Stability and duration of ultrasonic phantoms are still subjects of research. This work presents a tissue-mimicking material (TMM) to evaluate high-intensity therapeutic ultrasound (HITU) devices, composed of gellan gum (matrix), microparticles (scatterers), and chemicals. The ultrasonic velocity and attenuation coefficient were characterized as a function of temperature (range 20 °C–85 °C). The nonlinear parameter B/A was determined by the finite amplitude insertion substitution (FAIS) method, and the shear modulus was determined by a transient elastography technique. The thermal conductivity and specific heat were determined by the line source method. The attenuation was stable for 60 days, and in an almost linear frequency dependence (0.51f0.96 dB cm−1), at 20 °C (1–10 MHz). All other evaluated physical parameters are also close to typical soft tissue values. Longitudinal ultrasonic velocities were between 1.49 and 1.75 mm μs−1, the B/A parameter was 7.8 at 30 °C, and Young's modulus was 23.4 kPa. The thermal conductivity and specific heat values were 0.7 W(m K)−1 and 4.7 kJ(kg K)−1, respectively. Consistent temperature increases and thermal doses occurred under identical HITU exposures. Low cost, longevity, thermal stability, and thermal repeatability make TMM an excellent material for ultrasonic thermal applications. The TMM developed has the potential to assess the efficacy of hyperthermia devices and could be used to adjust the ultrasonic emission of HITU devices.
References
1.
American Institute of Ultrasound in Medicine, Technical Standards Committee.
(1995
). Methods for Specifying Acoustic Properties of Tissue Mimicking Phantoms and Objects. Stage 1
(American Institute of Ultrasound in Medicine
, Laurel, MD
).2.
Anderson
, J. J.
, Herd
, M.-T.
, King
, M. R.
, Haak
, A.
, Hafez
, Z. T.
, Song
, J.
, Oelze
, M. L.
, Madsen
, E. L.
, Zagzebski
, J. A.
, O'Brien
, W. D.
, and Hall
, T. J.
(2010
). “Interlaboratory comparison of backscatter coefficient estimates for tissue-mimicking phantoms
,” Ultrason. Imaging
32
, 48
–64
.3.
Azhari
, H.
(2010
). “Appendix A: Typical acoustic properties of tissues
,” in Basics of Biomedical Ultrasound for Engineers
, 1st ed. (Wiley, Hoboken, NJ), pp. 313
–314
.4.
Bamber
, J. C.
, and Hill
, C. R.
(1979
). “Ultrasonic attenuation and propagation speed in mammalian tissues as a function of temperature
,” Ultrasound Med. Biol.
5
, 149
–157
.5.
Benech
, N.
, and Negreira
, C. A.
(2005
). “Longitudinal and lateral low frequency head wave analysis in soft media
,” J. Acoust. Soc. Am.
117
, 3424
–3431
.6.
Bethesda
, M.
(1998
). “Tissue substitutes, phantoms and computational modeling in medical ultrasound
,” ICRU Report 61, 132
pp.7.
Beyer
, R. T.
(1973
). Nonlinear Acoustics (Naval Ship Systems Command, Providence, RI), 414 pp., available at www.dtic.mil/get-tr-doc/pdf?AD=ADA098556 (Last viewed December 2, 2019).8.
Campbell
, G. S.
, Huffaker
, E. M.
, Wacker
, B. T.
, and Wacker
, K. C.
(2005
). “Use of the line heat source method to measure thermal conductivity of insulation and other porous materials
,” in Proc. Twenty-Seventh International Thermal Conductivity Conference (ITCC) and Proceedings of the Eighteenth International Thermal Expansion Symposium (ITES) (Thermal Conduct. 27/ Therm. Expans. 15)
, edited by H.
Wang
and W.
Porter
(DEStech
, Knoxville, TN)
, pp. 187
–195
.9.
Cassanelli
, M.
, Norton
, I.
, and Mills
, T.
(2017
). “Effect of alcohols on gellan gum gel structure: Bridging the molecular level and the three-dimensional network
,” Food Struct.
14
, 112
–120
.10.
Chen
, R. K.
, and Shih
, A. J.
(2013
). “Multi-modality gellan gum-based tissue-mimicking phantom with targeted mechanical, electrical, and thermal properties
,” Phys. Med. Biol.
58
, 5511
–5525
.11.
12.
Clarke
, R. L.
, Bush
, N. L.
, and Ter Haar
, G. R.
(2003
). “The changes in acoustic attenuation due to in vitro heating
,” Ultrasound Med. Biol.
29
, 127
–135
.13.
Cortela
, G.
, Lima
, K. M.
, Maggi
, L. E.
, Negreira
, C.
, and Pereira
, W. C. A.
(2015
). “Evaluation of acoustic and thermal properties of gellan-gum phantom to mimic biological tissue
,” in 2015 Pan American Health Care Exchanges
(IEEE
, New York
), pp. 1
–4
.14.
Dong
, F.
, Madsen
, E. L.
, MacDonald
, M. C.
, and Zagzebski
, J. A.
(1999
). “Nonlinearity parameter for tissue-mimicking materials
,” Ultrasound Med. Biol.
25
, 831
–838
.15.
Duck
, F. A.
(1990
). Physical Properties of Tissue: A Complete Reference Book
(Academic
, London
), pp. 9
–37
.16.
Filonenko
, E. A.
, and Khokhlova
, V. A.
(2001
). “Effect of acoustic nonlinearity on heating of biological tissue by high-intensity focused ultrasound
,” Acoust. Phys.
47
, 468
–475
.17.
Franchi-Abella
, S.
, Elie
, C.
, and Correas
, J.-M.
(2013
). “Ultrasound elastography: Advantages, limitations and artefacts of the different techniques from a study on a phantom
,” Diagn. Interv. Imaging
94
, 497
–501
.18.
Gammell
, P. M.
, Le Croissette
, D. H.
, and Heyser
, R. C.
(1979
). “Temperature and frequency dependence of ultrasonic attenuation in selected tissues
,” Ultrasound Med. Biol.
5
, 269
–277
.19.
Gennisson
, J.-L.
, Deffieux
, T.
, Fink
, M.
, and Tanter
, M.
(2013
). “Ultrasound elastography: Principles and techniques
,” Diagn. Interv. Imaging
94
, 487
–495
.20.
Gertner
, M. R.
, Wilson
, B. C.
, and Sherar
, M. D.
(1997
). “Ultrasound properties of liver tissue during heating
,” Ultrasound Med. Biol.
23
, 1395
–1403
.21.
Giavasis
, I.
, Harvey
, L. M.
, and McNeil
, B.
(2000
). “Gellan gum
,” Crit. Rev. Biotechnol.
20
, 177
–211
.22.
Gong
, X.
, Zhu
, Z.
, Shi
, T.
, and Huang
, J.
(1989
). “Determination of the acoustic nonlinearity parameter in biological media using FAIS and ITD methods
,” J. Acoust. Soc. Am.
86
, 1
–5
.23.
Hall
, T. J.
, Bilgen
, M.
, Insana
, M. F.
, and Krouskop
, T. A.
(1997
). “Phantom materials for elastography
,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control
44
, 1355
–1365
.24.
Hariharan
, P.
, Myers
, M. R.
, and Banerjee
, R. K.
(2007
). “HIFU procedures at moderate intensities—Effect of large blood vessels
,” Phys. Med. Biol.
52
, 3493
–3513
.25.
Harris
, G. R.
, Liu
, Y.
, Maruvada
, S.
, and Gammell
, P. M.
(2007
). “P4H-1 finite amplitude method for measurement of nonlinearity parameter B/A using plane-wave tone bursts
,” in 2007 IEEE Ultrasonics Symposium Proceedings
, pp. 2072
–2074
.26.
Holt
, R. G.
, and Roy
, R. A.
(2001
). “Measurements of bubble-enhanced heating from focused, MHz-frequency ultrasound in a tissue-mimicking material
,” Ultrasound Med. Biol.
27
, 1399
–412
.27.
Huang
, J.
, Holt
, R. G.
, Cleveland
, R. O.
, and Roy
, R. A.
(2004
). “Experimental validation of a tractable numerical model for focused ultrasound heating in flow-through tissue phantoms
,” J. Acoust. Soc. Am.
116
, 2451
–2458
.28.
IEC
(2006
). 62306 ed. 1, Ultrasonics—Field Characterisation—Test Objects for Determining Temperature Elevation in Diagnostic Ultrasound Fields
(International Electrotechnical Commission
, Geneva, Switzerland
), 75
pp.29.
IEC
(2007
). 60601-2-37 ed. 2, Medical Electrical Equipment—Part 2-37: Particular Requirements for the Basic Safety and Essential Performance of Ultrasonic Medical Diagnostic and Monitoring Equipment
(International Electrotechnical Commission
, Geneva, Switzerland
).30.
Jansson
, P.-E.
, Lindberg
, B.
, and Sandford
, P. A.
(1983
). “Structural studies of gellan gum, an extracellular polysaccharide elaborated by Pseudomonas elodea
,” Carbohydr. Res.
124
, 135
–139
.31.
Kennedy
, J. E.
, ter Haar
, G. R.
, Wu
, F.
, Gleeson
, F. V.
, Roberts
, I. S.
, Middleton
, M. R.
, and Cranston
, D.
(2004
). “Contrast-enhanced ultrasound assessment of tissue response to high-intensity focused ultrasound
,” Ultrasound Med. Biol.
30
, 851
–854
.32.
King
, R. L.
, Herman
, B. A.
, Maruvada
, S.
, Wear
, K. A.
, and Harris
, G. R.
(2007
). “Development of a HIFU phantom
,” AIP Conf. Proc.
911
, 351
–356
.33.
King
, R. L.
, Liu
, Y.
, Maruvada
, S.
, Herman
, B. A.
, Wear
, K. A.
, and Harris
, G. R.
(2011
). “Development and characterization of a tissue-mimicking material for high-intensity focused ultrasound
,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control
58
, 1397
–1405
.34.
Ma
, S.
, Kong
, Y. K.
, Ahn
, Y. M.
, and Park
, K. J.
(2004
). “Development of an ultrasound training phantom of the thyroid gland: Physical characteristics of TMM
,” Jpn. J. Radiol. Technol.
60
, 1459
–1466
.35.
Madsen
, E. L.
, Dong
, F.
, Frank
, G. R.
, Garra
, B. S.
, Wear
, K. A.
, Wilson
, T.
, Zagzebski
, J. A.
, Miller
, H. L.
, Shung
, K. K.
, Wang
, S. H.
, Feleppa
, E. J.
, Liu
, T.
, O'Brien
, W. D.
, Jr., Topp
, K. A.
, Sanghvi
, N. T.
, Zaitsev
, A. V.
, Hall
, T. J.
, Fowlkes
, J. B.
, Kripfgans
, O. D.
, and Miller
, J. G.
(1999
). “Interlaboratory comparison of ultrasonic backscatter, attenuation, and speed measurements
,” J. Ultrasound Med.
18
, 615
–631
.36.
Madsen
, E. L.
, Frank
, G. R.
, and Dong
, F.
(1998
). “Liquid or solid ultrasonically tissue-mimicking materials with very low scatter
,” Ultrasound Med. Biol.
24
, 535
–542
.37.
Madsen
, E. L.
, Zagzebski
, J. A.
, and Frank
, G. R.
(1982a
). “Oil-in-gelatin dispersions for use as ultrasonically tissue-mimicking materials
,” Ultrasound Med. Biol.
8
, 277
–287
.38.
Madsen
, E. L.
, Zagzebski
, J. A.
, and Frank
, G. R.
(1982b
). “An anthropomorphic ultrasound breast phantom containing intermediate-sized scatterers
,” Ultrasound Med. Biol.
8
, 381
–392
.39.
Mao
, R.
, Tang
, J.
, and Swanson
, B. G.
(2000
). “Texture properties of high and low acyl mixed gellan gels
,” Carbohydr. Polym.
41
, 331
–338
.40.
Mariappan
, Y. K.
, Glaser
, K. J.
, and Ehman
, R. L.
(2010
). “Magnetic resonance elastography: A review
,” Clin. Anat.
23
, 497
–511
.41.
Morris
, E. R.
, Nishinari
, K.
, and Rinaudo
, M.
(2012
). “Gelation of gellan—A review
,” Food Hydrocoll.
28
, 373
–411
.42.
Ophir
, J.
(1991
). “Elastography: A quantitative method for imaging the elasticity of biological tissues
,” Ultrason. Imaging
13
, 111
–134
.43.
Parker
, K. J.
, Doyley
, M. M.
, and Rubens
, D. J.
(2011
). “Imaging the elastic properties of tissue: The 20 year perspective
,” Phys. Med. Biol.
56
, R1
–R29
.44.
Phillips
, G. O.
, and Williams
, P. A.
(2009
). Handbook of Hydrocolloids
(Woodhead
, Sawston, UK
), 944
pp.45.
Sandrin
, L.
, Cassereau
, D.
, and Fink
, M.
(2004
). “The role of the coupling term in transient elastography
,” J. Acoust. Soc. Am.
115
, 73
–83
.46.
Sandrin
, L.
, Tanter
, M.
, Gennisson
, J.-L.
, Catheline
, S.
, and Fink
, M.
(2002
). “Shear elasticity probe for soft tissues with 1-D transient elastography
,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control
49
, 436
–446
.47.
Sehgal
, C. M.
, Bahn
, R. C.
, and Greenleaf
, J. F.
(1984
). “Measurement of the acoustic nonlinearity parameter B/A in human tissues by a thermodynamic method
,” J. Acoust. Soc. Am.
76
, 1023
–1029
.48.
Sherar
, M. D.
, Trachtenberg
, J.
, Davidson
, S. R. H.
, and Gertner
, M. R.
(2004
). “Interstitial microwave thermal therapy and its application to the treatment of recurrent prostate cancer
,” Int. J. Hyperthermia
20
, 757
–768
.49.
Soneson
, J. E.
, and Myers
, M. R.
(2010
). “Thresholds for nonlinear effects in high-intensity focused ultrasound propagation and tissue heating
,” IEEE Trans. Ultrason. Ferroelectr. Freq. Control
57
, 2450
–2459
.50.
Techavipoo
, U.
, Varghese
, T.
, Chen
, Q.
, Stiles
, T. A.
, Zagzebski
, J. A.
, and Frank
, G. R.
(2004
). “Temperature dependence of ultrasonic propagation speed and attenuation in excised canine liver tissue measured using transmitted and reflected pulses
,” J. Acoust. Soc. Am.
115
, 2859
–2865
.51.
van Dongen
, K. W. A.
, and Verweij
, M. D.
(2011
). “A feasibility study for non-invasive thermometry using non-linear ultrasound
,” Int. J. Hyperth.
27
, 612
–624
.52.
Wear
, K. A.
, Stiles
, T. A.
, Frank
, G. R.
, Madsen
, E. L.
, Cheng
, F.
, Feleppa
, E. J.
, Hall
, C. S.
, Kim
, B. S.
, Lee
, P.
, O'Brien
, W. D.
, Jr., Oelze
, M. L.
, Raju
, B. I.
, Shung
, K. K.
, Wilson
, T. A.
, and Yuan
, J. R.
(2005
). “Interlaboratory comparison of ultrasonic backscatter coefficient measurements from 2 to 9 MHz
,” J. Ultrasound Med.
24
, 1235
–1250
.53.
Wells
, P. N. T.
, and Liang
, H.-D.
(2011
). “Medical ultrasound: Imaging of soft tissue strain and elasticity
,” J. R. Soc. Interface
8
, 1521
–1549
.54.
Worthington
, A.
, and Sherar
, M.
(2001
). “Changes in ultrasound properties of porcine kidney tissue during heating
,” Ultrasound Med. Biol.
27
, 673
–682
.55.
Wu
, F.
, Wang
, Z.-B.
, Chen
, W.-Z.
, Zou
, J.-Z.
, Bai
, J.
, Zhu
, H.
, Li
, K. Q.
, Xie
, F. L.
, Jin
, C. B.
, Su
, H. B.
, and Gao
, G. W.
(2004
). “Extracorporeal focused ultrasound surgery for treatment of human solid carcinomas: Early Chinese clinical experience
,” Ultrasound Med. Biol.
30
, 245
–260
.56.
Zhang
, M.
, Castaneda
, B.
, Wu
, Z.
, Nigwekar
, P.
, Joseph
, J. V.
, Rubens
, D. J.
, and Parker
, K. J.
(2007
). “Congruence of imaging estimators and mechanical measurements of viscoelastic properties of soft tissues
,” Ultrasound Med. Biol.
33
, 1617
–1631
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