Absolute backscatter coefficients in tissue-mimicking phantoms were experimentally determined in the 5–50 MHz frequency range using a broadband technique. A focused broadband transducer from a commercial research system, the VisualSonics Vevo 770, was used with two tissue-mimicking phantoms. The phantoms differed regarding the thin layers covering their surfaces to prevent desiccation and regarding glass bead concentrations and diameter distributions. Ultrasound scanning of these phantoms was performed through the thin layer. To avoid signal saturation, the power spectra obtained from the backscattered radio frequency signals were calibrated by using the signal from a liquid planar reflector, a water-brominated hydrocarbon interface with acoustic impedance close to that of water. Experimental values of absolute backscatter coefficients were compared with those predicted by the Faran scattering model over the frequency range 5–50 MHz. The mean percent difference and standard deviation was 54% ± 45% for the phantom with a mean glass bead diameter of 5.40 μm and was 47% ± 28% for the phantom with 5.16 μm mean diameter beads.

1.
E. L.
Madsen
,
F.
Dong
,
G. R.
Frank
,
B. S.
Garra
,
K. A.
Wear
,
T.
Wilson
,
J. A.
Zagzebski
,
H. L.
Miller
,
K. K.
Shung
,
S. H.
Wang
,
E. J.
Feleppa
,
T.
Liu
,
W. D.
O’Brien
,
K. A.
Topp
,
N. T.
Sanghvi
,
A. V.
Zaitsev
,
T. J.
Hall
,
J. B.
Fowlkes
,
O. D.
Kripfgans
, and
J. G.
Miller
, “
Interlaboratory comparison of ultrasonic backscatter, attenuation, and speed measurements
,”
J. Ultrasound. Med.
18
,
615
631
(
1999
).
2.
K. A.
Wear
,
T. A.
Stiles
,
G. R.
Frank
,
E. L.
Madsen
,
F.
Cheng
,
E. J.
Feleppa
,
C. S.
Hall
,
B. S.
Kim
,
P.
Lee
,
W. D.
O’Brien
,
M. L.
Oelze
,
B. I.
Raju
,
K. K.
Shung
,
T. A.
Wilson
, and
J. R.
Yuan
, “
Interlaboratory comparison of ultrasonic backscatter coefficient measurements from 2 to 9 MHz
,”
J. Ultrasound. Med.
24
,
1235
1250
(
2005
).
3.
M. O.
Culjat
,
D.
Goldenberg
,
P.
Tewari
, and
R. S.
Singh
, “
A review of tissue substitutes for ultrasound imaging
,”
Ultrasound Med. Biol.
36
,
861
873
(
2010
).
4.
C. M.
Moran
,
W.
Ellis
,
S. D.
Pye
, and
S.
Smart
, “
Characterizing the performance of a high resolution ultrasound scanner for pre-clinical ultrasound imaging
,”
Proc.–IEEE Ultrason. Symp.
2
,
1724
1727
(
2008
).
5.
B.
Raju
, and
M.
Srinivasan
, “
High-frequency ultrasonic attenuation and backscatter coefficients of in vivo normal human dermis and subcutaneous fat
,”
Ultrasound Med. Biol.
27
,
1543
1556
(
2010
).
6.
L. X.
Yao
,
J. A.
Zagzebski
, and
E. L.
Madsen
, “
Backscatter coefficient measurements using a reference phantom to extract depth-dependent instrumentation factors
,”
Ultrason. Imag.
12
,
58
70
(
1990
).
7.
M. P.
Brewin
,
L. C.
Pike
,
D. E.
Rowland
, and
M. J.
Birch
, “
The acoustic properties, centered on 20 MHz, of an IEC agar-based tissue-mimicking material and its temperature, frequency and age dependence
,”
Ultrasound Med. Biol.
34
,
1292
1306
(
2008
).
8.
J. J.
Faran
, “
Sound scattering by solid cylinders and spheres
,”
J. Acoust. Soc. Am.
23
,
405
418
(
1951
).
9.
E. L.
Madsen
,
M. F.
Insana
, and
J. A.
Zagzebski
, “
Method of data reduction for accurate determination of acoustic backscatter coefficients
,”
J. Acoust. Soc. Am.
76
,
913
923
(
1984
).
10.
J. F.
Chen
,
J. A.
Zagzebski
, and
E. L.
Madsen
, “
Tests of backscatter coefficient measurement using broadband pulses
,”
IEEE Trans. Ultrason. Ferroelectr. Freq. Control
40
,
603
7
(
1993
).
11.
E.
Madsen
,
G.
Frank
,
M.
McCormick
, and
M.
Deaner
, “
Anechoic sphere phantom for estimating 3-D resolution of very high frequency ultrasound scanners
,”
IEEE Trans. Ultrason. Ferroelectr. Freq. Control
57
,
2284
2292
(
2010
).
12.
M.
Rosenblatt
, “
Remarks on some nonparametric estimates of a density function
,”
Ann. Math. Stat.
27
,
832
837
(
1956
).
13.
E.
Parzen
, “
On estimation of a probability density function and mode
,”
Ann. Math. Stat.
33
,
1065
1076
(
1962
).
14.
B. W.
Silverman
,
Monographs on Statistics and Applied Probability: Density Estimation for Statistics and Data Analysis
(
Chapman and Hall/CRC
,
London
,
1986
).
15.
M.
Laurel
, and American Institute of Ultrasound in Medicine Technical Standards Committee,
Methods for Specifying Acoustic Properties of Tissue Mimicking Phantoms and Objects. Stage 1
(
American Institute of Ultrasound in Medicine
,
1995
).
16.
K. A.
Wear
, “
Group velocity, phase velocity, and dispersion in human calcaneus in vivo
,”
J. Acoust. Soc. Am.
121
,
2431
2437
(
2007
).
17.
V. A.
Del Grosso
and
C. W.
Mader
, “
Speed of sound in pure water
,”
J. Acoust. Soc. Am.
5
,
1442
1446
(
1972
).
18.
T. J.
Hall
,
E. L.
Madsen
,
F.
Dong
,
I. R.
Medina
, and
G. R.
Frank
, “
Low-reflection-coefficient liquid interfaces for system characterization
,”
Ultrasound Med. Biol.
27
,
1003
1010
(
2001
).
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