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Journal Articles

Multimodal mechano-microscopy reveals mechanical phenotypes of breast cancer spheroids in three dimensions

Alireza Mowla, Matt S. Hepburn, Jiayue Li, Danielle Vahala, Sebastian E. Amos, Liisa M. Hirvonen, Rowan W. Sanderson, Philip Wijesinghe, Samuel Maher, Yu Suk Choi, Brendan F. Kennedy
Journal: APL Bioengineering
APL Bioeng. 8, 036113 (2024)
https://doi.org/10.1063/5.0213077
Published: September 2024
View article titled, Multimodal mechano-microscopy reveals mechanical phenotypes of breast cancer spheroids in three dimensions
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Journal Articles

Electrophysiological features of cortical 3D networks are deeply modulated by scaffold properties

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Francesca Callegari, Martina Brofiga, Mariateresa Tedesco, Paolo Massobrio
Journal: APL Bioengineering
APL Bioeng. 8, 036112 (2024)
https://doi.org/10.1063/5.0214745
Published: August 2024
View article titled, Electrophysiological features of cortical 3D networks are deeply modulated by scaffold properties
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Journal Articles

Three-dimensional matrix stiffness modulates mechanosensitive and phenotypic alterations in oral squamous cell carcinoma spheroids

Maulee Sheth, Manju Sharma, Maria Lehn, HasanAl Reza, Takanori Takebe, Vinita Takiar, Trisha Wise-Draper, Leyla Esfandiari
Journal: APL Bioengineering
APL Bioeng. 8, 036106 (2024)
https://doi.org/10.1063/5.0210134
Published: July 2024
View article titled, Three-dimensional matrix stiffness modulates mechanosensitive and phenotypic alterations in oral squamous cell carcinoma spheroids
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Journal Articles

Mutual antagonism between CD44 and integrins in glioblastoma cell traction and migration

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Marcus D. Kelly, Matthew R. Pawlak, Kevin H. Zhan, Ghaidan A. Shamsan, Wendy R. Gordon, David J. Odde
Journal: APL Bioengineering
APL Bioeng. 8, 036102 (2024)
https://doi.org/10.1063/5.0203028
Published: July 2024
View article titled, Mutual antagonism between CD44 and integrins in glioblastoma cell traction and migration
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Journal Articles

Dynamic reporters for probing real-time activation of human fibroblasts from single cells to populations

Samantha E. Cassel, Breanna M. Huntington, Wilfred Chen, Pedro Lei, Stelios T. Andreadis, April M. Kloxin
Journal: APL Bioengineering
APL Bioeng. 8, 026127 (2024)
https://doi.org/10.1063/5.0166152
Published: June 2024
View article titled, Dynamic reporters for probing real-time activation of human fibroblasts from single cells to populations
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Journal Articles

Dissecting TGF-β-induced glioblastoma invasion with engineered hyaluronic acid hydrogels

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Kwasi Yeboa Amofa, Katherine Michelle Patterson, Jessica Ortiz, Sanjay Kumar
Journal: APL Bioengineering
APL Bioeng. 8, 026125 (2024)
https://doi.org/10.1063/5.0203213
Published: June 2024
View article titled, Dissecting TGF-β-induced glioblastoma invasion with engineered hyaluronic acid hydrogels
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Journal Articles

Air–liquid intestinal cell culture allows in situ rheological characterization of intestinal mucus

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Pamela C. Cai, Margaret Braunreuther, Audrey Shih, Andrew J. Spakowitz, Gerald G. Fuller, Sarah C. Heilshorn
Journal: APL Bioengineering
APL Bioeng. 8, 026112 (2024)
https://doi.org/10.1063/5.0187974
Published: May 2024
View article titled, Air–liquid intestinal cell culture allows <em>in situ</em> rheological characterization of intestinal mucus
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Includes: Supplementary data
Journal Articles

Different contractility modes control cell escape from multicellular spheroids and tumor explants

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Eliane Blauth, Steffen Grosser, Frank Sauer, Mario Merkel, Hans Kubitschke, Enrico Warmt, Erik W. Morawetz, Philip Friedrich, Benjamin Wolf, Susanne Briest, Grit Gesine Ruth Hiller, Lars-Christian Horn, Bahriye Aktas, Josef A. Käs
Journal: APL Bioengineering
APL Bioeng. 8, 026110 (2024)
https://doi.org/10.1063/5.0188186
Published: May 2024
View article titled, Different contractility modes control cell escape from multicellular spheroids and tumor explants
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Includes: Supplementary data
Journal Articles

Elastocapillary effects determine early matrix deformation by glioblastoma cell spheroids

Ida Ang, Muhammad Sulaiman Yousafzai, Vikrant Yadav, Kyle Mohler, Jesse Rinehart, Nikolaos Bouklas, Michael Murrell
Journal: APL Bioengineering
APL Bioeng. 8, 026109 (2024)
https://doi.org/10.1063/5.0191765
Published: May 2024
View article titled, Elastocapillary effects determine early matrix deformation by glioblastoma cell spheroids
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Includes: Supplementary data
Journal Articles

GelMA micropattern enhances cardiomyocyte organization, maturation, and contraction via contact guidance

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Bin Zhang, Yichen Luo, Xue Zhou, Lei Gao, Xiaohong Yin, Huayong Yang
Journal: APL Bioengineering
APL Bioeng. 8, 026108 (2024)
https://doi.org/10.1063/5.0182585
Published: May 2024
View article titled, GelMA micropattern enhances cardiomyocyte organization, maturation, and contraction via contact guidance
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Includes: Supplementary data
Journal Articles

Engineering approaches for understanding mechanical memory in cancer metastasis

Jia Wen Nicole Lee, Andrew W. Holle
Journal: APL Bioengineering
APL Bioeng. 8, 021503 (2024)
https://doi.org/10.1063/5.0194539
Published: April 2024
View article titled, Engineering approaches for understanding mechanical memory in cancer metastasis
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Journal Articles

Nondestructive, quantitative viability analysis of 3D tissue cultures using machine learning image segmentation

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Kylie J. Trettner, Jeremy Hsieh, Weikun Xiao, Jerry S. H. Lee, Andrea M. Armani
Journal: APL Bioengineering
APL Bioeng. 8, 016121 (2024)
https://doi.org/10.1063/5.0189222
Published: March 2024
View article titled, Nondestructive, quantitative viability analysis of 3D tissue cultures using machine learning image segmentation
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Includes: Supplementary data
Journal Articles

Engineered tissue geometry and Plakophilin-2 regulate electrophysiology of human iPSC-derived cardiomyocytes

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Daniel W. Simmons, Ganesh Malayath, David R. Schuftan, Jingxuan Guo, Kasoorelope Oguntuyo, Ghiska Ramahdita, Yuwen Sun, Samuel D. Jordan, Mary K. Munsell, Brennan Kandalaft, Missy Pear, Stacey L. Rentschler, Nathaniel Huebsch
Journal: APL Bioengineering
APL Bioeng. 8, 016118 (2024)
https://doi.org/10.1063/5.0160677
Published: March 2024
View article titled, Engineered tissue geometry and Plakophilin-2 regulate electrophysiology of human iPSC-derived cardiomyocytes
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Includes: Supplementary data
Journal Articles

Toward innovative approaches for exploring the mechanically regulated tumor-immune microenvironment

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Maria Kalli, Triantafyllos Stylianopoulos
Journal: APL Bioengineering
APL Bioeng. 8, 011501 (2024)
https://doi.org/10.1063/5.0183302
Published: February 2024
View article titled, Toward innovative approaches for exploring the mechanically regulated tumor-immune microenvironment
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Journal Articles

Addition of Laponite to gelatin methacryloyl bioinks improves the rheological properties and printability to create mechanically tailorable cell culture matrices

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Jordan W. Davern, Luke Hipwood, Laura J. Bray, Christoph Meinert, Travis J. Klein
Journal: APL Bioengineering
APL Bioeng. 8, 016101 (2024)
https://doi.org/10.1063/5.0166206
Published: January 2024
View article titled, Addition of Laponite to gelatin methacryloyl bioinks improves the rheological properties and printability to create mechanically tailorable cell culture matrices
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Includes: Supplementary data
Journal Articles

Investigating the reliability of the evoked response in human iPSCs-derived neuronal networks coupled to micro-electrode arrays

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Giorgia Zanini, Giulia Parodi, Michela Chiappalone, Sergio Martinoia
Journal: APL Bioengineering
APL Bioeng. 7, 046121 (2023)
https://doi.org/10.1063/5.0174227
Published: December 2023
View article titled, Investigating the reliability of the evoked response in human iPSCs-derived neuronal networks coupled to micro-electrode arrays
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Includes: Supplementary data
Journal Articles

SEM2: Introducing mechanics in cell and tissue modeling using coarse-grained homogeneous particle dynamics

Sandipan Chattaraj, Michele Torre, Constanze Kalcher, Alexander Stukowski, Simone Morganti, Alessandro Reali, Francesco Silvio Pasqualini
Journal: APL Bioengineering
APL Bioeng. 7, 046118 (2023)
https://doi.org/10.1063/5.0166829
Published: December 2023
View article titled, SEM<sup>2</sup>: Introducing mechanics in cell and tissue modeling using coarse-grained homogeneous particle dynamics
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Includes: Supplementary data
Journal Articles

FRESH™ 3D bioprinted cardiac tissue, a bioengineered platform for in vitro pharmacology

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Samuel Finkel, Shannon Sweet, Tyler Locke, Sydney Smith, Zhefan Wang, Christopher Sandini, John Imredy, Yufang He, Marc Durante, Armando Lagrutta, Adam Feinberg, Andrew Lee
Journal: APL Bioengineering
APL Bioeng. 7, 046113 (2023)
https://doi.org/10.1063/5.0163363
Published: December 2023
View article titled, FRESH™ 3D bioprinted cardiac tissue, a bioengineered platform for <em>in vitro</em> pharmacology
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Includes: Supplementary data
Journal Articles

PCSK9 activation promotes early atherosclerosis in a vascular microphysiological system

Jounghyun H. Lee, Kevin L. Shores, Jason J. Breithaupt, Caleb S. Lee, Daniella M. Fodera, Jennifer B. Kwon, Adarsh R. Ettyreddy, Kristin M. Myers, Benny J. Evison, Alexandra K. Suchowerska, Charles A. Gersbach, Kam W. Leong, George A. Truskey
Journal: APL Bioengineering
APL Bioeng. 7, 046103 (2023)
https://doi.org/10.1063/5.0167440
Published: October 2023
View article titled, PCSK9 activation promotes early atherosclerosis in a vascular microphysiological system
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Includes: Supplementary data
Journal Articles

A tissue-engineered model of the atherosclerotic plaque cap: Toward understanding the role of microcalcifications in plaque rupture

Imke Jansen, Hanneke Crielaard, Tamar Wissing, Carlijn Bouten, Frank Gijsen, Ali C. Akyildiz, Eric Farrell, Kim van der Heiden
Journal: APL Bioengineering
APL Bioeng. 7, 036120 (2023)
https://doi.org/10.1063/5.0168087
Published: September 2023
View article titled, A tissue-engineered model of the atherosclerotic plaque cap: Toward understanding the role of microcalcifications in plaque rupture
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Includes: Supplementary data