We developed a novel imaging mass spectrometer based on our accumulating technology for projection-type imaging mass spectrometry, the simulation of an accurate ion trajectory, and the theory for ion optics. The newly developed apparatus yields high spatial resolution with a substantially shorter image-acquisition time compared with conventional scanning-type imaging mass spectrometers. In order to maintain a high mass resolution, a multi-turn time-of-flight mass spectrometer is combined with post-extraction differential acceleration methods. Consequently, a mass resolution of m/Δm ∼ 10 000 and a spatial resolution of 1 μm were achieved simultaneously in this study. Application of our newly established apparatus to biological samples accomplished successful imaging mass spectrometry by exhibiting an organ-specific distribution of endogenous ions as well as a localized distribution of exogenously applied ions with an ultra-high spatial resolution image in the size of 18.5 megapixels.
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May 2021
Research Article|
May 17 2021
Development of novel projection-type imaging mass spectrometer
J. Aoki
;
J. Aoki
a)
Project Research Center for Fundamental Sciences, Graduate School of Science, Osaka University
, Toyonaka, Osaka 560-0043, Japan
a)Author to whom correspondence should be addressed: [email protected]
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M. Toyoda
M. Toyoda
Project Research Center for Fundamental Sciences, Graduate School of Science, Osaka University
, Toyonaka, Osaka 560-0043, Japan
Search for other works by this author on:
a)Author to whom correspondence should be addressed: [email protected]
Rev. Sci. Instrum. 92, 053706 (2021)
Article history
Received:
November 13 2020
Accepted:
May 04 2021
Citation
J. Aoki, M. Toyoda; Development of novel projection-type imaging mass spectrometer. Rev. Sci. Instrum. 1 May 2021; 92 (5): 053706. https://doi.org/10.1063/5.0037370
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