Auditory neurobiology has benefited significantly from ethological approaches using acoustic communication signals. Developing an ethological model in a genetically manipulable system such as the mouse would enhance the ability to investigate the processing, learning, and recognition of sounds. Characterizing the basic acoustic structure of mouse vocalizations would help lay a foundation for such a future study. Towards this goal, ultrasound vocalizations emitted by isolated mouse pups and pairs of adult males and females have been digitally recorded and examined. Previous work suggests that these calls may have communicative significance. An analysis of the natural variability in their spectral content, median frequency, duration, and repetition period reveals acoustic structure that could be used for recognizing the calls. Other parameters, like the rate of frequency modulation, may also be informative, but have not been examined. Pup isolation calls develop systematically between postnatal day 5 and 12 towards a more stereotyped vocalization—contracting from a wide range of values into narrower clusters of frequency and duration, and shifting from longer to shorter repetition periods. Most significantly, pup isolation and adult encounter calls fall into two distinct spectral and temporal categories, making it possible for a receiver to acoustically distinguish between them, and to potentially categorically perceive them along those dimensions.
REFERENCES
1.
Alford
, B. R.
, and Ruben
, R. J.
(1963
). “Physiological, behavioral and anatomical correlates of the development of hearing in the mouse
,” Ann. Otol. Rhinol. Laryngol.
72
, 237
–247
.2.
Beck
, J. A.
, Lloyd
, S.
, Hafezparast
, M.
, Lennon-Pierce
, M.
, Eppig
, J. T.
, Festing
, M. F.
, and Fisher
, E. M.
(2000
). “Genealogies of mouse inbred strains
,” Nat. Genet.
24
(1
), 5
, 23
.3.
Beeman, K. (1998). “Digital signal analysis, editing and synthesis,” in Animal Acoustic Communication, edited by S. L. Hopp, M. J. Owren, and C. S. Evans (Springer-Verlag, New York), pp. 59–103.
4.
Bell
, R. W.
, Nitschke
, W.
, and Zachman
, T. A.
(1972
). “Ultra-sounds in three inbred strains of young mice
,” Behav. Biol.
7
(6
), 805
–814
.5.
Blumberg
, M. S.
, Sokoloff
, G.
, and Kent
, K. J.
(2000
). “A developmental analysis of clonidine’s effects on cardiac rate and ultrasound production in infant rats
,” Dev. Psychobiol.
36
(3
), 186
–193
.6.
Boll
, S. F.
(1979
). “Suppression of acoustic noise in speech using spectral subtraction
,” IEEE Trans. Acoust., Speech, Signal Process.
ASSP-27
(2
), 113
–120
.7.
Branchi
, I.
, Santucci
, D.
, Vitale
, A.
, and Alleva
, E.
(1998
). “Ultrasonic vocalizations by infant laboratory mice: a preliminary spectrographic characterization under different conditions
,” Dev. Psychobiol.
33
(3
), 249
–256
.8.
Brand
, A.
, Urban
, R.
, and Grothe
, B.
(2000
). “Duration tuning in the mouse auditory midbrain
,” J. Neurophysiol.
84
(4
), 1790
–1799
.9.
Brown
, A. M.
(1973
). “High frequency peaks in the cochlear microphonic response of rodents
,” J. Comp. Physiol.
83
, 377
–392
.10.
D’Amato
, F. R.
, and Moles
, A.
(2001
). “Ultrasonic vocalizations as an index of social memory in female mice
,” Behav. Neurosci.
115
(4
), 834
–840
.11.
Efron, B., and Tibshirani, R. J. (1993). An Introduction to the Bootstrap (Chapman and Hall, New York).
12.
Egorova
, M. A.
, Vartanyan
, I. A.
, and Ehret
, G.
(2002
). “Neural critical bands and inhibition in the auditory midbrain of the house mouse (mus domesticus)
,” Dokl. Biol. Sci.
382
, 5
–7
.13.
Ehret
, G.
(1975
). “Masked auditory thresholds, critical ratios, and scales of the basilar membrane of the housemouse (mus musculus)
,” J. Comp. Physiol.
103
, 329
–341
.14.
Ehret
, G.
(1976
). “Development of absolute auditory thresholds in the house mouse (mus musculus)
,” J. Am. Audiol Soc.
1
(5
), 179
–184
.15.
Ehret, G. (1983). “Auditory processing and perception of ultrasounds in house mice,” in Advances in Vertebrate Neuroethology, edited by J-P. Ewert, R. R. Capranica, and D. J. Ingle, NATO advanced science institutes series. Series A, Life Sciences (Plenum, New York), 56th ed.
16.
Ehret
, G.
(1992
). “Categorical perception of mouse-pup ultrasounds in the temporal domain
,” Anim. Behav.
43
(3
), 409
–416
.17.
Ehret
, G.
, and Haack
, B.
(1981
). “Categorical perception of mouse pup ultrasound by lactating females
,” Naturwissenschaften
68
(4
), 208
–209
.18.
Ehret
, G.
, and Haack
, B.
(1982
). “Ultrasound recognition in house mice: key-stimulus configuration and recognition mechanism
,” J. Comp. Physiol., A
148
(2
), 245
–251
.19.
Elwood
, R. W.
, and Keeling
, F.
(1982
). “Temporal organization of ultrasonic vocalizations in infant mice
,” Dev. Psychobiol.
15
(3
), 221
–227
.20.
Green, D. M., and Swets, J. A. (1988). Signal Detection Theory and Psychophysics (Penninsula, Los Altos, CA).
21.
Haack, B., Markl, H., and Ehret, G. (1983). “Sound communication between parents and offspring,” in The Auditory Psychobiology of the Mouse, edited by J. F. Willott (Thomas, Springfield, IL), pp. 57–97.
22.
Hahn
, M. E.
, Hewitt
, J. K.
, Adams
, M.
, and Tully
, T.
(1987
). “Genetic influences on ultrasonic vocalizations in young mice
,” Behav. Genet.
17
(2
), 155
–166
.23.
Hahn
, M. E.
, Karkowski
, L.
, Weinreb
, L.
, Henry
, A.
, Schanz
, N.
, and Hahn
, E. M.
(1998
). “Genetic and developmental influences on infant mouse ultrasonic calling. II. Developmental patterns in the calls of mice 2-12 days of age
,” Behav. Genet.
28
(4
), 315
–325
.24.
Harnad, S. R. (1987). Categorical Perception: The Groundwork of Cognition (Cambridge U.P., New York).
25.
Hauser, M. D. (1996). The Evolution of Communication (MIT, Cambridge, MA).
26.
Hurst
, J. L.
, Payne
, C. E.
, Nevison
, C. M.
, Marie
, A. D.
, Humphries
, R. E.
, Robertson
, D. H.
, Cavaggioni
, A.
, and Beynon
, R. J.
(2001
). “Individual recognition in mice mediated by major urinary proteins
,” Nature (London)
414
(6864
), 631
–634
.27.
Lewicki
, M. S.
(2002
). “Efficient coding of natural sounds
,” Nat. Neurosci.
5
(4
), 356
–363
.28.
Mikaelian
, D.
, and Ruben
, R. J.
(1964
). “Development of hearing in the normal CBA-J mouse
,” Acta Oto-Laryngol.
59
, 451
–461
.29.
Moore, B. C. J. (1997). An Introduction to the Psychology of Hearing, 4th ed. (Academic, San Diego).
30.
Motomura
, N.
, Shimizu
, K.
, Shimizu
, M.
, Aoki-Komori
, S.
, Taniguchi
, K.
, Serizawa
, I.
, and Saito
, T. R.
(2002
). “A comparative study of isolation-induced ultrasonic vocalization in rodent pups
,” Exp. Anim.
51
(2
), 187
–190
.31.
Noirot
, E.
, and Pye
, D.
(1969
). “Sound analysis of ultrasonic distress calls of mouse pups as a function of their age
,” Anim. Behav.
17
, 340
–349
.32.
Nunez
, A. A.
, Pomerantz
, S. M.
, Bean
, N. J.
, and Youngstrom
, T. G.
(1985
). “Effects of laryngeal denervation on ultrasound production and male sexual behavior in rodents
,” Physiol. Behav.
34
(6
), 901
–905
.33.
Nyby, J. G. (2001). “Auditory communication among adults,” in Handbook of Mouse Auditory Research: From Behavior to Molecular Biology, edited by J. F. Willott (CRC, New York), pp. 3–18.
34.
Okon
, E. E.
(1970
). “The effect of environmental temperature on the production of ultrasound by isolated, non-handled, albino mouse pups
,” J. Zool., London
162
, 71
–83
.35.
Ostermeyer
, M. C.
, and Elwood
, R. W.
(1983
). “Pup recognition in mus musculus: parental discrimination between their own and alien young
,” Dev. Psychobiol.
16
(2
), 75
–82
.36.
Pomerantz
, S. M.
, Nunez
, A. A.
, and Bean
, N. J.
(1983
). “Female behavior is affected by male ultrasonic vocalizations in house mice
,” Physiol. Behav.
31
(1
), 91
–96
.37.
Ralls
, K.
(1967
). “Auditory sensitivity in mice, peromyscus and mus musculus
,” Anim. Behav.
15
(1
), 123
–128
.38.
Roberts
, L. H.
(1975
). “The rodent ultrasound production mechanism
,” Ultrasonics
13
(2
), 83
–88
.39.
Roubertoux
, P. L.
, Martin
, B.
, Le Roy
, I.
, Beau
, J.
, Marchaland
, C.
, Perez-Diaz
, F.
, Cohen-Salmon
, C.
, and Carlier
, M.
(1996
). “Vocalizations in newborn mice: genetic analysis
,” Behav. Genet.
26
(4
), 427
–437
.40.
Sales
, G. D.
, and Smith
, J. C.
(1978
). “Comparative studies of the ultrasonic calls of infant murid rodents
,” Dev. Psychobiol.
11
(6
), 595
–619
.41.
Sewell
, G. D.
(1970
). “Ultrasonic communication in rodents
,” Nature (London)
227
(256
), 410
.42.
Shnerson, A., and Pujol, R. (1983). “Development: anatomy, electrophysiology and behavior,” in The Auditory Psychobiology of the Mouse, edited by J. F. Willott (Thomas, Springfield, IL), pp. 395–425.
43.
Smith
, J. C.
(1976
). “Responses of adult mice to models of infant calls
,” J. Comp. Physiol. Psychol.
90
(12
), 1105
–1115
.44.
Smith, J. C., and Sales, G. D. (1980). “Ultrasonic behavior and mother-infant interactions in rodents,” in Maternal Influences and Early Behavior, edited by R. W. Bell and W. P. Smotherman (SP Medical and Scientific Books, New York), pp. 105–133.
45.
Vartanyan
, I. A.
, Egorova
, M. A.
, and Ehret
, G.
(2000
). “Critical bandwidths of different types of neurons in the mouse auditory midbrain
,” Dokl. Biol. Sci.
373
(1-6
), 364
–366
.46.
Warburton
, V. L.
, Sales
, G. D.
, and Milligan
, S. R.
(1989
). “The emission and elicitation of mouse ultrasonic vocalizations: the effects of age, sex and gonadal status
,” Physiol. Behav.
45
(1
), 41
–47
.47.
Whitney
, G.
, Coble
, J. R.
, Stockton
, M. D.
, and Tilson
, E. F.
(1973
). “Ultrasonic emissions: do they facilitate courtship of mice
,” J. Comp. Physiol. Psychol.
84
(3
), 445
–452
.48.
Willott, J. F. (editor) (2001). Handbook of Mouse Auditory Research: From Behavior to Molecular Biology (CRC, New York).
49.
Zheng
, Q. Y.
, Johnson
, K. R.
, and Erway
, L. C.
(1999
). “Assessment of hearing in 80 inbred strains of mice by ABR threshold analyses
,” Hear. Res.
130
(1-2
), 94
–107
.
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