seattle, Washington 98105, USA
2
Physics Faculty, Moscow State University
, Moscow 119991, Russia
3
Division of Gastroenterology, Department of Medicine, University of Washington
, Seattle, Washington 98125, USA
a)
Also at: Physics Faculty, Moscow State University, Moscow 119991, Russia.
b)
Also at: Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, 1013 NE 40th Street, Seattle, WA, 98105 USA. Electronic mail: [email protected]
J. Acoust. Soc. Am. 151, 3007–3018 (2022)
Article history
Received:
December 14 2021
Accepted:
April 12 2022
Citation
Alex T. Peek, Gilles P. L. Thomas, Daniel F. Leotta, Petr V. Yuldashev, Vera A. Khokhlova, Tatiana D. Khokhlova; Robust and durable aberrative and absorptive phantom for therapeutic ultrasound applications. J. Acoust. Soc. Am. 1 May 2022; 151 (5): 3007–3018. https://doi.org/10.1121/10.0010369
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