A hybrid method for estimating temperature with spatial mapping using diagnostic ultrasound, based on detection of echo shifts from tissue undergoing thermal treatment, is proposed. Cross-correlation and zero-crossing tracking are two conventional algorithms used for detecting echo shifts, but their practical applications are limited. The proposed hybrid method combines the advantages of both algorithms with improved accuracy in temperature estimation. In vitro experiments were performed on porcine muscle for preliminary validation and temperature calibration. In addition, thermal mapping of rabbit thigh muscle in vivo during high-intensity focused ultrasound heating was conducted. Results from the in vitro experiments indicated that the difference between the estimated temperature change by the proposed hybrid method and the actual temperature change measured by the thermocouple was generally less than 1 °C when the increase in temperature due to heating was less than 10 °C. For the in vivo study, the area predicted to experience the highest temperature coincided well with the focal point of the high-intensity focused ultrasound transducer. The computational efficiency of the hybrid algorithm was similar to that of the fast cross-correlation algorithm, but with an improved accuracy. The proposed hybrid method could provide an alternative means for non-invasive monitoring of limited temperature changes during hyperthermia therapy.
REFERENCES
1.
J.
Heisterkamp
, R.
van Hillegersberg
, and J. N.
Ijzermans
, “Critical temperature and heating time for coagulation damage: Implications for interstitial laser coagulation (ILC) of tumors
,” Lasers Surg. Med.
25
, 257
–262
(1999
).2.
I.
Hilger
, A.
Rapp
, K. O.
Greulich
, and W. A.
Kaiser
, “Assessment of DNA damage in target tumor cells after thermoablation in mice
,” Radiology
237
, 500
–506
(2005
).3.
J. E.
Kennedy
, G. R.
Ter Haar
, and D.
Cranston
, “High intensity focused ultrasound: Surgery of the future?
,” Br. J. Radiol.
76
, 590
–599
(2003
).4.
C. M. C.
Tempany
, E. A.
Stewart
, N.
McDannold
, B. J.
Quade
, F. A.
Jolesz
, and K.
Hynynen
, “MR imaging-guided focused ultrasound surgery of uterine leiomyomas: A feasibility study
,” Radiology
226
, 897
–905
(2003
).5.
K.
Hynynen
, N. I.
Vykhodtseva
, A. H.
Chung
, V.
Sorrentino
, V.
Colucci
, and F. A.
Jolesz
, “Thermal effects of focused ultrasound on the brain: Determination with MR imaging
,” Radiology
204
, 247
–253
(1997
).6.
A. N.
Amini
, E. S.
Ebbini
, and T. T.
Georgiou
, “Noninvasive estimation of tissue temperature via high-resolution spectral analysis techniques
,” IEEE Trans. Biomed. Eng.
52
, 221
–228
(2005
).7.
N. R.
Miller
, K. M.
Bograchev
, and J. C.
Bamber
, “Ultrasonic temperature imaging for guiding focused ultrasound surgery: Effect of angle between imaging beam and therapy beam
,” Ultrasound Med. Biol.
31
, 401
–413
(2005
).8.
R.
Seip
, “Noninvasive real-time multipoint temperature control for ultrasound phased array treatments
,” IEEE Trans. Ultrasonics Ferroelectr.
43
, 1063
–1073
(1996
).9.
R. M.
Arthur
, W. L.
Straube
, J. D.
Starman
, and E. G.
Moros
, “Noninvasive temperature estimation based on the energy of backscattered ultrasound
,” Med. Phys.
30
, 1021
–1029
(2003
).10.
A.
Anand
and P. J.
Kaczkowski
, “Noninvasive measurement of local thermal diffusivity using backscattered ultrasound and focused ultrasound heating
,” Ultrasound Med. Biol.
34
, 1449
–1464
(2008
).11.
H. L.
Liu
, M. L.
Li
, T. C.
Shih
, S. M.
Huang
, I. Y.
Lu
, D. Y.
Lin
, S. M.
Lin
, and K. C.
Ju
, “Instantaneous frequency-based ultrasonic temperature estimation during focused ultrasound thermal therapy
,” Ultrasound Med. Biol.
35
, 1647
–1661
(2009
).12.
R.
Maass-Moreno
, C. A.
Damianou
, and N. T.
Sanghvi
, “Noninvasive temperature estimation in tissue via ultrasound echo-shifts. Part, I. I. In vitro study
,” J. Acoust. Soc. Am.
100
, 2522
–2530
(1996
).13.
R.
Seip
and E. S.
Ebbini
, “Noninvasive estimation of tissue temperature response to heating fields using diagnostic ultrasound
,” IEEE Trans. Biomed. Eng.
42
, 828
–839
(1995
).14.
C.
Simon
, P.
VanBaren
, and E. S.
Ebbini
, “Two-dimensional temperature estimation using diagnostic ultrasound
,” IEEE Trans. Ultrasonics Ferroelectr.
45
, 1088
–1099
(1998
).15.
A. M.
Pouch
, T. W.
Cary
, S. M.
Schultz
, and C. M.
Sehgal
, “In vivo noninvasive temperature measurement by B-Mode ultrasound imaging
,” J. Ultrasound Med.
29
, 1595
–1606
(2010
).16.
Y.
Lu
, X. Z.
Liu
, X. F.
Gong
, and D.
Zhang
, “Relationship between the temperature and the acoustic nonlinearity parameter in biological tissues
,” Chin. Sci. Bull.
49
, 2360
–2363
(2004
).17.
X.
Liu
, X.
Gong
, C.
Yin
, J.
Li
, and D.
Zhang
, “Noninvasive estimation of temperature elevations in biological tissues using acoustic nonlinearity parameter imaging
,” Ultrasound Med. Biol.
34
, 414
–424
(2008
).18.
B.
Arnal
, M.
Pernot
, and M.
Tanter
, “Monitoring of thermal therapy based on shear modulus changes: II. Shear wave imaging of thermal lesions
,” IEEE Trans. Ultrasonics Ferroelectr.
58
, 1603
–1611
(2011
).19.
B.
Arnal
, M.
Pernot
, and M.
Tanter
, “Monitoring of thermal therapy based on shear modulus changes: I. Shear wave thermometry
,” IEEE Trans. Ultrasonics Ferroelectr.
58
, 369
–378
(2011
).20.
J.
Bercoff
, M.
Tanter
, and M.
Fink
, “Supersonic shear imaging: A new technique for soft tissue elasticity mapping
,” IEEE Trans. Ultrasonics Ferroelectr.
51
, 396
–409
(2004
).21.
C. L.
Yang
, H.
Zhu
, S. C.
Wu
, Y. P.
Bai
, and H. J.
Gao
, “Correlations between B-Mode ultrasonic image texture features and tissue temperature in microwave ablation
,” J. Ultrasound Med.
29
, 1787
–1799
(2010
).22.
T.
Varghese
, J. A.
Zagzebski
, Q.
Chen
, U.
Techavipoo
, G.
Frank
, C.
Johnson
, A.
Wright
, and F. T.
Lee
, Jr., “Ultrasound monitoring of temperature change during radiofrequency ablation: Preliminary in-vivo results
,” Ultrasound Med. Biol.
28
, 321
–329
(2002
).23.
N. R.
Miller
, J. C.
Bamber
, and P. M.
Meaney
, “Fundamental limitations of noninvasive temperature imaging by means of ultrasound echo strain estimation
,” Ultrasound Med. Biol.
28
, 1319
–1333
(2002
).24.
K. C.
Ju
and H. L.
Liu
, “Zero-crossing tracking technique for noninvasive ultrasonic temperature estimation
,” J. Ultrasound Med.
29
, 1607
–1615
(2010
).25.
A. J.
H. Hii
, C. E.
Hann
, J. G.
Chase
, and E. E.
W. Van Houten
, “Fast normalized cross correlation for motion tracking using basis functions
,” Comput. Methods Programs Biomed.
82
, 144
–156
(2006
).26.
J. C.
Yoo
and T. H.
Han
, “Fast normalized cross-correlation
,” Circ. Syst. Signal Process.
28
, 819
–843
(2009
).27.
D. L.
Sandulescu
, D.
Dumitrescu
, I.
Rogoveanu
, and A.
Saftoiu
, “Hybrid ultrasound imaging techniques (fusion imaging)
,” World J. Gastroenterol.
17
, 49
–52
(2011
).28.
R.
Steel
, P. J.
Fish
, K. V.
Ramnarine
, A.
Criton
, H. F.
Routh
, and P. R.
Hoskins
, “Velocity fluctuation reduction in vector Doppler ultrasound using a hybrid single/dual-beam algorithm
,” IEEE Trans. Ultrasonics Ferroelectr. Freq. Control
50
, 89
–93
(2003
).29.
P. J.
Brands
, A. P.
Hoeks
, L. A.
Ledoux
, and R. S.
Reneman
, “A radio frequency domain complex cross-correlation model to estimate blood flow velocity and tissue motion by means of ultrasound
,” Ultrasound Med. Biol.
23
, 911
–920
(1997
).30.
C.
Jahnke
, I.
Paetsch
, K.
Nehrke
, B.
Schnackenburg
, A.
Bornstedt
, R.
Gebker
, E.
Fleck
, and E.
Nagel
, “A new approach for rapid assessment of the cardiac rest period for coronary MRA
,” J. Cardiovasc. Magn. Reson.
7
, 395
–399
(2005
).31.
K.
Nehrke
and P.
Börnert
, “Prospective correction of affine motion for arbitrary MR sequences on a clinical scanner
,” Magn. Reson. Med.
54
, 1130
–1138
(2005
).32.
W. R.
Hedrick
, D. L.
Hykes
, and D. E.
Starchman
, Ultrasound physics and instrumentation
, 3rd ed. (Mosby
, St. Louis
, 1995
).33.
H. L.
Liu
, M. L.
Li
, P. H.
Tsui
, M. S.
Lin
, S. M.
Huang
, and J.
Bai
, “A unified approach to combine temperature estimation and elastography for thermal lesion determination in focused ultrasound thermal therapy
,” Phys. Med. Biol.
56
, 169
–186
(2011
).© 2013 Acoustical Society of America.
2013
Acoustical Society of America
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