A quantitative model is presented that describes the formation of auditory brainstem responses (ABRs) to tone pulses, clicks, and rising chirps as a function of stimulation level. The model computes the convolution of the instantaneous discharge rates using the “humanized” nonlinear auditory-nerve model of Zilany and Bruce [J. Acoust. Soc. Am. 122, 402–417 (2007)] and an empirically derived unitary response function which is assumed to reflect contributions from different cell populations within the auditory brainstem, recorded at a given pair of electrodes on the scalp. It is shown that the model accounts for the decrease of tone-pulse evoked wave-V latency with frequency but underestimates the level dependency of the tone-pulse as well as click-evoked latency values. Furthermore, the model correctly predicts the nonlinear wave-V amplitude behavior in response to the chirp stimulation both as a function of chirp sweeping rate and level. Overall, the results support the hypothesis that the pattern of ABR generation is strongly affected by the nonlinear and dispersive processes in the cochlea.
REFERENCES
1.
Agung
, K.
, Purdy
, S. C.
, McMahon
, C. M.
, and Newall
, P.
(2006
). “The use of cortical auditory evoked potentials to evaluate neural encoding of speech sounds in adults
,” J. Am. Acad. Audiol
17
, 559
–572
.2.
Aiken
, S. J.
, and Picton
, T. W.
(2008
). “Envelope and spectral frequency-following responses to vowel sounds
,” Hear. Res.
245
, 35
–47
.3.
Akhoun
, I.
, Gallego
, S.
, Moulin
, A.
, Menard
, M.
, Veuillet
, E.
, Berger-Vachon
, C.
, Collet
, L.
, and Thai-Van
, H.
(2008
). “The temporal relationship between speech auditory brainstem responses and the acoustic pattern of the phoneme vertical bar ba vertical bar in normal- hearing adults
,” Clin. Neurophysiol.
119
, 922
–933
.4.
Anderson
, S.
, Parbery-Clark
, A.
, Yi
, H.-G.
, and Kraus
, N.
(2011
). “A neural basis of speech-in-noise perception in older adults
,” Ear Hear.
32
, 750
–757
.5.
Bentsen
, T.
, Harte
, J. M.
, and Dau
, T.
(2011
). “Human cochlear tuning estimates from stimulus-frequency otoacoustic emissions
,” J. Acoust. Soc. Am.
129
, 3797
–3807
.6.
Bohorquez
, J.
, and Özdamar
, O.
(2008
). “Generation of the 40-Hz auditory steady-state response (ASSR) explained using convolution
,” Clin. Neurophysiol.
119
, 2598
–2607
.7.
Chandrasekaran
, B.
, and Kraus
, N.
(2010
). “The scalp-recorded brainstem response to speech: Neural origins and plasticity
,” Psychophysiology
47
, 236
–246
.8.
Chertoff
, M.
(2004
). “Analytic treatment of the compound action potential: Estimating the summed post-stimulus time histogram and unit response
,” J. Acoust. Soc. Am.
116
, 3022
–3030
.9.
Chertoff
, M.
, Lichtenhan
, J.
, and Willis
, M.
(2010
). “Click- and chirp-evoked human compound action potentials
,” J. Acoust. Soc. Am.
127
, 2992
–2996
.10.
Dau
, T.
(2003
). “The importance of cochlear processing for the formation of auditory brain-stem and frequency following responses
,” J. Acoust. Soc. Am.
113
, 936
–950
.11.
Dau
, T.
, Wegner
, O.
, Mellert
, V.
, and Kollmeier
, B.
(2000
). “Auditory brainstem responses with optimized chirp signals compensating basilar membrane dispersion
,” J. Acoust. Soc. Am.
107
, 1530
–1540
.12.
deBoer
, E.
(1975
). “Synthetic whole-nerve action potentials for the cat
,” J. Acoust. Soc. Am.
58
, 1030
–1045
.13.
Delgutte
, B.
(1990
). “Physiological-mechanics og psychophysical masking—observations from auditory-nerve fibers
,” J. Acoust. Soc. Am.
87
, 791
–809
.14.
Don
, M.
, and Eggermont
, J.
(1978
). “Analysis of click-evoked brain-stem potentials in man using high-pass noise masking
,” J. Acoust. Soc. Am.
63
, 1084
–1092
.16.
Eggermont
, J.
, and Don
, M.
(1980
). “Analysis of the click-evoked brain-stem potentials in humans using high-pass noise masking. II. Effect of click intensity
,” J. Acoust. Soc. Am.
68
, 1671
–1675
.17.
Elberling
, C.
(1976
). “High frequency evoked action potentials recorded from the ear canal in man
,” Scand. Audiol.
5
, 157
–164
.18.
Elberling
, C.
, Callø
, J.
, and Don
, M.
(2010
). “Evaluating auditory brainstem responses to different chirp stimuli at three levels of stimulation
,” J. Acoust. Soc. Am.
128
, 215
–223
.19.
Elberling
, C.
, and Don
, M.
(2008
). “Auditory brainstem responses to a chirp stimulus designed from derived-band latencies in normal-hearing subjects
,” J. Acoust. Soc. Am.
124
, 3022
–3037
.20.
Elberling
, C.
, and Don
, M.
(2010
). “A direct approach for the design of chirp stimuli used for the recording of auditory brainstem responses
,” J. Acoust. Soc. Am.
128
, 2955
–2964
.21.
Elberling
, C.
, Kristensen
, S. G. B.
, and Don
, M.
(2012
). “Auditory brainstem responses to chirps delivered by different insert earphones
,” J. Acoust. Soc. Am.
131
, 2091
–2100
.22.
Fobel
, O.
, and Dau
, T.
(2004
). “Searching for the optimal stimulus eliciting auditory brain-stem responses in humans
,” J. Acoust. Soc. Am.
116
, 2213
–2222
.23.
Folsom
, R.
(1984
). “Frequency specificity of human auditory brain-stem responses as revealed by pure-tone masking profiles
,” J. Acoust. Soc. Am.
75
, 919
–924
.24.
Galambos
, R.
, Makeig
, S.
, and Talmachoff
, P.
(1981
). “A 40 Hz auditory potential recorded from the human scalp
,” Proc. Natl. Acad. Sci. U.S.A.
78
, 2643
–2647
.25.
Glasberg
, B. R.
, and Moore
, B. C.
(1990
). “Derivation of auditory filter shapes from notched-noise data
,” Hear. Res.
47
, 103
–138
.26.
Goldstein
, M.
, and Kiang
, N.
(1958
). “Synchrony of neural activity in electric responses evoked by transient acoustic stimuli
,” J. Acoust. Soc. Am.
30
, 107
–114
.27.
Gorga
, M.
, Kaminski
, J.
, Beauchine
, K.
, and Jesteadt
, W.
(1988
). “Auditory brain-stem responses to tone bursts in normally hearing subjects
,” J. Speech Hear. Res.
31
, 87
–97
.28.
Greenwood
, D.
(1990
). “A cochlear frequency-position function for several species—19 years later
,” J. Acoust. Soc. Am.
87
, 2592
–2605
.29.
Hansen
, P. C. H.
(1998
). “Regularization tools. A matlab package for analysis and solution of discrete ill-posed problems
,” http://www2.imm.dtu.dk/∼pch/ (date last viewed 10/26/11).30.
Harte
, J.
, Pigasse
, G.
, and Dau
, T.
(2009
). “Comparison of cochlear delay estimates using otoacoustic emissions and auditory brainstem responses
,” J. Acoust. Soc. Am.
126
, 1291
–1301
.31.
Harte
, J.
, Rønne
, F.
, and Dau
, T.
(2010
). “Modeling human auditory evoked brainstem re- sponses based on nonlinear cochlear processing
,” in Proceedings of 20th International Congress on Acoustics
.32.
Heinz
, M.
, Zhang
, X.
, Bruce
, I.
, and Carney
, L.
(2001
). “Auditory nerve model for predicting performance limits of normal and impaired listeners
,” ARLO
5
, 91
–96
.33.
Ibrahim
, R. A.
, and Bruce
, I. C.
(2010
). “Effects of peripheral tuning on the auditory nerve’s representation of speech envelope and temporal fine structure cues
,” in Neurophysiological Bases of Auditory Perception
, edited by E. A.
Lopez-Poveda
and A. R.
Palmer
, 15th International Symposium on Hearing, Salamanca, Spain, 1–5 June, pp. 429
–438
, Med Elect. Hear Life.34.
Jewett
, D.
, and Williston
, J.
(1971
). “Auditory-evoked far fields averaged from scalp of humans
,” Brain
94
, 681
–696
.35.
John
, M.
, and Picton
, T.
(2000
). “Human auditory steady-state responses to amplitude- modulated tones: phase and latency measurements
,” Hear. Res.
141
, 57
–79
.37.
Joris
, P. X.
, Bergevin
, C.
, Kalluri
, R.
, McLaughlin
, M.
, Michelet
, P.
, van der Heijden
, M.
, and Shera
, C. A.
(2011
). “Frequency selectivity in Old-World monkeys corroborates sharp cochlear tuning in humans
,” Proc. Natl. Acad. Sci. U.S.A.
108
, 17516
–17520
.36.
Joris
, P. X.
, Carney
, L. H.
, Smith
, P. H.
, and Yin
, T. C. T.
(1994
). “Enhancement of neural synchronization in the anteroventral cochlear nucleus. 1. Responses to tones at the characteristic frequency
,” J. Neurophysiol.
71
, 1022
–1036
.38.
Junius
, D.
, and Dau
, T.
(2005
). “Influence of cochlear traveling wave and neural adaptation on auditory brainstem responses
,” Hear. Res.
205
, 53
–67
.39.
Kiang
, N.
(1965
). Discharge Patterns of Single Fibers in the Cat’s Auditory Nerve
(MIT
, Cambridge, MA
), pp. 32
–67
.40.
Kiang
, N.
(1990
). “Curious oddments of auditory-nerve studies
,” Hear. Res.
49
, 1
–16
.41.
Kuwada
, S.
, Batra
, R.
, and Maher
, V.
(1986
). “Scalp potentials of normal and hearing- impaired subjects in response to sinusoidally amplitude-modulated tones
,” Hear. Res.
21
, 179
–192
.42.
Lalor
, E. C.
, and Foxe
, J. J.
(2010
). “Neural responses to uninterrupted natural speech can be extracted with precise temporal resolution
,” Eur. J. Neurosci.
31
, 189
–193
.43.
Melcher
, J.
, and Kiang
, N.
(1996
). “Generators of the brainstem auditory evoked potential in cat. 3. Identified cell populations
,” Hear. Res.
93
, 52
–71
.44.
Murray
, J.
, Cohn
, E.
, Harker
, L.
, and Gorga
, M.
(1998
). “Tone burst auditory brain stem response latency estimates of cochlear travel time in Meniere’s disease, cochlear hearing loss, and normal ears
,” Am. J. Otol.
19
, 854
–859
.45.
Neely
, S.
, Norton
, S.
, Gorga
, M.
, and, Jesteadt
, W.
(1988
). “Latency of auditory brain-stem responses and otoacoustic emissions using tone-burst stimuli
,” J. Acoust. Soc. Am.
83
, 652
–656
.46.
Pascal
, J.
, Bourgeade
, A.
, Lagier
, M.
, and Legros
, C.
(1998
). “Linear and nonlinear model of the human middle ear
,” J. Acoust. Soc. Am.
104
, 1509
–1516
.47.
Picton
, T.
, Skinner
, C.
, Champagne
, S.
, Kellett
, A.
, and Maiste
, A.
(1987
). “Potentials-evoked by the sinusoidal modulation of the amplitude or frequency of a tone
,” J. Acoust. Soc. Am.
82
, 165
–178
.48.
Puria
, S.
(2003
). “Measurements of human middle ear forward and reverse acoustics: Implications for otoacoustic emissions
,” J. Acoust. Soc. Am.
113
, 2773
–2789
.49.
Recio
, A.
, and Rhode
, W.
(2000
). “Basilar membrane responses to broadband stimuli
,” J. Acoust. Soc. Am.
108
, 2281
–2298
.50.
Rees
, A.
, Green
, G.
, and Kay
, R.
(1986
). “Steady-state evoked-responses to sinusoidally amplitude-modulated sounds recorded in man
,” Hear. Res.
23
, 123
–133
.51.
Rhode
, W.
, and Recio
, A.
(2000
). “Study of mechanical motions in the basal region of the chinchilla cochlea
,” J. Acoust. Soc. Am.
107
, 3317
–3332
.52.
Ribeiro
, F. M.
, and Carvallo
, R. M.
(2008
). “Tone-evoked ABR in full-term and preterm neonates with normal hearing
,” Int. J. Audiol.
47
, 21
–29
.53.
Richter
, U.
, and Fedtke
, T.
(2005
). “Reference zero for the calibration of audiometric equip- ment using ‘clicks’ as test signals
,” Int. J. Audiol.
44
, 478
–487
.54.
Rønne
, F. M.
, Harte
, J.
, Elberling
, C.
, and Dau
, T.
(2011
). “Modeling the level-dependent latency of the auditory brainstem response
,” in Proceedings of Forum Acousticum
.55.
Ruggero
, M.
, Rich
, N.
, Recio
, A.
, Narayan
, S.
, and Robles
, L.
(1997
). “Basilar-membrane responses to tones at the base of the chinchilla cochlea
,” J. Acoust. Soc. Am.
101
, 2151
–2163
.56.
Serpanos
, Y. C.
, O’Malley
, H.
, and Gravel
, J. S.
(1997
). “The relationship between loudness intensity functions and the click-ABR wave V latency
,” Ear Hear.
101
, 2151
–2163
.57.
Shera
, C.
, Guinan
, J.
, and Oxenham
, A.
(2002
). “Revised estimates of human cochlear tun- ing from otoacoustic and behavioral measurements
,” Proc. Natl. Acad. Sci. U.S.A.
99
, 3318
–3323
.58.
Shera
, C. A.
, Guinan
, J. J.
, Jr., and Oxenham
, A. J.
(2010
). “Otoacoustic estimation of cochlear tuning: Validation in the chinchilla
,” J. Assoc. Res. Otolaryngol.
11
, 343
–365
.59.
Shore
, S.
, and Nuttall
, A.
(1985
). “High-synchrony cochlear compound action-potentials evoked by rising frequency-swept tone bursts
,” J. Acoust. Soc. Am.
78
, 1286
–1295
.60.
Søndergaard
, P.
, Culling
, J. F.
, Dau
, T.
, Le Goff
, N.
, Jepsen
, M. L.
, Majdak
, P.
, and Wierstorf
, H.
(2011
). “Towards a binaural modelling toolbox
,” in Proceedings of the Forum Acousticum
.61.
Swaminathan
, J.
, Krishnan
, A.
, and Gandour
, J. T.
(2008
). “Pitch encoding in speech and nonspeech contexts in the human auditory brainstem
,” NeuroReport
19
, 1163
–1167
.62.
Tikhonov
, A.
(1963
). “Solution of incorrectly formulated problems and regularization method
,” Dokl. Akad. Nauk SSSR
151
, 1035
–1038
.63.
Warrier
, C.
, Johnson
, K.
, Hayes
, E.
, Nicol
, T.
, and Kraus
, N.
(2004
). “Learning impaired children exhibit timing deficits and training-related improvements in auditory cortical re- sponses to speech in noise
,” Exp. Brain Res.
157
, 431
–441
.64.
Westerman
, L.
, and Smith
, R.
(1988
). “A diffusion-model of the transient-response of the cochlear inner hair cell synapse
,” J. Acoust. Soc. Am.
83
, 2266
–2276
.65.
Zilany
, M. S. A.
, and Bruce
, I. C.
(2006
). “Modeling auditory-nerve responses for high sound pressure levels in the normal and impaired auditory periphery
,” J. Acoust. Soc. Am.
120
, 1446
–1466
.66.
Zilany
, M. S. A.
, and Bruce
, I. C.
(2007
). “Representation of the vowel (epsilon) in normal and impaired auditory nerve fibers: Model predictions of responses in cats
,” J. Acoust. Soc. Am.
122
, 402
–417
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