Although the maximum length sequence (MLS) and iterative randomized stimulation and averaging (I-RSA) methods allow auditory brainstem response (ABR) measurements at high rates, it is not clear if high rates allow ABRs of a given quality to be measured in less time than conventional (CONV) averaging (i.e., fixed interstimulus intervals) at lower rates. In the present study, ABR signal-to-noise ratio (SNR) was examined in six bottlenose dolphins as a function of measurement time and click rate using CONV averaging at rates of 25 and 100 Hz and the MLS/I-RSA approaches at rates from 100 to 1250 Hz. Residual noise in the averaged ABR was estimated using (1) waveform amplitude following the ABR, (2) waveform amplitude after subtracting two subaverage ABRs (i.e., the “±average”), and (3) amplitude variance at a single time point. Results showed that high stimulus rates can be used to obtain dolphin ABRs with a desired SNR in less time than CONV averaging. Optimal SNRs occurred at rates of 500–750 Hz, but were only a few dB higher than that for CONV averaging at 100 Hz. Nonetheless, a 1-dB improvement in SNR could result in a 25% time savings in reaching criterion SNR.

1.
Bohórquez
,
J.
, and
Özdamar
,
O.
(
2006
). “
Signal to noise ratio analysis of maximum length sequence deconvolution of overlapping evoked potentials
,”
J. Acoust. Soc. Am.
119
,
2881
2888
.
2.
Burkard
,
R.
,
Durand
,
B.
,
Secor
,
C.
, and
McFadden
,
S.
(
2001
).
“Auditory brainstem response in a mouse with deletion of the Rab3a gene,”
in
Handbook of Mouse Auditory Research: From Behavior to Molecular Biology
, edited by
J.
Willott
(
CRC Press
,
Boca Raton, FL
), pp.
603
615
.
3.
Burkard
,
R.
,
Finneran
,
J. J.
, and
Mulsow
,
J.
(
2018
). “
Comparison of maximum length sequence and randomized stimulation and averaging methods on the bottlenose dolphin auditory brainstem response
,”
J. Acoust. Soc. Am.
144
,
308
318
.
4.
Burkard
,
R. F.
,
Finneran
,
J. J.
,
Mulsow
,
J.
, and
Houser
,
D. S.
(
2017
). “
The effects of click rate on the auditory brainstem response (ABR) of the bottlenose dolphin
,”
J. Acoust. Soc. Am.
141
,
3396
3406
.
5.
Burkard
,
R.
, and
Hecox
,
K. E.
(
1987
). “
The effect of broadband noise on the human brain-stem auditory evoked response. III. Anatomic locus
,”
J. Acoust. Soc. Am.
81
,
1050
1072
.
6.
Burkard
,
R.
,
Jones
,
S.
, and
Jones
,
T.
(
1994
). “
Conventional and cross-correlation brain-stem auditory evoked responses in the white leghorn chick: Rate manipulations
,”
J. Acoust. Soc. Am.
95
,
2136
2144
.
7.
Burkard
,
R. F.
,
McGee
,
J.
, and
Walsh
,
E.
(
1996a
). “
Effects of stimulus rate on the feline brain-stem auditory evoked response during development. II. Peak amplitudes
,”
J. Acoust. Soc. Am.
100
,
991
1002
.
8.
Burkard
,
R. F.
,
McGee
,
J.
, and
Walsh
,
E. J.
(
1996b
). “
Effects of stimulus rate on the feline brain-stem auditory evoked response during development. I. Peak latencies
,”
J. Acoust. Soc. Am.
100
,
978
990
.
9.
Burkard
,
R.
,
Shi
,
Y.
, and
Hecox
,
K. E.
(
1990
). “
A comparison of maximum length and Legendre sequences for the derivation of brain-stem auditory-evoked responses at rapid rates of stimulation
,”
J. Acoust. Soc. Am.
87
,
1656
1664
.
10.
Burkard
,
R. F.
, and
Sims
,
D.
(
2001
). “
The human auditory brainstem response to high click rates: Aging effects
,”
Am. J. Audiol.
10
,
53
61
.
11.
Burkard
,
R.
, and
Voigt
,
H. F.
(
1989
). “
Stimulus dependencies of the gerbil brain-stem auditory-evoked response (BAER). I: Effects of click level, rate, and polarity
,”
J. Acoust. Soc. Am.
85
,
2514
2525
.
12.
Cook
,
M. L. H.
,
Varela
,
R. A.
,
Goldstein
,
J. D.
,
McCulloch
,
S. D.
,
Bossart
,
G. D.
,
Finneran
,
J. J.
,
Houser
,
D. S.
, and
Mann
,
D. A.
(
2006
). “
Beaked whale auditory evoked potential hearing measurements
,”
J. Comp. Physiol. A
192
,
489
495
.
13.
Delgado
,
R. E.
, and
Özdamar
,
O.
(
2004
). “
Deconvolution of evoked responses obtained at high stimulus rates
,”
J. Acoust. Soc. Am.
115
,
1242
1251
.
14.
Don
,
M.
,
Elberling
,
C.
, and
Waring
,
M.
(
1984
). “
Objective detection of averaged auditory brainstem responses
,”
Scand. Audiol.
13
,
219
228
.
15.
Elberling
,
C.
, and
Don
,
M.
(
1984
). “
Quality estimation of averaged auditory brainstem responses
,”
Scand. Audiol.
13
,
187
197
.
16.
Eysholdt
,
U.
, and
Schreiner
,
C.
(
1981
). “
Maximum length sequences—A fast method for measuring brainstem auditory evoked responses
,” in
IEEE Proceedings
, pp.
306
309
.
17.
Finneran
,
J. J.
(
2008
). “
Modified variance ratio for objective detection of transient evoked potentials in bottlenose dolphins (Tursiops truncatus)
,”
J. Acoust. Soc. Am.
124
,
4069
4082
.
18.
Finneran
,
J. J.
(
2017
). “
Bottlenose dolphin (Tursiops truncatus) auditory brainstem responses recorded using conventional and randomized stimulation and averaging
,”
J. Acoust. Soc. Am.
142
,
1034
1042
.
19.
Finneran
,
J. J.
,
Mulsow
,
J.
,
Houser
,
D. S.
, and
Burkard
,
R. F.
(
2016
). “
Place specificity of the click-evoked auditory brainstem response in the bottlenose dolphin (Tursiops truncatus)
,”
J. Acoust. Soc. Am.
140
,
2593
2602
.
20.
Jewett
,
D. L.
, and
Williston
,
J. S.
(
1971
). “
Auditory-evoked far fields averaged from the scalp of humans
,”
Brain
94
,
681
696
.
21.
Mulsow
,
J.
,
Finneran
,
J. J.
,
Houser
,
D. S.
, and
Burkard
,
R. F.
(
2016
). “
The effects of click and masker spectrum on the auditory brainstem response of bottlenose dolphins (Tursiops truncatus)
,”
J. Acoust. Soc. Am.
140
,
2603
2613
.
22.
Nachtigall
,
P. E.
,
Yuen
,
M. M. L.
,
Mooney
,
T. A.
, and
Taylor
,
K. A.
(
2005
). “
Hearing measurements from a stranded infant Risso's dolphin, Grampus griseus
,”
J. Exp. Biol.
208
,
4181
4188
.
23.
OriginLab
(
2018
). “
OriginPro (version 2018) [computer software]
” (OriginLab Corporation, Northampton, MA).
24.
Özdamar
,
O.
, and
Bohórquez
,
J.
(
2006
). “
Signal-to-noise ratio and frequency analysis of continuous loop averaging deconvolution (CLAD) of overlapping evoked potentials
,”
J. Acoust. Soc. Am.
119
,
429
438
.
25.
Picton
,
T. W.
,
Champagne
,
S. C.
, and
Kellett
,
A. J.
(
1992
). “
Human auditory evoked potentials recorded using maximum length sequences
,”
Electroencephalogr. Clin. Neurophysiol.
84
,
90
100
.
26.
Popov
,
V.
, and
Supin
,
A. Y.
(
1990
).
“Electrophysiological studies of hearing in some cetaceans and a manatee,”
in
Sensory Abilities in Cetaceans
, edited by
J. A.
Thomas
and
R. A.
Kastelein
(
Plenum
,
New York
), pp.
405
415
.
27.
Reichmuth
,
C.
,
Mulsow
,
J.
,
Finneran
,
J. J.
,
Houser
,
D. S.
, and
Supin
,
A. Y.
(
2007
). “
Measurement and response characteristics of auditory brainstem responses in pinnipeds
,”
Aquat. Mammal.
33
,
132
150
.
28.
Ridgway
,
S. H.
,
Bullock
,
T. H.
,
Carder
,
D. A.
,
Seeley
,
R. L.
,
Woods
,
D.
, and
Galambos
,
R.
(
1981
). “
Auditory brainstem response in dolphins
,”
Proc. Natl. Acad. Sci. U.S.A.
78
,
1943
1947
.
29.
Ridgway
,
S. H.
, and
Carder
,
D. A.
(
2001
). “
Assessing hearing and sound production in cetaceans not available for behavioral audiograms: Experiences with sperm, pygmy sperm, and gray whales
,”
Aquat. Mammal.
27
,
267
276
.
30.
Schimmel
,
H.
(
1967
). “
The (±) reference: Accuracy of estimated mean components in average response studies
,”
Science
157
,
92
94
.
31.
Stürzebecher
,
E.
,
Cebulla
,
M.
, and
Wernecke
,
K.-D.
(
2001
). “
Objective detection of transiently evoked otoacoustic emissions
,”
Scand. Audiol.
30
,
78
88
.
32.
Valderrama
,
J. T.
,
Alvarez
,
I.
,
de la Torre
,
A.
,
Carlos Segura
,
J.
,
Sainz
,
M.
, and
Luis Vargas
,
J.
(
2012
). “
Recording of auditory brainstem response at high stimulation rates using randomized stimulation and averaging
,”
J. Acoust. Soc. Am.
132
,
3856
3865
.
33.
Valderrama
,
J. T.
,
de la Torre
,
A.
,
Alvarez
,
I. M.
,
Segura
,
J. C.
,
Thornton
,
A. R. D.
,
Sainz
,
M.
, and
Vargas
,
J. L.
(
2014
). “
Auditory brainstem and middle latency responses recorded at fast rates with randomized stimulation
,”
J. Acoust. Soc. Am.
136
,
3233
3248
.
34.
Wong
,
P. K. H.
, and
Bickford
,
R. G.
(
1980
). “
Brain stem auditory evoked potentials: The use of noise estimate
,”
Electroencephalogr. Clin. Neurophysiol.
50
,
25
34
.
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