Many cases of disturbed voice signals can be attributed to incomplete glottal closure, vocal fold oscillation asymmetries, and aperiodicity. Often these phenomena occur simultaneously and interact with each other, making a systematic, isolated investigation challenging. Therefore, ex vivo porcine experiments were performed which enable direct control of glottal configurations. Different pre-phonatory glottal gap sizes, adduction levels, and flow rates were adjusted. The resulting glottal closure types were identified in a post-processing step. Finally, the acoustic quality, aerodynamic parameters, and the characteristics of vocal fold oscillation were analyzed in reference to the glottal closure types. Results show that complete glottal closure stabilizes the phonation process indicated through a reduced left-right phase asymmetry, increased amplitude and time periodicity, and an increase in the acoustic quality. Although asymmetry and periodicity parameter variation covers only a small range of absolute values, these small variations have a remarkable influence on the acoustic quality. Due to the fact that these parameters cannot be influenced directly, the authors suggest that the (surgical) reduction of the glottal gap seems to be a promising method to stabilize the phonatory process, which has to be confirmed in future studies.

1.
R. J.
Ruben
, “
Redefining the survival of the fittest: Communication disorders in the 21st century
,”
Laryngoscope
110
,
241
245
(
2000
).
2.
N.
Isshiki
,
H.
Morita
,
H.
Okamura
, and
M.
Hiramoto
, “
Thyroplasty as a new phonosurgical technique
,
Acta Oto-Laryngol.
78
,
451
457
(
1974
).
3.
E. C.
Inwald
,
M.
Döllinger
,”
M.
Schuster
,
U.
Eysholdt
, and
C.
Bohr
, “
Multiparametric analysis of vocal fold vibrations in healthy and disordered voices in high-speed imaging
,”
J. Voice
25
,
576
590
(
2011
).
4.
M. R.
Hoffman
,
K.
Surender
,
E. E.
Devine
, and
J. J.
Jiang
, “
Classification of glottic insufficiency and tension asymmetry using a multilayer perceptron
,”
Laryngoscope
122
,
2773
2780
(
2012
).
5.
J. B.
Park
and
L.
Mongeau
, “
Experimental investigation of the influence of a posterior gap on glottal flow and sound
,”
J. Acoust. Soc. Am.
124
,
1171
1179
(
2008
).
6.
C.
Sittel
,
N.
Bosch
, and
P. K.
Plinkert
, “
Surgical voice rehabilitation in unilateral vocal fold paralysis
,”
Chirurg.
79
,
1055
1064
(
2008
) (in German).
7.
P. S.
Mallur
and
C. A.
Rosen
, “
Vocal fold injection: Review of indications, techniques, and materials for augmentation
,”
Clin. Exp. Otorhinolar.
3
,
177
182
(
2010
).
8.
K.
Inagi
,
N. P.
Connor
,
T.
Suzuki
,
D. M.
Bless
, and
T.
Kamijo
, “
Visual observations of glottal configuration and vocal outcomes in arytenoid adduction
,”
Am. J. Otolaryng.
24
,
290
296
(
2003
).
9.
J.
Siu
,
S.
Tam
, and
K.
Fung
, “
A comparison of outcomes in interventions for unilateral vocal fold paralysis: A systematic review
,”
Laryngoscope
126
,
1616
1624
(
2016
).
10.
R. R.
Patel
,
A.
Dixon
,
A.
Richmond
, and
K. D.
Donohue
, “
Pediatric high speed digital imaging of vocal fold vibration: A normative pilot study of glottal closure and phase closure characteristics
,”
Int. J. Pediatr. Otorhinolaryngol.
76
,
954
959
(
2012
).
11.
M.
Södersten
and
P.
Lindestad
, “
Glottal closure and perceived breathiness during phonation in normally speaking subjects
,”
J. Speech Lang. Hear. Res.
33
,
601
611
(
1990
).
12.
M.
Sördersten
,
S.
Hertegard
, and
B.
Hammarberg
, “
Glottal closure, transglottal airflow, and voice quality in healthy middle-aged women
,”
J. Voice
9
,
182
197
(
1995
).
13.
K. A.
Kendall
, “
High-speed digital imaging of the larynx: Recent advances
,”
Curr. Opin. Otolaryngol. Head Neck Surg.
20
,
466
471
(
2012
).
14.
D. D.
Mehta
,
D. D.
Deliyski
,
T. F.
Quatieri
, and
R. E.
Hillman
, “
Automated measurement of vocal fold vibratory asymmetry from high-speed videoendoscopy recordings
,”
J. Speech Lang. Hear. Res.
54
,
47
54
(
2011
).
15.
I. M.
Verdonck-de Leeuw
,
J. M.
Festen
, and
H. F.
Mahieu
, “
Deviant vocal fold vibration as observed during videokymography: The effect on voice quality
,”
J. Voice
15
,
313
322
(
2001
).
16.
U.
Eysholdt
,
F.
Rosanowski
, and
U.
Hoppe
, “
Vocal fold vibration irregularities caused by different types of laryngeal asymmetry
,”
Eur. Arch. Otorhinolaryngol.
260
,
412
417
(
2003
).
17.
A.
Yamauchi
,
H.
Imagawa
,
K.
Sakakibara
,
H.
Yokonishi
,
T.
Nito
,
T.
Yamasoba
, and
N.
Tayama
, “
Phase difference of vocally healthy subjects in high-speed digital imaging analyzed with laryngotopography
,”
J. Voice
27
,
39
45
(
2013
).
18.
A.
Krenmayr
,
T.
Wöllner
,
N.
Supper
, and
P.
Zorowka
, “
Visualizing phase relations of the vocal folds by means of high-speed videoendoscopy
,”
J. Voice
26
,
471
479
(
2012
).
19.
P.
Lindestad
,
S.
Hertegard
, and
G.
Björck
, “
Laryngeal adduction asymmetries in normal speaking subjects
,”
Logoped. Phoniatr. Vocol.
29
,
128
134
(
2004
).
20.
Z.
Zhang
,
J.
Kreiman
,
B. R.
Gerratt
, and
M.
Garellek
, “
Acoustic and perceptual effects of changes in body layer stiffness in symmetric and asymmetric vocal fold models
,”
J. Acoust. Soc. Am.
133
,
453
462
(
2013
).
21.
R. A.
Samlan
,
B. H.
Story
,
A. J.
Lotto
, and
K.
Bunton
, “
Acoustic and perceptual effects of left-right laryngeal asymmetries based on computational modeling
,”
J. Speech. Lang. Hear. Res.
57
,
1619
1637
(
2014
).
22.
D. D.
Mehta
,
M.
Zañartu
,
T. F.
Quatieri
,
D. D.
Deliyski
, and
R. E.
Hillman
, “
Investigating acoustic correlates of human vocal fold vibratory phase asymmetry through modeling and laryngeal high-speed videoendoscopy
,”
J. Acoust. Soc. Am.
130
,
3999
4009
(
2011
).
23.
D. D.
Deliyski
,
P. P.
Petrushev
,
H. S.
Bonilha
,
T. T.
Gerlach
,
B.
Martin-Harris
, and
R. E.
Hillman
, “
Clinical implementation of laryngeal high-speed videoendoscopy: Challenges and evolution
,”
Folia. Phoniatr. Logop.
60
,
33
44
(
2008
).
24.
D. D.
Mehta
,
S. M.
Zeitels
,
J. A.
Burns
,
A. D.
Friedman
,
D. D.
Deliyski
, and
R. E.
Hillman
, “
High-speed videoendoscopic analysis of relationships between cepstral-based acoustic measures and voice production mechanisms in patients undergoing phonomicrosurgery
,”
Ann. Otol. Rhinol. Laryngol.
121
,
341
347
(
2012
).
25.
D. M.
Biever
and
D. M.
Bless
, “
Vibratory characteristics of the vocal folds in young adult and geriatric women
,”
J. Voice
3
,
120
131
(
1989
).
26.
F.
Alipour
and
S.
Jaiswal
, “
Phonatory characteristics of excised pig, sheep, and cow larynges
,”
J. Acoust. Soc. Am.
123
,
4572
4581
(
2008
).
27.
F.
Alipour
and
S.
Jaiswal
, “
Glottal airflow resistance in excised pig, sheep, and cow larynges
,”
J. Voice
23
,
40
50
(
2009
).
28.
R. W.
Chan
and
I. R.
Titze
, “
Effect of postmortem changes and freezing on the viscoelastic properties of vocal fold tissues
,”
Ann. Biomed. Eng.
31
,
482
491
(
2003
).
29.
V.
Birk
,
M.
Döllinger
,
A.
Sutor
,
D. A.
Berry
,
D.
Gedeon
,
M.
Traxdorf
,
O.
Wendler
,
C.
Bohr
, and
S.
Kniesburges
, “
Automated setup for ex vivo larynx experiments
,”
J. Acoust. Soc. Am.
141
,
1349
1359
(
2017
).
30.
Jw.
van den Berg
,
J. T.
Zantema
, and
P.
Doornenbal
, “
On the air resistance and the Bernoulli effect of the human larynx
,”
J. Acoust. Soc. Am.
29
,
626
631
(
1957
).
31.
M.
Döllinger
,
M.
Kunduk
,
M.
Kaltenbacher
,
S.
Vondenhoff
,
A.
Ziethe
,
U.
Eysholdt
, and
C.
Bohr
, “
Analysis of vocal fold function from acoustic data simultaneously recorded with high-speed endoscopy
,”
J. Voice
26
,
726
733
(
2012
).
32.
R.
Patel
,
D.
Dubrovskiy
, and
M.
Döllinger
, “
Characterizing vibratory kinematics in children and adults with high-speed digital imaging
,”
J. Speech Lang. Hear. Res.
57
,
674
686
(
2014
).
33.
R.
Patel
,
D.
Dubrovskiy
, and
M.
Döllinger
, “
Measurement of glottal cycle characteristics between children and adults: Physiological variations
,”
J. Voice
28
,
476
486
(
2014
).
34.
R. J.
Baken
and
R. F.
Orlikoff
, “
Laryngeal function
,” in
Clinical Measurement of Speech and Voice
, 2nd ed. (
Cengage Learning
,
Clifton Park, NY
,
1999
), Chap.
10
, pp.
407
413
.
35.
Q.
Qiu
,
H. K.
Schutte
,
L.
Gu
, and
Q.
Yu
, “
An automatic method to quantify the vibration properties of human vocal folds via videokymography
,”
Folia Phoniatr. Logo.
55
,
128
136
(
2003
).
36.
J.
Kreiman
and
B. R.
Gerratt
, “
Perceptual sensitivity to first harmonic amplitude in the voice source
,”
J. Acoust. Soc. Am.
128
,
2085
2089
(
2010
).
37.
J.
Hillenbrand
and
R. A.
Houde
, “
Acoustic correlates of breathy vocal quality: Dysphonic voices and continuous speech
,”
J. Speech Hear. Res.
39
,
311
321
(
1996
).
38.
R. A.
Samlan
and
B. H.
Story
, “
Influence of left-right asymmetries on voice quality in simulated paramedian vocal fold paralysis
,”
J. Speech Lang. Hear. Res.
60
,
306
321
(
2017
).
39.
J.
Hillenbrand
,
R. A.
Cleveland
, and
R. L.
Erickson
, “
Acoustic correlates of breathy vocal quality
,”
J. Speech Hear. Res.
37
,
769
778
(
1994
).
40.
D. K.
Chhetri
,
J.
Neubauer
,
E.
Sofer
, and
D. A.
Berry
, “
Influence and interactions of laryngeal adductors and cricothyroid muscles on fundamental frequency and glottal posture control
,”
J. Acoust. Soc. Am.
135
,
2052
2064
(
2014
).
41.
I.
Titze
, “
On the relation between subglottal pressure and fundamental frequency in phonation
,”
J. Acoust. Soc. Am.
85
,
901
906
(
1989
).
42.
I.
Titze
,
T.
Riede
, and
T.
Mau
, “
Predicting achievable fundamental frequency ranges in vocalization across species
,”
PLoS Comput. Biol.
12
,
e1004907
(
2016
).
43.
A.
Yamauchi
,
H.
Yokonishi
,
H.
Imagawa
,
K.
Sakakibara
,
T.
Nito
, and
N.
Tayama
, “
Quantitative analysis of vocal fold vibration in vocal fold paralysis with the use of high-speed digital imaging
,”
J. Voice.
30
,
766.e13
766.e22
(
2016
).
44.
V.
Wolfe
,
J.
Fitch
, and
R.
Cornell
, “
Acoustic prediction of severity in commonly occurring voice problems
,”
J. Speech Hear. Res.
38
,
273
279
(
1994
).
45.
M.
Kunduk
,
M.
Döllinger
,
A. J.
McWorther
, and
J.
Lohscheller
, “
Assessment of the variability of vocal fold dynamics within and between recordings with high-speed imaging and by phonovibrogram
,”
Laryngoscope
120
,
981
987
(
2010
).
46.
A.
Yamauchi
,
H.
Yokonishi
,
H.
Imagawa
,
K.
Sakakibara
,
T.
Nito
,
N.
Tayama
, and
T.
Yamasoba
, “
Quantitative analysis of digital videokymography: A preliminary study on age- and gender-related difference of vocal fold vibration in normal speakers
,”
J. Voice
29
,
109
119
(
2015
).
47.
M.
Tsutsumi
,
S.
Isotani
,
R. A.
Pimenta
,
M. E.
Dajer
,
A.
Hachjya
,
D. H.
Tsuji
,
N.
Tayama
,
H.
Yokonishi
,
H.
Imagawa
,
A.
Yamauchi
,
S.
Takano
,
K.
Sakakibara
, and
A. N.
Montagnoli
, “
High-speed videolaryngoscopy: Quantitative parameters of glottal area waveforms and high-speed kymography in healthy individuals
,”
J. Voice
31
,
282
290
(
2017
).
48.
H. S.
Bonilha
,
D. D.
Deliyski
, and
T. T.
Gerlach
, “
Phase asymmetries in normophonic speakers: Visual judgments and objective findings
,”
Am. J. Speech. Lang. Pathol.
17
,
367
376
(
2008
).
49.
A.
Yamauchi
,
H.
Yokonishi
,
H.
Imagawa
,
K.
Sakakibara
,
T.
Nito
,
N.
Tayama
, and
T.
Yamasoba
, “
Quantification of vocal fold vibration in various laryngeal disorders using high-speed digital imaging
,”
J. Voice
30
,
205
214
(
2016
).
50.
N.
Isshiki
,
M.
Tanabe
,
K.
Ishizaka
, and
D.
Broad
, “
Clinical significance of asymmetrical vocal cord tension
,”
Ann. Oto. Rhinol. Laran.
86
,
58
66
(
1977
).
51.
J.
Kobayashi
,
E.
Yumoto
,
M.
Hyodo
, and
K.
Gyo
, “
Two-dimensional analysis of vocal fold vibration in unilaterally atrophied larynges
,”
Laryngoscope
110
,
440
446
(
2000
).
52.
M.
Döllinger
,
D. A.
Berry
, and
S.
Kniesburges
, “
Dynamic vocal fold parameters with changing adduction in ex-vivo hemilarynx experiments
,”
J. Acoust. Soc. Am.
139
,
2372
2385
(
2016
).
53.
M.
Zañartu
,
G. E.
Galindo
,
B. D.
Erath
,
S. D.
Peterson
,
G. R.
Wodicka
, and
R. E.
Hillman
, “
Modeling the effects of a posterior glottal opening on vocal fold dynamics with implications for vocal hyperfunction
,”
J. Acoust. Soc. Am.
136
,
3262
3271
(
2014
).
54.
G.
Chen
,
J.
Kreiman
,
Y.
Shue
,
A.
Alwan
, and
D.
Australia
, “
Acoustic correlates of glottal gaps
,” in
2011 Interspeech
,
Florence
,
Italy
, pp.
2673
2676
.
55.
J.
Kreiman
,
Y.
Shue
,
G.
Chen
,
M.
Iseli
,
B. R.
Gerratt
,
J.
Neubauer
, and
A.
Alwan
, “
Variability in the relationships among voice quality, harmonic amplitudes, open quotient, and glottal area waveform shape in sustained phonation
,”
J. Acoust. Soc. Am.
132
,
2625
2632
(
2012
).
56.
A. L.
Rosenthal
,
S. Y.
Lowell
, and
R. H.
Colton
, “
Aerodynamic and acoustic features of vocal effort
,”
J. Voice
28
,
144
153
(
2014
).
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