A detailed understanding of the response of single microbubbles subjected to ultrasound is fundamental to a full understanding of the contrast-enhancing abilities of microbubbles in medical ultrasound imaging, in targeted molecular imaging with ultrasound, and in ultrasound-mediated drug delivery with microbubbles. Here, single microbubbles are isolated and their ultrasound-induced radial dynamics recorded with an ultra-high-speed camera at up to 25 million frames per second. The sound emission is recorded simultaneously with a calibrated single element transducer. It is shown that the sound emission can be predicted directly from the optically recorded radial dynamics, and vice versa, that the nanometer-scale radial dynamics can be predicted from the acoustic response recorded in the far field.
Combined optical and acoustical detection of single microbubble dynamics
Jeroen Sijl, Hendrik J. Vos, Timo Rozendal, Nico de Jong, Detlef Lohse, Michel Versluis; Combined optical and acoustical detection of single microbubble dynamics. J. Acoust. Soc. Am. 1 November 2011; 130 (5): 3271–3281. https://doi.org/10.1121/1.3626155
Download citation file: