We describe a technique for broadband measurements of the attenuation coefficient and phase velocity of highly attenuating liquid suspensions. To validate the technique we apply it to the ultrasound contrast agent Albunex® at concentrations ranging from particles/mL to particles/mL. These longitudinal wave measurements were performed on Albunex suspensions maintained at in a special time-domain reflectometer designed and constructed in our laboratory. The frequency-dependent attenuation coefficients and phase velocities obtained in the reflectometer are compared to broadband through-transmission measurements of these same quantities, which were also performed in our laboratory. Although comparison data between the two techniques are only available at lower concentrations, the agreement is quite good and serves to validate the methods described in this paper.
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August 2000
August 01 2000
Broadband time-domain reflectometry measurement of attenuation and phase velocity in highly attenuating suspensions with application to the ultrasound contrast medium Albunex® Available to Purchase
Michael S. Hughes;
Michael S. Hughes
Mallinckrodt Inc., St. Louis, Missouri 63042
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Alexander L. Klibanov;
Alexander L. Klibanov
Mallinckrodt Inc., St. Louis, Missouri 63042
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Jon N. Marsh;
Jon N. Marsh
Washington University School of Medicine, St. Louis, Missouri 63110
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James G. Miller;
James G. Miller
Department of Physics, Washington University in St. Louis, Missouri 63130
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Gary H. Brandenburger
Gary H. Brandenburger
Mallinckrodt Inc., St. Louis, Missouri 63042
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Michael S. Hughes
Mallinckrodt Inc., St. Louis, Missouri 63042
Alexander L. Klibanov
Mallinckrodt Inc., St. Louis, Missouri 63042
Jon N. Marsh
Washington University School of Medicine, St. Louis, Missouri 63110
James G. Miller
Department of Physics, Washington University in St. Louis, Missouri 63130
Gary H. Brandenburger
Mallinckrodt Inc., St. Louis, Missouri 63042
J. Acoust. Soc. Am. 108, 813–820 (2000)
Article history
Received:
September 10 1999
Accepted:
April 12 2000
Citation
Michael S. Hughes, Alexander L. Klibanov, Jon N. Marsh, James G. Miller, Gary H. Brandenburger; Broadband time-domain reflectometry measurement of attenuation and phase velocity in highly attenuating suspensions with application to the ultrasound contrast medium Albunex®. J. Acoust. Soc. Am. 1 August 2000; 108 (2): 813–820. https://doi.org/10.1121/1.429614
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